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 | "Descrizione" by Al222 (19776 pt) | 2022-Jan-17 18:01 |
| Evaluation | N. Experts | Evaluation | N. Experts |
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Diethylene glycol monoethyl ether is a chemical compound, hydroxypolyether, an ether glycol, primary alcohol derived from ethylene oxide.
It occurs as a colourless transparent liquid with a mild, ethereal odour. High boiling point solvent, soluble in water.
What it is used for and where
Pharmaceuticals. Diethylene glycol monoethyl ether is used as a solvent excipient and transdermal permeation enhancer in a number of injectable, transdermal and oral products in the pharmaceutical industry and, in particular, has the prerogative of improving skin deposition with poorly soluble drugs such as corticosteroids and griseofulvin (1).
An intermediate chemical compound used in the preparation of organic compounds and analytical chemical reagents.
Cosmetics. Monoethyl ether diethylene glycol is an excipient approved by the FDA (Food and Drugs Administration) for use in cosmetics where it is generally used as a solvent.
Other uses
Textiles. Solvent and emulsion stabiliser in fibre dyeing processes.
Solvent in industrial processes of leather, synthetic resins, paints, spray paints, wood, petroleum sulphonic acid.
Safety
In this 2019 evaluation aimed at clarifying the doubts of the Scientific Committee on Consumer Products (SCCP) which, having examined Diethylene Glycol Monoethyl Ether (DEGEE) had found the toxicological reports submitted at the time to be unsatisfactory, the researchers found that the nephrotoxic potential of DEGEE cannot be excluded. Tests were carried out on single acute exposure of DEGEE intraperitoneally in Swiss albino mice and, in addition, a 28-day subchronic exposure study was conducted in which DEGEE was administered orally, once daily (2).
Diethylene glycol monoethyl ether studies
Typical optimal commercial product characteristics Diethylene Glycol Monoethyl Ether
| Appearance | Colourless transparent liquid |
| Boiling Point | 202.0±0.0 °C at 760 mmHg |
| Melting Point | -80°C |
| Density | 1.0±0.1 g/cm3 0.999g/mL at 25°C |
| Flash Point | 96.1±0.0°C |
| Content (GC)% | ≥ 99 |
| Acidity (acetic acid)% | ≤ 0.02 |
| Specific gravity(d420) | 0.989±0.005 |
| Distillation range (℃ / 760mmhg) | 194.0-205.0 |
| Vapour Pressure | 0.1±0.8 mmHg at 25°C 0.12mmHg(20°C) |
| Vapour density | 4.63 |
| Index of Refraction | 1.420 |
| PSA | 38.69000 |
| LogP | -0.62 |
| Storage | Below +30°C |
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Synonyms:
References____________________________________________________________________
(1) Ritschel WA, Panchagnula R, Stemmer K, Ashraf M. Development of an intracutaneous depot for drugs. Binding, drug accumulation and retention studies, and mechanism of depot. Skin Pharmacol. 1991;4(4):235-45.
(2) Srivastava S, Mishra S, Dewangan J, Divakar A, Gupta N, Kalleti N, Mugale MN, Kumar S, Sharma S, Rath SK. Safety assessment of the pharmacological excipient, diethylene glycol monoethyl ether (DEGEE), using in vitro and in vivo systems. Daru. 2019 Jun;27(1):219-231. doi: 10.1007/s40199-019-00264-5.
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