Compendium of the most significant studies with reference to properties, intake, effects.

Chen C, Huo JS, Zhuo Q, Li Y, Ma Y, Wang JB, Jia XD. Lipid Accumulation and IL-6 Production in L02 Hepatocytes Induced by Sodium Oleate: Dose and Time Dependence. Biomed Environ Sci. 2021 Dec 20;34(12):998-1004. doi: 10.3967/bes2021.058.

Abstract. To explore interleukin-6 (IL-6) production and characterize lipid accumulation in L02 hepatocytes induced by sodium oleate. 

Zhou S, Zhou W, Dong L, Peng Y, Xie G. Micellization Transformations of Sodium Oleate Induced by Gas Nucleation. Langmuir. 2021 Aug 17;37(32):9701-9710. doi: 10.1021/acs.langmuir.1c01008.

Abstract. The interfacial properties of surfactant solutions are closely related to the micellization of surfactants. Temperature, salt type and concentration, pH, and other parameters affecting the micellization of surfactants have all been extensively investigated previously. However, the effect of dissolved gas on surfactant micellization and associated interfacial properties' transformations is not completely understood yet. In this study, sodium oleate (NaOl) was chosen as the research object, and the role of gas/gas nucleation in NaOl micellization was systematically investigated. 

Tatini D, Raudino M, Ambrosi M, Carretti E, Davidovich I, Talmon Y, Ninham BW, Lo Nostro P. Physicochemical characterization of green sodium oleate-based formulations. Part 1. Structure and rheology. J Colloid Interface Sci. 2021 May 15;590:238-248. doi: 10.1016/j.jcis.2021.01.040.

Abstract. This paper is the first report in which a moderately concentrated (13% w/w) dispersion of NaOL in water is investigated. In fact, at this concentration the phase and rheology behavior of the surfactant remarkably deviates from those of its dilute solutions in water and a significant effect is imparted by the addition of potassium chloride. 

Dong D, Quan E, Yuan X, Xie Q, Li Z, Wu B. Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism. Mol Pharm. 2017 Sep 5;14(9):2864-2874. doi: 10.1021/acs.molpharmaceut.6b00851.

Abstract. Sodium oleate (NaOl), a collector in diaspore flotation, has been widely used for more than 30 years, while its low selectivity becomes an issue under today's process requirement. This study introduced tert dodecyl mercaptan (TDM) together with NaOl as a mixed collector to improve selectivity in diaspore flotation.

Sintov A, Ze'evi A, Uzan R, Nyska A. Influence of pharmaceutical gel vehicles containing oleic acid/sodium oleate combinations on hairless mouse skin, a histological evaluation. Eur J Pharm Biopharm. 1999 May;47(3):299-303. doi: 10.1016/s0939-6411(99)00018-1.

Abstract.  It was seen that the severity and frequency of histological changes in the skin treated with OA-containing vehicles were directly correlated with increased pH/ionization (i.e. decreased OA/sodium oleate ratio) and with overall OA concentration.

Llanos S, Giraldo LJ, Santamaria O, Franco CA, Cortés FB. Effect of Sodium Oleate Surfactant Concentration Grafted onto SiO2 Nanoparticles in Polymer Flooding Processes. ACS Omega. 2018 Dec 28;3(12):18673-18684. doi: 10.1021/acsomega.8b02944.

Abstract. The nanotechnology has been applied recently to increase the efficiency of enhanced oil recovery methods. The main objective of this study is to evaluate the effect of SiO2 nanoparticle functionalization with different loadings of sodium oleate surfactant for polymer flooding processes. The sodium oleate surfactant was synthesized using oleic acid and NaCl. 

Barter PJ, Chang LB, Rajaram OV. Sodium oleate promotes a redistribution of cholesteryl esters from high to low density lipoproteins. Atherosclerosis. 1990 Sep;84(1):13-24. doi: 10.1016/0021-9150(90)90003-2. 

Abstract. Cholesteryl esters readily exchanges between the low density lipoproteins (LDL) and high density lipoproteins (HDL) in human plasma in a process of equilibration catalysed by the cholesteryl ester transfer protein (CETP). In the present studies, in which mixtures of human LDL and HDL have been incubated in vitro with partially pure CETP, it has been found that Na oleate disrupts the CETP-mediated equilibrium between LDL and HDL and promotes a concentration dependent redistribution of cholesteryl esters from HDL to LDL.

Beneventi D, Pugh RJ, Carré B, Gandini A. Surface rheology and foaming properties of sodium oleate and C12(EO)6 aqueous solutions. J Colloid Interface Sci. 2003 Dec 1;268(1):221-9. doi: 10.1016/s0021-9797(03)00724-0. 

Abstract. The dynamic surface tension (DST) and the surface viscoelastic modulus of sodium oleate aqueous solutions at different concentrations were measured using an image analysis tensiometer based on the oscillating bubble technique. The diffusion coefficient of oleate moieties was calculated from DST measurements and the surface viscoelastic modulus using the Langmuir-Szyszkowski and the diffusion-controlled adsorption models. 

Okumura T, Suzuki K, Kumada K, Kobayashi R, Fukuda A, Fujii C, Kohama A. Severe respiratory distress following sodium oleate ingestion. J Toxicol Clin Toxicol. 1998;36(6):587-9. doi: 10.3109/15563659809028053. 

Abstract. Oleic acid and oleate are pulmonary toxins used to create laboratory models of acute respiratory distress syndrome, but there is little information on human toxicity. We report the intentional ingestion of 50 mL sodium oleate 20% by a 22-year-old woman with no symptoms for the first 2 days after ingestion.

Kameshima Y, Sasaki H, Isobe T, Nakajima A, Okada K. Synthesis of composites of sodium oleate/Mg-Al-ascorbic acid-layered double hydroxides for drug delivery applications. Int J Pharm. 2009 Oct 20;381(1):34-9. doi: 10.1016/j.ijpharm.2009.07.021. 

Abstract. Mg-Al-ascorbic acid (ASA)-layered double hydroxides (ASA-LDHs) with Mg/Al=3 were synthesized by ion-exchange, coprecipitation and reconstruction methods. Composites with sodium oleate (SOA)/ASA-LDH were prepared by an ion-exchange method using various concentrations of SOA solutions. 

Guedes IS, Stencel M, Campello AD, do Nascimento AJ. Effect of sodium oleate on oxidative metabolism of isolated mitochondria and submitochondrial particles. An Acad Bras Cienc. 1982 Mar;54(1):233-9. 

Abstract. Using conventional polarographic and spectrophotometric methods, the effect of sodium oleate on isolated mitochondria dn submitochondrial particles was analysed. A loose coupling was developed in isolated mitochondria in the presence of about 10 nmoles oleate per mg protein. Oleate stimulates and activity of bovine heart mitochondrial Mg-ATPase, and it was found to be dependent on substrate concentration. Investigation of the membrane potential showed that the delta psi is abolished at high concentration of oleate. The deterioration of the morphological appearance of mitochondria, occurring on addition of oleate, is also described.