Chlorhexidine digluconate is a chemical compound, a cationic biguanide compound, gluconate salt of chlorhexidine.

It appears as a transparent liquid.

What it is used for and where

Take only under medical supervision

Chemical intermediate. Broad spectrum microbicide against pyogenic bacteria, hospital infection pathogens, airborne pathogens, intestinal pathogens, pathogenic yeasts and fungi.

Medical

Widely used as a sterilisation antiseptic against both gram-positive and gram-negative bacteria. It has been found to have anti-biofilm activity (1), in vivo bactericidal efficacy during surgical hand scrub preparations (2), increased residual antiseptic activity on the skin after application (3), increased residual antiseptic activity on the skin after application. Effective in 0.02% ophthalmic solutions (4).

Like all drugs it can cause side effects. Always ask the physician.

Chlorhexidine digluconate studies

Appearance	Transparent clear liquid
Boiling Point	699.3ºC at 760 mmHg
Melting Point	134ºC
Flash Point	376.7ºC
Density	1.06 g/mL at 25 °C
pH	5.5-7.0
Residue on ignition	≤0.1%
Water Solubility	50% (w/v)
Assay	19.0-21.0%
Safety

• Molecular Formula  C₃₄H₅₄Cl₂N₁₀O₁₄
• Molecular Weight     897.8
• CAS  18472-51-0
• UNII    MOR84MUD8E
• EC Number   242-354-0
• DSSTox Substance ID  DTXSID5034519
• IUPAC  (1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
• InChI=1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1  
• InChl Key      YZIYKJHYYHPJIB-UUPCJSQJSA-N
• SMILES C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl.C(C(C(C(C(C(=O)O)O)O)O)O)O.C(C(C(C(C(C(=O)O)O)O)O)O)O
• MDL number  MFCD00083599
• PubChem Substance ID    329775206
• ChEBI  28312
• RXCUI  20791    
• NACRES NA.83  
• NCI   C47974

Synonyms:

• 1,6-Bis(N⁵-[p-chlorophenyl]-N¹-biguanido)hexane; 
• 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

References_______________________________________________________________________

(1) Jeyakumar J, Sculean A, Eick S. Anti-biofilm Activity of Oral Health-care Products Containing Chlorhexidine Digluconate and Citrox. Oral Health Prev Dent. 2020 Oct 27;18(1):981-990. doi: 10.3290/j.ohpd.a45437.

(2) Labadie JC, Kampf G, Lejeune B, Exner M, Cottron O, Girard R, Orlick M, Goetz ML, Darbord JC, Kramer A. Recommendations for surgical hand disinfection -- requirements, implementation and need for research. A proposal by representatives of the SFHH, DGHM and DGKH for a European discussion. J Hosp Infect. 2002 Aug;51(4):312-5. doi: 10.1053/jhin.2002.1243. 

(3) Maiwald M, Chan ES. The forgotten role of alcohol: a systematic review and meta-analysis of the clinical efficacy and perceived role of chlorhexidine in skin antisepsis. PLoS One. 2012;7(9):e44277. doi: 10.1371/journal.pone.0044277.

(4) Lin SC, Huang CF, Shen LJ, Wang HJ, Lin CY, Wu FL. Formulation and stability of an extemporaneous 0.02% chlorhexidine digluconate ophthalmic solution. J Formos Med Assoc. 2015 Dec;114(12):1162-9. doi: 10.1016/j.jfma.2014.08.003.