Compendium of the most significant studies with reference to properties, intake, effects.

Tarazona JV, Court-Marques D, Tiramani M, Reich H, Pfeil R, Istace F, Crivellente F. Glyphosate toxicity and carcinogenicity: a review of the scientific basis of the European Union assessment and its differences with IARC. Arch Toxicol. 2017 Aug;91(8):2723-2743. doi: 10.1007/s00204-017-1962-5.

Abstract. This review presents the scientific basis of the glyphosate health assessment conducted within the European Union (EU) renewal process, and explains the differences in the carcinogenicity assessment with IARC. Use of different data sets, particularly on long-term toxicity/carcinogenicity in rodents, could partially explain the divergent views; but methodological differences in the evaluation of the available evidence have been identified.

Peillex C, Pelletier M. The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity. J Immunotoxicol. 2020 Dec;17(1):163-174. doi: 10.1080/1547691X.2020.1804492.

Abstract. This review details the effects of glyphosate and glyphosate-based herbicides on fish and mammal health, focusing on the immune system. Increasing evidence shows that glyphosate and glyphosate-based herbicides exhibit cytotoxic and genotoxic effects, increase oxidative stress, disrupt the estrogen pathway, impair some cerebral functions, and allegedly correlate with some cancers.

Duke SO. The history and current status of glyphosate. Pest Manag Sci. 2018 May;74(5):1027-1034. doi: 10.1002/ps.4652.

Abstract. It is a high use rate, non-selective herbicide that translocates primarily to metabolic sinks, killing meristematic tissues away from the application site. Its phloem-mobile properties and slow action in killing weeds allow the herbicide to move throughout the plant to kill all meristems, making it effective for perennial weed control. Since commercialization in 1974, its use has grown to dominate the herbicide market. 

Milesi MM, Lorenz V, Durando M, Rossetti MF, Varayoud J. Glyphosate Herbicide: Reproductive Outcomes and Multigenerational Effects. Front Endocrinol (Lausanne). 2021 Jul 7;12:672532. doi: 10.3389/fendo.2021.672532. 

Abstract. Indiscriminate and negligent use of GBHs has promoted the emergence of glyphosate resistant weeds, and consequently the rise in the use of these herbicides.

Soares D, Silva L, Duarte S, Pena A, Pereira A. Glyphosate Use, Toxicity and Occurrence in Food. Foods. 2021 Nov 12;10(11):2785. doi: 10.3390/foods10112785.

Abstract. This work aims to review the glyphosate use, toxicity and occurrence in diverse food samples, which, in certain cases, occurs at violative levels. The incidence of glyphosate at levels above those legally allowed and the suspected toxic effects of this compound raise awareness regarding public health.

Sammons, R. D., & Gaines, T. A. (2014). Glyphosate resistance: state of knowledge. Pest management science, 70(9), 1367-1377.

Abstract. Studies of mechanisms of resistance to glyphosate have increased current understanding of herbicide resistance mechanisms. Thus far, single-codon non-synonymous mutations of EPSPS (5-enolypyruvylshikimate-3-phosphate synthase) have been rare and, relative to other herbicide mode of action target-site mutations, unconventionally weak in magnitude for resistance to glyphosate.

Wang, X., Lu, Q., Guo, J., Ares, I., Martínez, M., Martínez-Larrañaga, M. R., ... & Martínez, M. A. (2022). Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology. Annual review of pharmacology and toxicology, 62, 617-639.

Abstract. This review provides a comprehensive introduction to the toxicity of GLYP and, for the first time, systematically summarizes the toxicity mechanism of GLYP from the perspective of oxidative stress, including GLYP-mediated oxidative damage, changes in antioxidant status, altered signaling pathways, and the regulation of oxidative stress by exogenous substances. 

Strilbyska, O. M., Tsiumpala, S. A., Kozachyshyn, I. I., Strutynska, T., Burdyliuk, N., Lushchak, V. I., & Lushchak, O. (2022). The effects of low-toxic herbicide Roundup and glyphosate on mitochondria. EXCLI journal, 21, 183.

Abstract. Despite it is claimed to be low toxic for not-target organisms, due to its broad application Roundup and products of its degradation were detected in organisms of diverse animals and humans. In this review, we describe animal and human studies of general adverse effects of Roundup and its principal substance glyphosate with focus on endocrine disruption, oxidative stress and behavioral disorders.

De Maria, M., Kroll, K. J., Yu, F., Nouri, M. Z., Silva-Sanchez, C., Perez, J. G., ... & Denslow, N. D. (2022). Endocrine, immune and renal toxicity in male largemouth bass after chronic exposure to glyphosate and Rodeo®. Aquatic Toxicology, 106142.

Abstract.  We exposed adult male largemouth bass for 21 days to two doses of glyphosate and Rodeo® (chemically equivalent concentration of glyphosate) at 0.5 mg L−1 and 10 mg L−1 and to a clean water control (n=4 fish/tank in quadruplicate). 

Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol. 2013 Dec;6(4):159-84. doi: 10.2478/intox-2013-0026.

Abstract. Here, we propose that glyphosate, the active ingredient in the herbicide, Roundup®, is the most important causal factor in this epidemic. Fish exposed to glyphosate develop digestive problems that are reminiscent of celiac disease. Celiac disease is associated with imbalances in gut bacteria that can be fully explained by the known effects of glyphosate on gut bacteria.