Compendium of the most significant studies with reference to properties, intake, effects.

Reading SA. Chromium picolinate. J Fla Med Assoc. 1996 Jan;83(1):29-31.

Abstract. Analogues of picolinic acid have been shown to induce profound alterations in the metabolism of serotonin, dopamine, and norepnephrine in brain. Thus, caution should be used with chromium picolinate supplements especially by individuals prone to behavioral disorders.

Sartore G, Ragazzi E, Antonello G, Cosma C, Lapolla A. Effect of a New Formulation of Nutraceuticals as an Add-On to Metformin Monotherapy for Patients with Type 2 Diabetes and Suboptimal Glycemic Control: A Randomized Controlled Trial. Nutrients. 2021 Jul 11;13(7):2373. doi: 10.3390/nu13072373.

Abstract. The aim of the study was to evaluate the overall biohumoral and metabolic effects of a 12-week add-on therapy consisting of a new nutraceutical formulation (BHC) based on berberine, hesperidin, and chromium picolinate in type 2 diabetes mellitus (T2D) patients with suboptimal glycemic compensation receiving metformin.

Derosa G, D'Angelo A, Maffioli P. Metabolic Actions of a Supplement of Ilex Paraguariensis (An Extract of the Leaf Standardized to 2% I-Deoxinojirimcina), White Mulberry and Chromium Picolinate in Nondiabetic Subects with Dysglycemia: A Randomized Trial. Life (Basel). 2021 Jul 18;11(7):709. doi: 10.3390/life11070709.

Abstract. To prove if a nutraceutical containing Ilex paraguariensis (Ilex L. spp. Aquifoliales) (an extract of the leaf standardized to 2% I-deoxinojirimcina), white mulberry (Morus spp., Moraceae), and chromium picolinate can be effective in improving glycemic status in subject with dysglycemia.

Tian H, Guo X, Wang X, He Z, Sun R, Ge S, Zhang Z. Chromium picolinate supplementation for overweight or obese adults. Cochrane Database Syst Rev. 2013 Nov 29;2013(11):CD010063. doi: 10.1002/14651858.CD010063.pub2.

Abstract. To assess the effects of Chromium picolinate  supplementation in overweight or obese people.

Cerulli J, Grabe DW, Gauthier I, Malone M, McGoldrick MD. Chromium picolinate toxicity. Ann Pharmacother. 1998 Apr;32(4):428-31. doi: 10.1345/aph.17327.

Abstract. To describe a case of toxicity secondary to chronic ingestion of 6-12 times the recommended daily allowance of over-the-counter (OTC) chromium picolinate.

Feiner JJ, McNurlan MA, Ferris RE, Mynarcik DC, Gelato MC. Chromium picolinate for insulin resistance in subjects with HIV disease: a pilot study. Diabetes Obes Metab. 2008 Feb;10(2):151-8. doi: 10.1111/j.1463-1326.2006.00681.x.

Abstract. The objective was to study the efficacy and safety of chromium picolinate as a treatment of insulin resistance in subjects infected with HIV.

Bani Hassan E, Doyle N, Bienvenu JG, Stent A, Guillemin GJ, Duque G. Evaluating the toxicity of escalating dose of oral picolinic acid in Sprague-Dawley rats. Toxicology. 2021 Oct;462:152960. doi: 10.1016/j.tox.2021.152960.

Abstract. In summary, very high doses of PIC (≥500 mg/kg/day) were vascular-neurotoxic. Possible future experiments must consider significantly lower doses.

Dworzański W, Cholewińska E, Fotschki B, Juśkiewicz J, Listos P, Ognik K. Assessment of DNA Methylation and Oxidative Changes in the Heart and Brain of Rats Receiving a High-Fat Diet Supplemented with Various Forms of Chromium. Animals (Basel). 2020 Aug 21;10(9):1470. doi: 10.3390/ani10091470.

Abstract. It was established that the use of chromium to supplement a high-fat diet intensifies the negative epigenetic and oxidative changes in the heart and brain, especially in the case of chromium nanoparticles.