Compendium of the most significant studies with reference to properties, intake, effects.

Legendre JY, Schnitzler I, Li QY, Hausen C, Huart M, Luengo GS, Abella ML, Roreger M. Formulation, characterization, and efficacy of an adenosine-containing dissolvable film for a localized anti-wrinkle effect. J Cosmet Sci. 2007 Mar-Apr;58(2):147-55.

Abstract. A randomized, placebo-controlled, investigator-blind study was conducted in female volunteers to assess the efficacy of the 1% adenosine-containing dissolvable film.

Simpson RE, Phillis JW. Adenosine in exercise adaptation. Br J Sports Med. 1992 Mar;26(1):54-8. doi: 10.1136/bjsm.26.1.54.

Abstract. By influencing the regulation of the mechanisms of angiogenesis, erythropoietin production, blood flow, myocardial glucose uptake, glycogenolysis, systolic blood pressure, respiration, plasma norepinephrine and epinephrine levels, adenosine may exert a significant effect on the body's adaptation response to exercise.

Masino SA, Kawamura M Jr, Cote JL, Williams RB, Ruskin DN. Adenosine and autism: a spectrum of opportunities. Neuropharmacology. 2013 May;68:116-21. doi: 10.1016/j.neuropharm.2012.08.013.

Abstract. Because adenosine is a broad homeostatic regulator of cell function and nervous system activity, increasing adenosine's influence might be a new therapeutic target for autism with multiple beneficial effects. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'.

Mou KJ, Shen KF, Li YL, Wu ZF, Duan W. Adenosine A2A Receptor in Bone Marrow-Derived Cells Mediated Macrophages M2 Polarization via PPARγ-P65 Pathway in Chronic Hypoperfusion Situation. Front Aging Neurosci. 2022 Jan 3;13:792733. doi: 10.3389/fnagi.2021.792733.

Abstract. The role of adenosine A2A receptor (A2AR) in the ischemic white matter damage induced by chronic cerebral hypoperfusion remains obscure. Here we investigated the role of A2AR in the process of macrophage polarizations in the white matter damage induced by chronic cerebral hypoperfusion and explored the involved signaling pathways.

Pelleg A, Porter RS. The pharmacology of adenosine. Pharmacotherapy. 1990;10(3):157-74.

Abstract.   Exogenous adenosine has a wide spectrum of effects in experimental animal models as well as humans. The pharmacokinetics, pharmacodynamics, and the interaction of adenosine with other drugs are reviewed.

Kaster MP, Machado DG, Santos AR, Rodrigues AL. Involvement of NMDA receptors in the antidepressant-like action of adenosine. Pharmacol Rep. 2012;64(3):706-13. doi: 10.1016/s1734-1140(12)70865-4.

Abstract. In this work, the contribution of NMDA receptors to the antidepressant-like effect of adenosine in the forced swimming test (FST) was investigated.

Nakav S, Kachko L, Vorobiov M, Rogachev B, Chaimovitz C, Zlotnik M, Douvdevani A. Blocking adenosine A2A receptor reduces peritoneal fibrosis in two independent experimental models. Nephrol Dial Transplant. 2009 Aug;24(8):2392-9. doi: 10.1093/ndt/gfp041.

Abstract. Long-term peritoneal dialysis (PD) is associated with peritoneal fibrosis and loss of function. It has been shown that activation of the adenosine A(2A) receptor (A(2A)R) promotes tissue repair, wound healing and extracellular matrix (ECM) production. We have previously shown that adenosine is a potent regulator of inflammation in the peritoneum. In the current study, we explored the role of adenosine and the A(2A)R in two experimental models.