Ketoprofene is a chemical compound, a bone-monocarboxylic acid consisting of propionic acid.

It occurs as a white crystalline powder 

What it is used for and where

Medical

Ketoprofen has been marketed in France and the UK since 1973. It belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs) and has anti-inflammatory activities and local analgesic properties, for which it is used to combat pain, swelling, arthritis and fever. It is used in mild to moderate musculoskeletal pain and inflammation of muscles and joints, sports injuries and soft tissue rheumatism. Topical application generally minimises adverse effects, while oral ingestion, as with all NSAIDs, has been found to be associated with gastrointestinal disturbances and other systemic adverse events.

Recently, Ketoprofen salified with L-lysine has been marketed, credited in animal studies with better gastric tolerance in vitro, greater solubility 

(Novelli R, Aramini A, Boccella S, Bagnasco M, Cattani F, Ferrari MP, Goisis G, Minnella EM, Allegretti M, Pace V. Ketoprofen lysine salt has a better gastrointestinal and renal tolerability than ketoprofen acid: A comparative tolerability study in the Beagle dog. Biomed Pharmacother. 2022 Jun 27;153:113336. doi: 10.1016/j.biopha.2022.113336. )

Safety

Cases of allergic reactions to ketoprofen have been established (1). 

In this study of 900 children, oral ketoprofen was well tolerated when administered up to 3 weeks after surgery (2).

The results of this study show less harmful effects of ketoprofen than indomethacin on the immature intestine and indicate that the intestinal response to this NSAID varies significantly between individuals (3).

Ketoprofene studies

Appearance	White crystalline powder
Boiling Point	431.3±28.0°C at 760 mmHg
Melting Point	93-96°C
Flash Point	228.8±20.5°C
Density	1.2±0.1 g/cm3
PSA	54.37000
LogP	2.81
Refraction Index	1.592
Vapour Pressure	0.0±1.1 mmHg at 25°C
Safety

• Molecular Formula  C₁₆H₁₄O₃
• Molecular Weight     254.28
• Exact Mass    254.094299
• CAS  22071-15-4
• UNII    90Y4QC304K
• EC Number   244-759-8
• DSSTox Substance ID  DTXSID6020771
• IUPAC  2-(3-benzoylphenyl)propanoic acid
• InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)  
• InChl Key      DKYWVDODHFEZIM-UHFFFAOYSA-N
• SMILES   CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
• MDL number  MFCD00055790
• PubChem Substance ID    57654315
• ChEBI  6128
• NACRES NA.77  
• NSC   758144
• RTECS   UE7570000

Synonyms

Alrheumum, Aneol, Capisten, Epatec, Orudis, Profenid, Dexal, Keduril, Ketosolan, Kevadon, Oruvail, 3-Benzoyl-alpha-methylbenzeneacetic acid, 2-(3-Benzoylphenyl)propionic acid, 2-(m-Benzoylphenyl)propionic acid, 3-Benzoylhydratropic acid,  Benzeneacetic acid, 3-benzoyl-alpha-methyl, m-benzoylhydratropic acid

References___________________________________________________________________

(1) Cantisani C, Grieco T, Faina V, Mattozzi C, Bohnenberger H, Silvestri E, Calvieri S. Ketoprofen allergic reactions. Recent Pat Inflamm Allergy Drug Discov. 2010 Jan;4(1):58-64. doi: 10.2174/187221310789895595.

(2) Kokki H. Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients. Paediatr Drugs. 2010 Oct 1;12(5):313-29. doi: 10.2165/11534910-000000000-00000.

(3) Thibault MP, Tremblay É, Wallace JL, Beaulieu JF. Effect of Ketoprofen and ATB-352 on the Immature Human Intestine: Identification of Responders and Non-responders. J Pediatr Gastroenterol Nutr. 2019 May;68(5):623-629. doi: 10.1097/MPG.0000000000002308.