Cetearyl glucoside.  Compendium of the most significant studies with reference to properties, intake, effects.

Pantelic, Ivana, ed. Alkyl Polyglucosides: From natural-origin surfactants to prospective delivery systems. Woodhead Publishing, 2014.

Abstract. Sugar-based surfactants represent a growing market. Among these, Alkyl Polyglucosides produced from vegetable oil and starch, are in demand.

Djuris J, Vasiljevic D, Jokic S, Ibric S. Application of D-optimal experimental design method to optimize the formulation of O/W cosmetic emulsions. Int J Cosmet Sci. 2014 Feb;36(1):79-87. doi: 10.1111/ics.12099. 

Abstract.  This study investigates the application of D-optimal mixture experimental design in optimization of O/W cosmetic emulsions.

Savić S, Weber C, Savić MM, Müller-Goymann C. Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance. Int J Pharm. 2009 Nov 3;381(2):220-30. doi: 10.1016/j.ijpharm.2009.07.007. 

Abstract. This study focuses on the properties of topical vehicles based on alkylpolyglucoside natural surfactant-mixed emulsifier, cetearyl glucoside and cetearyl alcohol, in order to propose their use as "ready to use" pharmaceutical bases for a number of model drugs. We were interested to investigate how the alternative use of three lipophilic excipients (Ph. Eur. 6.0), differing in their polarity indexes (medium chain triglycerides (MG), decyl oleate (DO), and isopropyl myristate (IPM), respectively), affects the colloidal structure of the alkylpolyglucoside-based vehicles and in vitro permeation profiles of two model drugs: diclofenac sodium (DC) and caffeine (CF), both sparingly soluble in water. Finally, we aimed to evaluate the safety profile of such vehicles in vitro (acute skin irritation test using a cytotoxicity assay), comparing it with in vivo data obtained by the methods of skin bioengineering. The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type.

Bhoyrul, Bevin, et al. "Patch testing with alkyl glucosides: Concomitant reactions are common but not ubiquitous." Contact dermatitis 80.5 (2019): 286-290.

Abstract. Alkyl glucosides contitute a family of mild surfactants that are increasingly being used in a wide range of cosmetics and household products. Contact allergy to alkyl glucosides may be more frequent than previously suspected, especially in atopic patients. Objectives. To investigate the frequency of contact allergy to alkyl glucosides, and to identify concomitant reactivity.

Savic S, Weber C, Tamburic S, Savic M, Müller-Goymann C. Topical vehicles based on natural surfactant/fatty alcohols mixed emulsifier: The influence of two polyols on the colloidal structure and in vitro/in vivo skin performance. J Pharm Sci. 2009 Jun;98(6):2073-90. doi: 10.1002/jps.21591.

Abstract. There is a growing need for in-depth research into new skin- and environment-friendly surfactants, such as alkylpolyglucosides. The aim of this study was to assess whether, to which extent and by what mechanism the two commonly used hydrophilic excipients, propylene glycol (PG) and glycerol (GL), affect the colloidal structure of emulsions formed by a natural mixed emulsifier, cetearyl glucoside and cetearyl alcohol. 

Montenegro, L., Carbone, C., Paolino, D., Drago, R., Stancampiano, A. H., & Puglisi, G. (2008). In vitro skin permeation of sunscreen agents from O/W emulsions. International journal of cosmetic science, 30(1), 57-65.

Abstract. The effects of different emulsifiers on the in vitro permeation through human skin of two sunscreen agents [octylmethoxycinnamate (OMC) and butylmethoxydibenzoylmethane (BMBM)] were investigated from O/W emulsions.

Savic, S., Vuleta, G., Daniels, R., & Müller-Goymann, C. C. (2005). Colloidal microstructure of binary systems and model creams stabilized with an alkylpolyglucoside non-ionic emulsifier. Colloid and Polymer Science, 283(4), 439-451.

Abstract. The aim of this study was to examine the lyotropic potential of an alkylpolyglucoside mixed emulsifier (Cetearyl glucoside&Cetearyl alcohol), which belongs to the new generation of natural (sugar) surfactants, and to elaborate the potential stabilization mechanism and relation between the colloid microstructure and water distribution within the systems.

Baudy A, Dereure O, Du-Thanh A, Raison-Peyron N. Allergic contact dermatitis in response to cetearyl glucoside from a topical drug. Contact Dermatitis. 2022 Feb;86(2):125-127. doi: 10.1111/cod.13985.