Compendio degli studi più significativi con riferimento a proprietà, assunzione, effetti.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Amoxicillin and Clavulanic Acid. 2018 Oct 31.

Abstract.  Limited information indicates that adverse reactions in infants are uncommon during the use of amoxicillin-clavulanic acid during nursing, with restlessness, diarrhea and rash occurring occasionally. Amoxicillin-clavulanic acid is acceptable in nursing mothers.

Karolyi M, Pawelka E, Kelani H, Funk GC, Lindner B, Porpaczy C, Publig S, Omid S, Seitz T, Traugott M, Turner M, Zoufaly A, Wenisch C. Management of hospitalized influenza A patients during the season 2018/19 : Comparison of three medical departments and the effect on outcome and antibiotic usage. Wien Klin Wochenschr. 2021 Oct 6. doi: 10.1007/s00508-021-01950-8.

Abstract. Diagnosis and treatment of influenza patients are often provided across several medical specialties. We compared patient outcomes at an infectious diseases, a rheumatology and a pulmonology department. 

Saudagar PS, Survase SA, Singhal RS. Clavulanic acid: a review. Biotechnol Adv. 2008 Jul-Aug;26(4):335-51. doi: 10.1016/j.biotechadv.2008.03.002.

Abstract. The review discusses the biosynthetic pathway, fermentative production, downstream processing and applications of Clavulanic acid.

Ser HL, Law JW, Chaiyakunapruk N, Jacob SA, Palanisamy UD, Chan KG, Goh BH, Lee LH. Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review. Front Microbiol. 2016 Apr 22;7:522. doi: 10.3389/fmicb.2016.00522 

Abstract. Overall, these findings provide vital knowledge and insight that could assist media optimization and fermentation design for clavulanic acid production in S. clavuligerus.

Neu HC, Wilson AP, Grüneberg RN. Amoxycillin/clavulanic acid: a review of its efficacy in over 38,500 patients from 1979 to 1992. J Chemother. 1993 Apr;5(2):67-93. doi: 10.1080/1120009x.1993.11739213.

Abstract. Clinical efficacy rates (cure or improved) with amoxycillin/clavulanic acid were 88% and 92% in comparative and uncontrolled trials, respectively. Gastro-intestinal side effects are the most common adverse event but have been relatively infrequent. Amoxycillin/clavulanic acid should continue to be a useful antibiotic for upper and lower respiratory tract infections, skin structure infections, dental, head and neck infections, and selected urinary tract infections.

Carlier M, Noë M, De Waele JJ, Stove V, Verstraete AG, Lipman J, Roberts JA. Population pharmacokinetics and dosing simulations of amoxicillin/clavulanic acid in critically ill patients. J Antimicrob Chemother. 2013 Nov;68(11):2600-8. doi: 10.1093/jac/dkt240.

Abstract. Although vast pharmacokinetic variability exists for both amoxicillin and clavulanic acid in intensive care unit patients, current dosing regiments are appropriate for most patients, except those with very high creatinine clearance.

Lacroix JM, Lamothe F, Malouin F. Role of Bacteroides bivius beta-lactamase in beta-lactam susceptibility. Antimicrob Agents Chemother. 1984 Nov;26(5):694-8. doi: 10.1128/AAC.26.5.694.

Abstract.  The susceptibility of 46 clinical isolates of Bacteroides bivius to amoxicillin, cefotaxime, cefoxitin, ceftizoxime, cephaloridine, cephalothin, moxalactam, penicillin G, amoxicillin plus clavulanic acid in a ratio of 2:1, carbenicillin, cefamandole, and ceftazidime was determined by an agar dilution technique.

Becopoulos T, Georgoulias D, Constantinides C, Stathakis H, Kosmidis J. Acute prostatitis: which antibiotic to use first. J Chemother. 1990 Aug;2(4):244-6. doi: 10.1080/1120009x.1990.11739024.

Abstract.  The obtained ratios of prostatic tissue to serum concentrations and the relative antimicrobial activity to local pathogens of each agent indicate that the agent of choice for prostatic disease is netilmicin followed by aztreonam, cefuroxime and the ticarcillin-clavulanic acid combination.