Compendium of the most significant studies with reference to properties, intake, effects.

Velasco, M. V. R., Sarruf, F. D., Salgado-Santos, I. M. N., Haroutiounian-Filho, C. A., Kaneko, T. M., & Baby, A. R. (2008). Broad spectrum bioactive sunscreens. International journal of pharmaceutics, 363(1-2), 50-57.

Abstract.  The objective of the present research work was to develop bioactive sunscreen delivery systems containing rutin, Passiflora incarnata L. and Plantago lanceolata extracts associated or not with organic and inorganic UV filters. 

Pinto, C. A. S. D. O., Lopes, P. S., Sarruf, F. D., Polakiewicz, B., Kaneko, T. M., Baby, A. R., & Velasco, M. V. R. (2011). Comparative study of the stability of free and modified papain incorporated in topical formulations. Brazilian Journal of Pharmaceutical Sciences, 47(4), 751-760.

Abstract.  Papain is an enzyme used in topical formulations as a proteolytic debriding agent for the treatment of open, extensive wounds and burnings. It is also employed as an enhancer for cutaneous permeation of active compounds, chemical peeling and as a progressive depilatory agent. The stability of formulations containing enzymes is not easy. In this research, papain was modified with polyethylene glycol in order to increase the stability of the formulations. 

da Silva, A. C., Paiva, J. P., Diniz, R. R., Dos Anjos, V. M., Silva, A. B. S., Pinto, A. V., ... & Santos, B. A. M. (2019). Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens. Journal of Photochemistry and Photobiology B: Biology, 193, 162-171.

Abstract. This study was designed to investigate the photoprotective potential of olive leaves extract standardized for oleuropein performing a set of in vitro and in silico tools as an innovative approach, highlighting yeast assays, in vitro Sun Protection Factor (SPF) and molecular modelling studies of UV absorption.

Fernandes, É. M., de Brito Damasceno, G. A., Ferrari, M., & de Azevedo, E. P. (2015). Incremento na dissolução da caffeine em base de ammonium acryloyldimethyltaurate/vp copolymer: desenvolvimento farmacotécnico de géis anti-celulite. Revista de Ciências Farmacêuticas Básica e Aplicada, 36(1).

Abstract. A hidrolipodistrofia ginóide (HLDG), popularmente conhecida como “celulite”, consiste em uma alteração patológica do tecido adiposo e da função venolinfática. Géis contendo caffeine tem sido empregados no tratamento não-invasivo da HLDG, oferecendo resultados satisfatórios a baixos custos. Devido a baixa hidrossolubilidade da caffeine, este gel apresenta como principal inconveniente a formação de precipitados/ grumos, oriundos da precipitação da caffeine na base hidrofílica (gel). Este trabalho tem como objetivo o incremento na dissolução da caffeine em gel de Ammonium Acryloyldimethyltaurate/VP Copolymer, através da adição de adjuvantes como o citric acid e o sodium benzoate, além de solução hidroalcoólica, empregada como co-solvente da caffeine.

Isaac, V. L. B., Cefali, L. C., Chiari, B. G., Almeida, M. G. J., Ribeiro, H. M., & Correa, M. A. (2013). Effect of various thickening agents on the rheological properties of oil-in-water emulsions containing nonionic emulsifier. Journal of dispersion science and technology, 34(6), 880-885.

Abstract. The knowledge of rheological characteristics can indicate the emulsions properties, thus, nowadays rheology is used in the cosmetic and pharmaceutical industries, even to study the influence of rheological additives on them. 

Nigro, F., Cerqueira, C., Rossi, A., Cardoso, V., Vermelho, A. B., Ricci-Júnior, E., ... & Mansur, C. R. E. (2020). Development, characterization and in vitro toxicity evaluation of nanoemulsion-loaded hydrogel based on copaiba oil and coenzyme Q10. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 586, 124132.

Abstract. In this work, we used copaiba oil, a vegetable oil with properties similar to those of CQ10, to compose oil-in-water (O/W) nanoemulsions with CQ10 (NECQ10) and without it (NECO), for comparative purposes, prepared by ultrasound processing.