Ozonated olive oil is the result of a long series of applications of ozone that date back at least fifteen years in dentistry. Ozone (O₃) is a gas that has the property to oxidize inorganic and organic compounds with immediate reaction and is produced by ultraviolet radiation and lightning.

In medicine, ozone can be applied to tissues as ozonated water, gaseous mixture of ozone and oxygen, ozonated water in oil form such as ozonated olive oil. The following are used for oil ozonation: sunflower oil, peanut oil, olive oil, extra virgin olive oil.

Ozonated oil is used in medicine for chronic wound care and in dentistry as an antibacterial to control oral infectious microorganisms in dental plaque and as a subgingival irrigant.

The results of this study demonstrate that application of ozonated olive oil, the topical form of O₃, can accelerate acute skin wound repair in the guinea pig model by promoting collagen synthesis and fibroblast proliferation at the site of injury and increasing the expression of growth factors such as platelet-derived growth factor, growth factor β, and vascular endothelial growth factor. Taken together, we can infer that the application of ozonated olive oil can be considered as an alternative therapeutic modality to improve skin wound healing (1).

This study showed the antibacterial and anti-biofilm activity against S. Mutans of two formulations with ozonated olive oil: Ialozon Blue and Ialozon Pink The study showed the safety of these mouthwashes for daily use, although further data on their efficacy are needed (2).

Ozonated olive oil studies

References_________________________________________________________________

(1) Kim HS, Noh SU, Han YW, Kim KM, Kang H, Kim HO, Park YM. Therapeutic effects of topical application of ozone on acute cutaneous wound healing. J Korean Med Sci. 2009 Jun;24(3):368-74. doi: 10.3346/jkms.2009.24.3.368. 

(2) Nardi GM, Fais S, Casu C, Mazur M, Di Giorgio R, Grassi R, Grassi FR, Orrù G. Mouthwash Based on Ozonated Olive Oil in Caries Prevention: A Preliminary In-Vitro Study. Int J Environ Res Public Health. 2020 Dec 6;17(23):9106. doi: 10.3390/ijerph17239106.