Compendium of the most significant studies with reference to properties, intake, effects.

Farris AL, Rindone AN, Grayson WL. Oxygen Delivering Biomaterials for Tissue Engineering. J Mater Chem B. 2016 May 28;4(20):3422-3432. doi: 10.1039/C5TB02635K. 

Abstract. Tissue engineering (TE) has provided promising strategies for regenerating tissue defects, but few TE approaches have been translated for clinical applications. One major barrier in TE is providing adequate oxygen supply to implanted tissue scaffolds, since oxygen diffusion from surrounding vasculature in vivo is limited to the periphery of the scaffolds. Moreover, oxygen is also an important signaling molecule for controlling stem cell differentiation within TE scaffolds.

Zhang J, Kong C, Yang M, Zang L. Comparison of Calcium Oxide and Calcium Peroxide Pretreatments of Wheat Straw for Improving Biohydrogen Production. ACS Omega. 2020 Apr 16;5(16):9151-9161. doi: 10.1021/acsomega.9b04368.

Abstract. Wheat straw was pretreated with either CaO2 or CaO to improve biohydrogen production. Both CaO and CaO2 pretreatments improved the biodegradability of the wheat straw. 

Sun Y, Lyu S, Brusseau ML, Tang P, Jiang W, Gu M, Li M, Lyu Y, Qiu Z, Sui Q. Degradation of trichloroethylene in aqueous solution by nanoscale calcium peroxide in the Fe(II)-based catalytic environments. Sep Purif Technol. 2019 Nov 1;226:13-21. doi: 10.1016/j.seppur.2019.05.075. 

Abstract. In this study, nCaO2 was synthesized successfully and applied in the Fe(II)-based catalytic environments in investigating trichloroethylene (TCE) removal performance. nCaO2 with the particle sizes in the range of 50-200 nm was prepared, and it performed better for TCE removal when compared to the conventional CaO2.

Mizukami Y, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M. Calcium Peroxide-Containing Polydimethylsiloxane-Based Microwells for Inhibiting Cell Death in Spheroids through Improved Oxygen Supply. Biol Pharm Bull. 2021;44(10):1458-1464. doi: 10.1248/bpb.b21-00269.

Abstract. Multicellular spheroids are expected to be used for in vivo-like tissue models and cell transplantation. Microwell devices are useful for the fabrication of multicellular spheroids to improve productivity and regulate their size. However, the high cell density in microwell devices leads to accelerated cell death. In this study, we developed O2-generating microwells by incorporating calcium peroxide (CaO2) into polydimethylsiloxane (PDMS)-based microwells. 

Curyło K, Telesiński A. Use of Phosphatase and Dehydrogenase Activities in the Assessment of Calcium Peroxide and Citric Acid Effects in Soil Contaminated with Petrol. Open Life Sci. 2020 Feb 28;15:12-20. doi: 10.1515/biol-2020-0002.

Abstract. The objective of the study was to compare the effect of calcium peroxide and citric acid on the activity of acid phosphatase (ACP), alkaline phosphatase (ALP), and dehydrogenases (DHA) in uncontaminated soil and soil contaminated with petrol. 

Park JS, Song YJ, Lim YG, Park K. Facile Fabrication of Oxygen-Releasing Tannylated Calcium Peroxide Nanoparticles. Materials (Basel). 2020 Sep 1;13(17):3864. doi: 10.3390/ma13173864.

Abstract. This study reports a new approach for the facile fabrication of calcium peroxide (CaO2) nanoparticles using tannic acid (TA) as the coordinate bridge between calcium ions. Tannylated-CaO2 (TA/CaO2) nanoparticles were prepared by reacting calcium chloride (CaCl2) with hydrogen peroxide (H2O2) in ethanol containing ammonia and different amounts of TA (10, 25, and 50 mg). The prepared TA/CaO2 aggregates consisted of nanoparticles 25-31 nm in size. The nanoparticles prepared using 10 mg of TA in the precursor solution exhibited the highest efficiency for oxygen generation. Moreover, the oxygen generation from TA (10 mg)/CaO2 nanoparticles was higher in an acidic environment.

Xue Y, Gu X, Lu S, Miao Z, Brusseau ML, Xu M, Fu X, Zhang X, Qiu Z, Sui Q. The destruction of benzene by calcium peroxide activated with Fe(II) in water. Chem Eng J. 2016 Oct 15;302:187-193. doi: 10.1016/j.cej.2016.05.016. 

Abstract. The ability of Fe(II)-activated calcium peroxide (CaO2) to remove benzene is examined with a series of batch experiments. The results showed that benzene concentrations were reduced by 20 to 100% within 30 min. The magnitude of removal was dependent on the CaO2/Fe(II)/Benzene molar ratio, with much greater destruction observed for ratios of 4/4/1 or greater. 

Wu D, Zhu ZQ, Tang HX, Shi ZE, Kang J, Liu Q, Qi J. Efficacy-shaping nanomedicine by loading Calcium Peroxide into Tumor Microenvironment-responsive Nanoparticles for the Antitumor Therapy of Prostate Cancer. Theranostics. 2020 Aug 2;10(21):9808-9829. doi: 10.7150/thno.43631.

Abstract.  we introduce a reactive oxygen species (ROS)-controlled-release nanosystem with TME-responsiveness by applying hollow mesoporous silica nanoparticles (HMSNs) as carriers loaded with calcium peroxide (CaO2) and coated with polyacrylic acid (PAA) to construct the functional material CaO2@HMSNs-PAA. 

Xue Y, Rajic L, Chen L, Lyu S, Alshawabkeh AN. Electrolytic control of hydrogen peroxide release from calcium peroxide in aqueous solution. Electrochem commun. 2018 Aug;93:81-85. doi: 10.1016/j.elecom.2018.06.008. 

Abstract. The in situ generation of hydrogen peroxide (H2O2) for water treatment is more practical than the use of liquid H2O2, which is costly to store and transport. Calcium peroxide (CaO2), a solid carrier of H2O2, can release H2O2 on dissolution in water. 

Massalimov, I.A., Shayakhmetov, A.U. & Mustafin, A.G. Specific features of thermal decomposition of mechanically activated calcium peroxide. Russ J Appl Chem 83, 1794–1798 (2010). https://doi.org/10.1134/S1070427210100113