Compendium of the most significant studies with reference to properties, intake, effects.

Solís-Calero C, Ortega-Castro J, Frau J, Muñoz F. Nonenzymatic Reactions above Phospholipid Surfaces of Biological Membranes: Reactivity of Phospholipids and Their Oxidation Derivatives. Oxid Med Cell Longev. 2015;2015:319505. doi: 10.1155/2015/319505.

Abstract. Phospholipids play multiple and essential roles in cells, as components of biological membranes. Although phospholipid bilayers provide the supporting matrix and surface for many enzymatic reactions, their inherent reactivity and possible catalytic role have not been highlighted.

Reis A, Spickett CM. Chemistry of phospholipid oxidation. Biochim Biophys Acta. 2012 Oct;1818(10):2374-87. doi: 10.1016/j.bbamem.2012.02.002. 

Abstract.  This article is part of a Special Issue entitled: Oxidized phospholipids-their properties and interactions with proteins.

Hatch GM. Cell biology of cardiac mitochondrial phospholipids. Biochem Cell Biol. 2004 Feb;82(1):99-112. doi: 10.1139/o03-074.

Abstract. This review will focus on the function and regulation of the biosynthesis and resynthesis of mitochondrial phospholipids in the mammalian heart.

Pakula R, Konikoff FM, Rubin M, Ringel Y, Peled Y, Tietz A, Gilat T. The effects of dietary phospholipids enriched with phosphatidylethanolamine on bile and red cell membrane lipids in humans. Lipids. 1996 Mar;31(3):295-303. doi: 10.1007/BF02529876.

Abstract. The role of phospholipids in biliary cholesterol solubilization and crystallization has only recently begun to be appreciated. Phospholipid vesicles are believed to be the metastable carrier from which cholesterol nucleates. 

Matveyenka M, Rizevsky S, Kurouski D. Unsaturation in the Fatty Acids of Phospholipids Drastically Alters the Structure and Toxicity of Insulin Aggregates Grown in Their Presence. J Phys Chem Lett. 2022 May 17:4563-4569. doi: 10.1021/acs.jpclett.2c00559.

Abstract. Lipid bilayers play an important role in the pathological assembly of amyloidogenic proteins and peptides. This assembly yields oligomers and fibrils, which are highly toxic protein aggregates. In this study, we investigated the role of saturation in fatty acids of two phospholipids that are present in cell membranes. 

Hidalgo FJ, Nogales F, Zamora R. Changes produced in the antioxidative activity of phospholipids as a consequence of their oxidation. J Agric Food Chem. 2005 Feb 9;53(3):659-62. doi: 10.1021/jf0483220.

Abstract. The antioxidative activities of native and oxidized soybean phosphatidylcholine (PC), phosphatidylthanolamine (PE), and phosphatidylinositol (PI) in the protection of soybean oil heated in the dark under air at 60 degrees C were studied in an attempt to clarify the consequences that phospholipid oxidation has on antioxidative activities. 

Cui L, Decker EA. Phospholipids in foods: prooxidants or antioxidants? J Sci Food Agric. 2016 Jan 15;96(1):18-31. doi: 10.1002/jsfa.7320.

Abstract. This review summarizes the fatty acid composition and content of phospholipids naturally occurring in several foods. The role of phospholipids as substrates for lipid oxidation is discussed, with a focus on meats and dairy products. 

Abreu S, Héron S, Solgadi A, Prost B, Dalloux-Chioccioli J, Kermarrec A, Meynier A, Bertrand-Michel J, Tchapla A, Chaminade P. Rapid assessment of fatty acyls chains of phospholipids and plasmalogens by atmospheric pressure chemical ionization in positive mode and high-resolution mass spectrometry using in-source generated monoacylglycerol like fragments intensities. J Chromatogr A. 2022 Apr 27;1673:463093. doi: 10.1016/j.chroma.2022.463093.

Abstract. This study extends the concept to the phospholipids (PLs) category and shows that the APCI+ source can also be used.

Li Z, Luo Z, Shi X, Pang B, Ma Y, Jin J. The Levels of Oxidized Phospholipids in High-Density Lipoprotein During the Course of Sepsis and Their Prognostic Value. Front Immunol. 2022 May 3;13:893929. doi: 10.3389/fimmu.2022.893929. 

Abstract. To examine the levels of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero phosphatidylcholine (POVPC) and 1-palmitoyl-2-glutaroyl-sn-glycero-phosphatidylcholine (PGPC) (the oxidized phosphatidylcholines) in HDL during the course of sepsis and to evaluate their prognostic value.

Sletnes KE. Fosfolipidenes rolle i hemostasen  Role of phospholipids in hemostasis. Tidsskr Nor Laegeforen. 1993 Aug 10;113(18):2238-41.

Abstract. This article reviews the significance of phospholipids in the haemostatic process. The plasma membranes of activated human blood platelets provide a catalytic phospholipid surface on which the "tenase" complex (factor IXa-factor VIIIa) and the "prothrombinase" complex (factor Xa-factor Va) can be assembled. The formation of a procoagulant platelet surface involves the exposure of anionic phospholipids e.g. phosphatidylserine, and is associated with shedding of microvesicles from the membranes of activated platelets. Moreover, tissue-factor, which plays a key role in blood coagulation by initiating the extrinsic coagulation pathway, requires the presence of phospholipids for optimal biological activity. The phospholipid dependency of the coagulation system explains the prolongation of phospholipid dependent clotting tests in patients with phospholipid directed antibodies such as lupus anticoagulants.