Compendium of the most significant studies with reference to properties, intake, effects.

Niu, F., Haslam, J., Rajewski, R., & Subramaniam, B. (2012). A fluidized-bed coating technology using near-critical carbon dioxide as fluidizing and drying medium. The Journal of Supercritical Fluids, 66, 315-320.

Abstract. A Wurster-type coater employing near-critical carbon dioxide as the fluidizing medium and antisolvent was developed for pharmaceutical applications. Suitably designed glass inserts housed in a high-pressure chamber allow for the controlled fluidization and circulation of the substrates with dense CO2.

Thoennes, C. J., & McCurdy, V. E. (1989). Evaluation of a rapidly disintegrating, moisture resistant lacquer film coating. Drug Development and Industrial Pharmacy, 15(2), 165-185.

Abstract. Simplex optimization was used during the development of a rapidly disintegrating, moisture resistant lacquer film coating. A hygroscopic aniomic exchange resin with the capability of adsorbing four to five times its weight in water was used as the model drug. The coating variables investigated included levels of magenesium stearate, talc, hydroxypropylmethylcelluslose (5 cps), polyethylene glycol 8000, Opaspray, and Eudragit E30D.

Dansereau, R., Brock, M., & Redman-Furey, N. (1993). The solubilization of drug and excipient into a hydroxypropyl methylcellulose (HPMC)-based film coating as a function for the coating parameters in a 24” accela-cota®. Drug development and industrial pharmacy, 19(7), 793-808.

Abstract. In this study, a 23 orthogonal factorial design was used to study the migration of drug and stearic acid from a tablet to an aqueous-based cellulose coating solution. The independent variables evaluated were atomization air pressure, inlet air temperature, and spray rate.

Moyer, S. (1986). 9: Pharmacokinetics of Naproxen Sodium. Cephalalgia, 6(4_suppl), 77-80.