Pyridoxine HCL or Pyridoxine hydrochloride is the hydrochloride salt of pyridoxine, a form of vitamin B₆ and includes pyridoxamine (not resistant to high temperatures), pyridoxine (heat-resistant), pyridoxal (not resistant to high temperatures). It is obtained through industrial synthesis processes from methyl methoxyacetate, ethyl cyanoacetate, acetone, etc. It is soluble in water and is easily destroyed.

The name defines the structure of the molecule

• "Pyridoxine" is one of the forms of vitamin B₆. Vitamin B₆ is essential for the metabolism of amino acids, carbohydrates, and lipids in the human body.
• "Hydrochloride" indicates that the molecule has been converted into its salt form using hydrochloric acid. This is often done to improve the solubility or stability of a compound.

Description of raw materials used in production

• 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine is a key precursor for the synthesis of Pyridoxine.
• Hydrochloric acid (HCl) - Used to convert Pyridoxine into Pyridoxine hydrochloride.

Step-by-step summary of industrial chemical synthesis process.

• Preparation of Precursor - 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine is prepared through a series of chemical reactions using appropriate starting compounds.
• Synthesis of Pyridoxine - The precursor is subjected to further chemical reactions to obtain Pyridoxine.
• Conversion - The formed Pyridoxine is treated with hydrochloric acid to convert it into Pyridoxine hydrochloride.
• Crystallization - Pyridoxine hydrochloride is made to crystallize out from the solvent.
• Filtration - The crystalline solid is separated from the liquid through filtration.
• Drying - The solid is dried to remove any traces of solvent.
• Quality Control - The final product undergoes various quality checks to ensure it meets specifications.

It appears as a white powder with fine crystals. Soluble in water, easily destroyed by alkalis or light.

Where it is found

In nature, it is found in vegetables, rice bran, yeast, fat, molasses, etc.

What it is used for and where

Pyridoxine hydrochloride acts in the metabolism of amino acids, carbohydrates and fats, being a co-factor in many physiological properties, including haemoglobin.

Dietary supplements. Often combined with melatonin to strengthen the body, prevent skin diseases, nervous disorders such as depression and to prevent ageing of tissues and organs. Relieves nocturnal muscle spasms, cramps. And for all cases of malnutrition.

Cosmetics

It is included in cosmetic body care products for its protective action on the skin by exerting an anti-ageing action on epithelial cells. It is an absorber of ultraviolet rays. and is a co-adjuvant in hair growth.

Antistatic agent. Static electricity build-up has a direct influence on products and causes electrostatic adsorption. The antistatic ingredient reduces static build-up and surface resistivity on the surface of the skin and hair.

Hair conditioning agent. A significant number of ingredients with specific and targeted purposes may co-exist in hair shampoo formulations: cleansers, conditioners, thickeners, matting agents, sequestering agents, fragrances, preservatives, special additives. However, the indispensable ingredients are the cleansers and conditioners as they are necessary and sufficient for hair cleansing and manageability. The others act as commercial and non-essential auxiliaries such as: appearance, fragrance, colouring, etc. Hair conditioning agents have the task of increasing shine, manageability and volume, and reducing static electricity, especially after treatments such as colouring, ironing, waving, drying and brushing. They are, in practice, dispersants that may contain cationic surfactants, thickeners, emollients, polymers. The typology of hair conditioning agents includes: intensive conditioners, instant conditioners, thickening conditioners, drying conditioners. They can perform their task generally accompanied by other different ingredients.

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Plastics

In the treatment of polycaprolactam products, nylon improves thermal stability.

Commercial applications

Dietary Supplement. Pyridoxine Hydrochloride is often used as a source of Vitamin B₆ in dietary supplements.

Treatment for Vitamin B₆ Deficiency. Prescribed to treat or prevent a deficiency of Vitamin B₆.

Cosmetics and Skin Care Products. Used in some skin care products to promote skin health.

Treatment of Metabolic Disorders. Used in medical treatments for conditions like hyperhomocysteinemia.

Ingredient in Pharmaceutical Products. Included in some pharmaceutical formulations for its beneficial properties.

Pyridoxyne hydrochloride studies

Caratteristiche tipiche ottimali del prodotto commerciale Pyridoxine hydrochloride

Appearance	White powder in fine crystals
Density	1.2784
Boiling Point	491.9ºC at 760 mmHg
Melting Point	214-215 °C
Flash Point	251.3ºC
Purity ≤	99.0%
Residual solvent ethanol	NMT 0.3%
Chloride content	16.9~17.5%
Water content  ≤	1.0%
Total plate count ≤	1000 cfu/g
Yeast & mold ≤	100 cfu/g
Los on drying ≤	2.0%
Heavy metals, ppm ≤	1.0%
PSA	73.58000
Sulphated ash ≤	0.5%/1g
Water Solubility	0.1 g/mL (20ºC)
LogP	0.88220
Vapour Density vs air	7.1
Index of Refraction	1.5800
Storage	2-8°C
Safety

• Molecular Formula  C₈H₁₂ClNO₃       C₈H₁₁NO₃ · HCl
• Molecular Weight     205.64 g/mol
• Exact Mass   205.050568
• CAS  58-56-0
• UNII    68Y4CF58BV
• EC Number   200-386-2    232-503-8
• DSSTox Substance ID DTXSID6030780    DTXSID1040792
• IUPAC  4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride
• InChI=1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H  
• InChl Key      ZUFQODAHGAHPFQ-UHFFFAOYSA-N
• SMILES   CC1=NC=C(C(=C1O)CO)CO.Cl
• MDL number  MFCD00012807
• PubChem Substance ID    329750872
• ChEBI  30961
• NACRES    NA.24  
• NSC   36225
• RTECS   UV1350000  
• NCI   C48030
• Beilstein   3632435

Synonyms:

• Pyridoxine HCl
• Pyridoxol hydrochloride