Ketoprofene sale di lisina  is a chemical compound, ketoprofen salinised with L-lysine.

It appears as a white crystalline powder.

Ketoprofen salified with L-lysine has recently been placed on the market, credited by various studies with improved gastric tolerance in vitro, greater solubility (Novelli R, Aramini A, Boccella S, Bagnasco M, Cattani F, Ferrari MP, Goisis G, Minnella EM, Allegretti M, Pace V. Ketoprofen lysine salt has a better gastrointestinal and renal tolerability than ketoprofen acid: A comparative tolerability study in the Beagle dog. Biomed Pharmacother. 2022 Jun 27;153:113336. doi: 10.1016/j.biopha.2022.113336).

Ketoprofene is a chemical compound, a bone-monocarboxylic acid consisting of propionic acid.

What it is used for and where

Medical

Take only under medical supervision

Ketoprofen has been marketed in France and England since 1973. It belongs to the family of non-steroidal anti-inflammatory drugs (NSAIDs) and has anti-inflammatory activities and local analgesic properties, for which it is used to combat pain, swelling, arthritis and fever. It is used in mild to moderate musculoskeletal pain and inflammation of muscles and joints, sports injuries and soft tissue rheumatism. Topical application generally minimises adverse effects, while oral ingestion, as with all NSAIDs, has been found to be associated with gastrointestinal disturbances and other systemic adverse events.

Safety

Cases of allergic reactions to ketoprofen have been reported (1). 

In this study of 900 children, oral ketoprofen was well tolerated when administered up to 3 weeks after surgery (2).

The results of this study show less harmful effects of ketoprofen than indomethacin on the immature intestine and indicate that the intestinal response to this NSAID varies significantly between individuals (3).

Like all drugs it can cause side effects. Always ask the physician.

Ketoprofen lysinate studies

Typical commercial product characteristics Ketoprofen lysinate

Appearance	White crystalline powder
Boiling Point	431.3±28.0°C at 760 mmHg
Melting Point	N/A
Flash Point	228.8±20.5°C
Density	1.198g/cm3
PSA	143.71000
LogP	4.03360
Safety

• Molecular Formula   C₂₂H₂₈N₂O₅
• Molecular Weight     400.5
• Exact Mass    400.20000
• CAS  57469-78-0
• UNII    5WD00E3D4C
• EC Number   643-003-8
• DSSTox Substance ID  DTXSID40972999
• IUPAC  2-(3-benzoylphenyl)propanoic acid;(2S)-2,6-diaminohexanoic acid
• InChI=1S/C16H14O3.C6H14N2O2/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12;7-4-2-1-3-5(8)6(9)10/h2-11H,1H3,(H,18,19);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1
• InChl Key      VHIORVCHBUEWEP-ZSCHJXSPSA-N
• SMILES   CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O.C(CCN)CC(C(=O)O)N

Synonyms

ketoprofen lysine salt, Lysyl-ketoprofen, ketoprofen lysine

References___________________________________________________________________

(1) Cantisani C, Grieco T, Faina V, Mattozzi C, Bohnenberger H, Silvestri E, Calvieri S. Ketoprofen allergic reactions. Recent Pat Inflamm Allergy Drug Discov. 2010 Jan;4(1):58-64. doi: 10.2174/187221310789895595.

(2) Kokki H. Ketoprofen pharmacokinetics, efficacy, and tolerability in pediatric patients. Paediatr Drugs. 2010 Oct 1;12(5):313-29. doi: 10.2165/11534910-000000000-00000.

(3) Thibault MP, Tremblay É, Wallace JL, Beaulieu JF. Effect of Ketoprofen and ATB-352 on the Immature Human Intestine: Identification of Responders and Non-responders. J Pediatr Gastroenterol Nutr. 2019 May;68(5):623-629. doi: 10.1097/MPG.0000000000002308.