Compendium of the most significant studies with reference to properties, intake, effects.

Ullah F, Ayaz M, Sadiq A, Hussain A, Ahmad S, Imran M, Zeb A. Phenolic, flavonoid contents, anticholinesterase and antioxidant evaluation of Iris germanica var; florentina. Nat Prod Res. 2016 Jun;30(12):1440-4. doi: 10.1080/14786419.2015.1057585. 

Abstract. This study was designed to investigate antioxidant and anticholinesterase potential of Iris germanica var; florentina. Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potential of plant samples were investigated by Ellman's assay. Antioxidant activity was performed using DPPH, H2O2 and ABTS free radical scavenging assays. Total phenolics and flavonoids contents were expressed in mg GAE/g dry weight and mg RTE/g, respectively. In AChE inhibition assay, Ig.Fl, Ig.Sp and Ig.Cf fractions exhibited highest activity with IC50 values of < 0.1, 5.64 and 19 μg/mL, respectively. In BChE inhibitory assay, Ig.Fl, Ig.Sp, Ig.Cf and Ig.Cr were most active with IC50 of < 0.1, < 0.1, 31 and 78 μg/mL, respectively. In DPPH assay, Ig.Fl and Ig.Cf exhibited highest inhibition of free radicals, 80.52% (IC50 = 9 μg/mL) and 78.30% (IC50 = 8 μg/mL), respectively. In ABTS assay Ig.Cr, Ig.Cf, Ig.Fl and Ig.Sp exhibited IC50 values of < 0.1, 2, 2 and 3 μg/mL, respectively.

Kazandjieva J, Dimitrova J, Sankeva M, Yankov D, Bocheva V, Kircheva K, Gincheva V, Gospodinova K, Andasorova R, Milanova M, Jeleva D, Zlateva P, Vasileva I, Yankova R, Gotseva S, Dakova T, Zografova E, Marina S, Kateva M, Broshtilova V, Todeva V, Tsankov N, Mitova Z, Boyanova N, Milani M. Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women. J Cosmet Dermatol. 2022 May 12. doi: 10.1111/jocd.15074. 

Abstract. Background: Adult female acne (AFA) nowadays is a very common skin condition affecting mainly women aged between 25 and 40. The treatment of AFA could be challenging. Study aim: We evaluate and compare the efficacy and tolerability of a cream formulation containing two retinoid molecules (hydroxypinacolone/retinyl palmitate) combined with Iris Florentina root extract and a complex of three oligopeptides (C) applied twice a day (morning and evening) alone or in combination (C + O) with a food supplement containing a mixture of prebiotic molecules (FOS&GOS) zinc, lactoferrin, and niacinamide....Conclusion: A cream containing retinoid molecules and Iris Florentina root extract is effective and well tolerated in the management of AFA. The treatment combination with a prebiotic and anti-inflammatory food supplement offers an additional clinical benefit mainly in reducing inflammatory lesions and improving the severity acne score. © 2022 Wiley Periodicals LLC.

Crişan, I., & Cantor, M. (2016). New perspectives on medicinal properties and uses of Iris sp. Hop Med Plants, 24, 24-36.

Abstract. The role of medicinal and aromatic plants in prophylactic and curative medicine is long known, being increasingly appreciated worldwide and in our country. Man used natural resources in the middle of which he lived, from the beginning of its existence. He found in the vegetal and animal world the livelihood, food, clothes and solutions to remedy the organic suffering. Gradually, he managed to identify plants that were beneficial to his health, for healing wounds and curing various diseases. From traditional medicine to modern medicine, the practice of healing human suffering could not part with medicinal plants, which are an invaluable pool of active principles, bundled into the immensity of flowers, leaves, roots etc. Human civilizations that have succeeded each brought their contribution to the knowledge and use of a growing number of medicinal plants. Many scholars of ancient times until nowadays have also recorded in their writings the medicinal qualities and the proper way of use of many plants. At the same time with the development of chemistry it also became possible the knowledge of active substances (active principles) in plants. Until a century ago, about three quarters of pharmaceutical preparations were made from vegetable products, then synthetic medicines have come to hold more weight and medicinal plants were considered by some ʺtherapeutic fossilsʺ. The interest in therapy with pharmaceutical products derived from plants is growing steadily from the second half of the last century, due to the fact that they are more compatible with the human body, being closer in metabolic terms and more easily tolerated than synthetic medicines. Current medical trends are grafted increasingly on the use of phytotherapy (treatment with pharmaceutical products derived from plants), limiting the explosive use of synthetic drugs to the strictly necessary. Phytotherapy is a real possibility in modern therapeutics alongside chemotherapy, physiotherapy and balneology, electrotherapy, food hygiene etc. 

Fujita, M., & INOUE, T. (1982). Studies on the constituents of Iris florentina L. II. C-glucosides of xanthones and flavones from the leaves. Chemical and Pharmaceutical Bulletin, 30(7), 2342-2348.

Abstract. Four C-glucosylxanthones [Mangiferin (3), isomangiferin (2), 4 and 5] and three C-glucosylflavones [swertisin (6), isoswertisin (7) and isoswertiajaponin (8)] were isolated from the fresh leaves of Iris florentina L. (Iridaceae). The structures of 4 and 5 were shown to be 7-O-methylmangiferin and 7-O-methylisomangiferin, respectively, by chemical and spectroscopic methods. In addition, the 13C nuclear magnetic resonance chemical shifts of aryl carbons in these C-glucosylxanthones (2-5) were assigned. On the basis of the co-occurrence of several types of xanthone and flavone C-glucosides, the biosynthetic relationship between both C-glucosides is briefly discussed.