Caprylyl/Capryl Glucoside  is a natural substance of plant origin obtained industrially by a chemical process from the condensation of a mixture of high-carbon caprylic and decyl alcohols with glucose.

It appears as a white to pale yellow odourless gel-cream liquid. 

What it is used for and where

Cosmetics

Surfactant with excellent solubilising properties in highly concentrated surfactant solutions even in the presence of salt and alkalis.

Cleansing agent, PEG-free. It has an anti-ageing, anti-oxidant and skin-protective action thanks to the release of vitamin C, which can also promote the synthesis of collagen (an important protein in skin structure and firmness), effectively inhibit melanin and exert a light discolouring and lightening action on the skin. These effects depend on the doses included in the cosmetic formula and any penetrating agents. In general, it is a surfactant that is rather gentle on the skin.

Surfactant - Cleansing agent. Cosmetic products used to cleanse the skin utilise the surface-active action that produces a lowering of the surface tension of the stratum corneum, facilitating the removal of dirt and impurities. 

Foaming.  Its function is to introduce gas bubbles into the water for a purely aesthetic factor, which does not affect the cleaning process, but only satisfies the commercial aspect of the detergent by helping to spread the detergent. This helps in the commercial success of a cleansing formulation. Since sebum has an inhibiting action on the bubble, more foam is produced in the second shampoo.

Cleansing agent. Ingredient that cleanses skin without exploiting the surface-active properties that produce a lowering of the surface tension of the stratum corneum. 

Medical

Caprylyl/Capryl Glucoside, non-ionic polyhydroxy surfactant with a stabilising function, can be used as an effective topical formulation for the healing of corneal epithelial wounds as treatment has shown significant improvement in epithelial healing (1). Epithelial absorption as an average absorbed dose of caprylyl/capryl glucoside is typically 0.01% (2).

Safety

Alkyl glucosides are supplied to cosmetic companies at an active ingredient concentration of less than 100% and are safe in current use and concentration practices if they are formulated to be non-irritant (3).

Use: 1% to 2% fragrance/essential oil without the need for a solubiliser.

For more details:

Caprylyl/Capryl Glucoside studies

Caratteristiche tipiche del prodotto commerciale Caprylyl Capryl Glucoside

Price

0,5 l          $14.00

1 l             $21.50

20 l          $337.00

• Molecular Formula      C₁₂H₁₈O₁₁     
• Molecular Weight      338.265
• Exact Mass     338.084900
• CAS       68515-73-1    129499-78-1 
• UNII    2V52R0NHXW
• EC Number   253-874-2
• DSSTox Substance ID  DTXSID50926423
• IUPAC  (2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2H-furan-5-one
• InChl=1S/C12H18O11/c13-1-3(15)9-8(19)10(11(20)22-9)23-12-7(18)6(17)5(16)4(2-14)21-12/h3-7,9,12-19H,1-2H2/t3-,4+,5+,6-,7+,9+,12+/m0/s1
• InChl Key      MLSJBGYKDYSOAE-DCWMUDTNSA-N
• SMILES   C(C1C(C(C(C(O1)OC2=C(C(OC2=O)C(CO)O)O)O)O)O)O
• MDL number  MFCD23701380
• PubChem Substance ID    329822597
• ChEBI  81685
• RXCUI      1306933
• NACRES NA.24  
• HS Code    2936270090

Synonyms

• Ascorbyl glucoside
• 2-O-α-D-Glucopyranosyl-L-ascorbic Acid

References_____________________________________________________________________

(1) Jaber M, Jaber B, Hamed S, AlKhatib HS. Preparation and evaluation of ascorbyl glucoside and ascorbic acid solid in oil nanodispersions for corneal epithelial wound healing. Int J Pharm. 2022 Nov 5;627:122227. doi: 10.1016/j.ijpharm.2022.122227.

(2) Across Barriers GmbH. In vitro permeation and penetration of capryl glucoside (inci: caprylyl/capryl glucoside) from the product Plantacare 810 UP in human skin under GLP conditions. GLP Study Report STP 044/00. Science Park 1; 661 23 Saarbruecken; Germany, Across Barriers GmbH; 2009. Report no. C-10335-244-1 107.

(3) Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... & Andersen, F. A. (2013). Safety assessment of decyl glucoside and other alkyl glucosides as used in cosmetics. International Journal of Toxicology, 32(5_suppl), 22S-48S.