Compendium of the most significant studies with reference to properties, intake, effects.

Ocaña A, Gómez-Asensio C, Arranz-Gutiérrez E, Torres C, Señoráns FJ, Reglero G. In vitro study of the effect of diesterified alkoxyglycerols with conjugated linoleic acid on adipocyte inflammatory mediators. Lipids Health Dis. 2010 Apr 6;9:36. doi: 10.1186/1476-511X-9-36.

Abstract. In this study we examined the anti-inflammatory activity and mechanisms of modified alkoxyglycerols. 

Enns GM, Ammous Z, Himes RW, Nogueira J, Palle S, Sullivan M, Ramirez C. Diagnostic challenges and disease management in patients with a mild Zellweger spectrum disorder phenotype. Mol Genet Metab. 2021 Nov;134(3):217-222. doi: 10.1016/j.ymgme.2021.09.007. 

Abstract. Peroxisome Biogenesis Disorders-Zellweger spectrum disorder (PBD-ZSD) is a rare, autosomal recessive peroxisome biogenesis disorder that presents with variable symptoms. 

Mischenko P, Egoraeva A, Tyrtyshnaia A, Kasyanov S, Ponomarenko A, Manzhulo I. Chimyl Alcohol Exhibits Proinflammatory Activity in vivo and in vitro. Cells Tissues Organs. 2022;211(1):30-40. doi: 10.1159/000519832.

Abstract. Marine organisms are among the prominent and abundant sources of 1-O-alkyl-sn-glycerols, including chimyl alcohol (CA), batyl alcohol and selachyl alcohol.

Das AK, Holmes RD, Wilson GN, Hajra AK. Dietary ether lipid incorporation into tissue plasmalogens of humans and rodents. Lipids. 1992 Jun;27(6):401-5. doi: 10.1007/BF02536379.

Abstract. Chronic feeding of 1-O-octadecyl-sn-glycerol (batyl alcohol) to patients suffering from congenital deficiency in tissue ether glycerolipids showed an increase in the plasmalogens content of their erythrocytes. However, nothing is known about the ether lipid content of other tissues in these patients. Feeding 1-O-heptadecyl-sn-glycerol to young rats showed that this uncommon ether lipid was incorporated to a high extent into the plasmalogens of all tissues except brain. Comparative studies with other precursors, such as 3-O-heptadecyl-sn-glycerol, heptadecanol and heptadecanoic acid, indicated a stereospecific incorporation of the dietary 1-O-alkyl-sn-glycerols into tissue plasmalogens without cleavage of the ether bond. Dietary ether lipids were also shown to be transferred from mothers to suckling rats, but not from pregnant rats to fetuses. The implication of these results to possible dietary ether lipid therapy for patients suffering from peroxisomal disorders is discussed.

Chen Z, Xie X, Jiang N, Li J, Shen L, Zhang Y. CCR5 signaling promotes lipopolysaccharide-induced macrophage recruitment and alveolar developmental arrest. Cell Death Dis. 2021 Feb 15;12(2):184. doi: 10.1038/s41419-021-03464-7.

Abstract. The pathogenesis of bronchopulmonary dysplasia (BPD), involves inflammatory, mechanisms that are not fully characterized. Here we report that overexpression of C-C chemokine receptor 5 (CCR5) and its ligands is associated with BPD development.

Tham YK, Huynh K, Mellett NA, Henstridge DC, Kiriazis H, Ooi JYY, Matsumoto A, Patterson NL, Sadoshima J, Meikle PJ, McMullen JR. Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Mar;1863(3):219-234. doi: 10.1016/j.bbalip.2017.12.003. 

Abstract. The aim of this study was to determine whether distinct lipids are regulated in settings of physiological and pathological remodeling, and if so, whether modulation of differentially regulated lipids could modulate heart size and function.

Zhang M, Sun S, Tang N, Cai W, Qian L. Oral administration of alkylglycerols differentially modulates high-fat diet-induced obesity and insulin resistance in mice. Evid Based Complement Alternat Med. 2013;2013:834027. doi: 10.1155/2013/834027.

Abstract. The purpose of the present study was to investigate the effect of two Alkylglycerols   isoforms on obesity and insulin resistance in mice fed high-fat (HF) diet.