Econazole is a chemical compound, derived from imidazole, synthesised in 1969 and placed on the commercial market in the 1970s.

It appears in the form of a white powder with low solubility in water.

What it is used for and where

Medical

For systemic use, econazole is administered in basic oral or intravenous form, while for local applications the nitrate salt of econazole is used.

An antifungal agent that has shown a broad spectrum of activity against Candida albicans, Aspergillus and Staphylococcus, commonly used in the form of econazole nitrate for the treatment of general fungal infections, fungal infections of the skin, such as 

• the dermatophytic infection of athlete's foot (Tinea pedis) localised in the interdigital spaces of the toes, caused by the fungi Trichophyton rubrum, Epidermophyton floccosum, Trichophyton mentagrophytes  
• tinea versicolor or pityriasis versicolor (mycosis) caused by the mycete Malassezia furfur, ringworm, 
• sock itch 

and other infections caused by certain Gram-positive bacteria, filamentous fungi (Rhizopus spp), yeasts and moulds.

This study analysed the properties of Econazole in laboratory animals, found that Econazole significantly suppressed the growth of lung cancer cells and concluded that Econazole could be used in the treatment of lung cancer alone or in combination with cisplatin (1).

Econazole studies

Appearance	White powder
Boiling Point	533.8±50.0°C at 760 mmHg
Melting Point	86.8ºC
Density	1.3±0.1 g/cm3
Flash Point	276.6±30.1°C
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refraction Index	1.615
PSA	27.05000
LogP	5.32
Safety

Price

SKU   Y0001236    €117.00

• Molecular Formula      C₁₈H₁₅Cl₃N₂O
• Molecular Weight     381.7
• Exact Mass     380.024994
• CAS  27220-47-9
• UNII    6Z1Y2V4A7M
• EC Number   248-341-6
• DSSTox Substance ID  DTXSID2029872
• IUPAC  1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
• InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2  
• InChl Key      LEZWWPYKPKIXLL-UHFFFAOYSA-N
• SMILES   C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
• MDL number  
• PubChem Substance ID    
• ChEBI  82873
• NACRES    NA.24
• NSC   187789
• RTECS   NI4767000

Synonyms

1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-

References_______________________________________________________________________

(1) Dong C, Yang R, Li H, Ke K, Luo C, Yang F, Shi XN, Zhu Y, Liu X, Wong MH, Lin G, Wang X, Leung KS, Kung HF, Chen C, Lin MC. Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells. Sci Rep. 2017 Dec 21;7(1):17987. doi: 10.1038/s41598-017-18178-0.