Compendium of the most significant studies with reference to properties, intake, effects.

Maiullari E, Bianco ER, Cortese MG, Magro P, Guanà R, Vinardi S, Canavese F. Conservative treatment of children constipation with Macrogol 4,000. Minerva Pediatr. 2008 Aug;60(4):407-10.

Viaud-Quentric K, Lefranc-Jullien S, Feraille L, Elena PP. Long-term tolerance of preservative-free eye drops containing macrogol hydroxystearate as an excipient. J Fr Ophtalmol. 2016 Feb;39(2):156-63. doi: 10.1016/j.jfo.2015.09.011.

Gullapalli RP, Mazzitelli CL. Polyethylene glycols in oral and parenteral formulations--A critical review. Int J Pharm. 2015 Dec 30;496(2):219-39. doi: 10.1016/j.ijpharm.2015.11.015.

Ichijima R, Suzuki S, Esaki M, Sugita T, Ogura K, Kusano C, Ikehara H, Gotoda T. Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in patients with chronic constipation. BMC Gastroenterol. 2021 Oct 19;21(1):387. doi: 10.1186/s12876-021-01976-2.

Taylor RR, Guest JF. The cost-effectiveness of macrogol 3350 compared to lactulose in the treatment of adults suffering from chronic constipation in the UK. Aliment Pharmacol Ther. 2010 Jan 15;31(2):302-12. doi: 10.1111/j.1365-2036.2009.04191.x.

Zhang Z, Zhang Y, Song S, Yin L, Sun D, Gu J. Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals. J Sep Sci. 2020 May;43(9-10):1978-1997. doi: 10.1002/jssc.201901340.

Charlton RA, Snowball JM, Bloomfield K, de Vries CS. Colorectal cancer risk reduction following macrogol exposure: a cohort and nested case control study in the UK. PLoS One. 2013 Dec 20;8(12):e83203. doi: 10.1371/journal.pone.0083203.

Wegner A, Banaszkiewicz A, Kierkus J, Landowski P, Korlatowicz-Bilar A, Wiecek S, Kwiecien J, Gawronska A, Dembinski L, Czaja-Bulsa G, Socha P. The effectiveness of Lactobacillus reuteri DSM 17938 as an adjunct to macrogol in the treatment of functional constipation in children. A randomized, double-blind, placebo-controlled, multicentre trial. Clin Res Hepatol Gastroenterol. 2018 Oct;42(5):494-500. doi: 10.1016/j.clinre.2018.03.008.

Guest JF, Candy DC, Clegg JP, Edwards D, Helter MT, Dale AK, Fell J, Cosgrove M, Debelle G. Clinical and economic impact of using macrogol 3350 plus electrolytes in an outpatient setting compared to enemas and suppositories and manual evacuation to treat paediatric faecal impaction based on actual clinical practice in England and Wales. Curr Med Res Opin. 2007 Sep;23(9):2213-25. doi: 10.1185/030079907X210462. Erratum in: Curr Med Res Opin. 2020 Mar;36(3):527.

Zhou T, Zhu L, Xia H, He J, Liu S, He S, Wang L, Zhang J. Micelle carriers based on macrogol 15 hydroxystearate for ocular delivery of terbinafine hydrochloride: In vitro characterization and in vivo permeation. Eur J Pharm Sci. 2017 Nov 15;109:288-296. doi: 10.1016/j.ejps.2017.08.020.

Klimek-Chodacka M, Gieniec M, Baranski R. Multiplex Site-Directed Gene Editing Using Polyethylene Glycol-Mediated Delivery of CRISPR gRNA:Cas9 Ribonucleoprotein (RNP) Complexes to Carrot Protoplasts. Int J Mol Sci. 2021 Oct 4;22(19):10740. doi: 10.3390/ijms221910740.