Calcium pantothenate  is a chemical compound, calcium salt of vitamin B5 or pantothenic acid, found everywhere in plants and animal tissue.

It appears as a white hygroscopic powder with a bitter taste.  Easily soluble in water, slightly soluble in ethanol. The aqueous solution is slightly alkaline.

What it is used for and where

General biochemical reagent

Medical

Widely used in clinical practice for wound healing, it stimulates epithelial cell growth. A positive effect of Calcium pantothenate on the migration and proliferation of fibroblasts in culture as well as a stimulating effect on the proliferation of dermal fibroblasts has been established (1).

Cosmetics

Moisturising agent, in hair products prevents split ends, increases hair volume and shine.

Hair conditioning agent. A significant number of ingredients with specific and targeted purposes may co-exist in hair shampoo formulations: cleansers, conditioners, thickeners, matting agents, sequestering agents, fragrances, preservatives, special additives. However, the indispensable ingredients are the cleansers and conditioners as they are necessary and sufficient for hair cleansing and manageability. The others act as commercial and non-essential auxiliaries such as: appearance, fragrance, colouring, etc. Hair conditioning agents have the task of increasing shine, manageability and volume, and reducing static electricity, especially after treatments such as colouring, ironing, waving, drying and brushing. They are, in practice, dispersants that may contain cationic surfactants, thickeners, emollients, polymers. The typology of hair conditioning agents includes: intensive conditioners, instant conditioners, thickening conditioners, drying conditioners. They can perform their task generally accompanied by other different ingredients.

Skin conditioning agent - Miscellaneous.  This ingredient has the task of modifying and improving the condition of the skin when it is damaged or dry, reducing flaking and restoring its elasticity.

Food

As a food supplement it promotes the metabolism of carbohydrates and fats, the body's own proteins.

The most relevant studies on this chemical compound have been selected with a summary of their contents:

Calcium pantothenate studies

Typical commercial product characteristics Calcium pantothenate

• Molecular Formula  C₁₈H₃₂CaN₂O₁₀
• Linear Formula    HOCH₂C(CH₃)₂CH(OH)CONHCH₂CH₂CO₂ ·1/2Ca
• Molecular Weight     238.27
• CAS  137-08-6
• UNII    568ET80C3D
• EC Number   205-278-9
• DSSTox Substance ID  DTXSID8040438
• IUPAC  calcium;3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate
• InChI=1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1 
• InChl Key      FAPWYRCQGJNNSJ-UBKPKTQASA-L
• SMILES   CC(C)(CO)C(C(=O)NCCC(=O)[O-])O.CC(C)(CO)C(C(=O)NCCC(=O)[O-])O.[Ca+2]
• MDL number  MFCD00002766
• PubChem Substance ID    24893098
• ChEBI  31345
• Beilstein    3769272
• eCl@ss    34058012
• NACRES NA.21
• RXCUI  1918    
• RTECS   RU4375000
• NCI   C74545

Synonyms

• Calcium D-pantothenate
• D-panthenol
• calcium;3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate
• (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt
• Pantholin

References_____________________________________________________________________

(1) Wiederholt T, Heise R, Skazik C, Marquardt Y, Joussen S, Erdmann K, Schröder H, Merk HF, Baron JM. Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x.