Compendio degli studi più significativi con riferimento a proprietà, assunzione, effetti.

E. Lee,S. An,S.-A. Cho,Y. Yun,J. Han,Y. K. Hwang,H. K. Kim,T. R. Lee  The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols  doi.org/10.1111/j.1468-2494.2011.00646.x

Abstract.  To investigate the influence of alkane chain length on the skin irritation potential of 1,2-alkanediols. 

Lee E, An S, Cho SA, Yun Y, Han J, Hwang YK, Kim HK, Lee TR. The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols. Int J Cosmet Sci. 2011 Oct;33(5):421-5. doi: 10.1111/j.1468-2494.2011.00646.x.

Abstract.  To investigate the influence of alkane chain length on the skin irritation potential of 1,2-alkanediols. 

Seino H, Kawaguchi N, Arai Y, Ozawa N, Hamada K, Nagao N. Investigation of partially myristoylated carboxymethyl chitosan, an amphoteric-amphiphilic chitosan derivative, as a new material for cosmetic and dermal application. J Cosmet Dermatol. 2021 Jul;20(7):2332-2340. doi: 10.1111/jocd.13833.

Abstract. This study aimed to evaluate the usefulness of partially myristoylated carboxymethyl chitosan, an amphoteric-amphiphilic chitosan derivative, as a new material for cosmetics in the absence of a surfactant comprising an anionic polymer.

Warner KS, Li SK, Higuchi WI. Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement. J Pharm Sci. 2001 Aug;90(8):1143-53. doi: 10.1002/jps.1068.

Abstract.  The purpose of the present study was to further investigate what was believed to be a somewhat surprising finding, and two additional homologous series, the 1,2-alkanediols and N,N-dimethylalkanamides, were selected for study as enhancers.

Chularojanamontri L, Tuchinda P, Kulthanan K, Varothai S, Winayanuwattikun W. A double-blinded, randomized, vehicle-controlled study to access skin tolerability and efficacy of an anti-inflammatory moisturizer in treatment of acne with 0.1% adapalene gel. J Dermatolog Treat. 2016;27(2):140-5. doi: 10.3109/09546634.2015.1079298.

Abstract. This study aimed to compare tolerability and efficacy of moisturizers containing licochalcone A, l-carnitine and 1,2-decanediol (active formulation) with a placebo in mild to moderate severe acne in Asian subjects.

Angelova-Fischer I, Rippke F, Fischer TW, Neufang G, Zillikens D. A double-blind, randomized, vehicle-controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne. J Eur Acad Dermatol Venereol. 2013 Jul;27 Suppl 2:6-11. doi: 10.1111/jdv.12168.

Abstract. Cosmetic formulations based on a combination of active compounds with in vitro proven anti-inflammatory, sebum regulating and P. acnes reducing properties may therefore contribute to improve the clinical signs and associated burden of disease.