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 | "Descrizione" by FCS777 (5566 pt) | 2022-Nov-16 10:03 |
| Evaluation | N. Experts | Evaluation | N. Experts |
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| 1 | 6 | ||
| 2 | 7 | ||
| 3 | 8 | ||
| 4 | 9 | ||
| 5 | 10 |
Paeonia lactiflora (Pallas 1776) or Peony, is a shrub, a perennial herbaceous species, and an important ornamental plant belonging to the Paeoniaceae family that flowers with large, intensely coloured flowers.
An extract of the root is obtained from Paeonia lactiflora.
It appears in the form of a brown powder.
What it is used for and where
Medical
Paeonia lactiflora root extract has a long history in traditional medical science of anti-inflammatory and pain-relieving effects in the treatment of gynaecological disorders, particularly in Chinese medicine (1). The pharmacological mechanisms behind the anti-inflammatory immune-regulating activity lie largely in the main active component of this herbaceous species called Pae and its compounds, a monomer. Pae is present in the root to an extent approaching 40 per cent, thus to a significant extent. Pae is able to decrease bone erosion, pain, joint swelling, synovial hypertrophy. cartilage degradation in experimental arthritis (2) and rheumatoid arthritis (3).
Methyl gallate present in the root and leaves of Paeonia lactiflora appears to be the component that has a strong inhibitory effect against premature atherosclerosis (4) and could be of some importance as a nutraceutical component.
Cosmetics
Certain components of Paeonia lactiflora (paeoniflorin, galloylpaeoniflorin, benzoylpaeoniflorin their derivatives and Pae derivatives, a monomer) have been shown in clinical studies to reduce the effects of melanin formation by improving the stratum corneum of the skin (5). The root extract enhanced the expression of skin barrier genes and also improved their function (6).
The most relevant studies and their abstracts have been selected to explore this in more depth:
Typical commercial product characteristics Paeonia Lactiflora Root Extract
| Appearance | Light yellow Brown Powder |
| Mesh size | 80 Mesh |
| Active ingredients | Paeoniflorin (10%,50% ) |
| Loss on drying | ≤5.0% |
| Ash | ≤5.0% |
| Pb | ≤2.0 ppm |
| As | ≤2.0 ppm |
| Cd | ≤2.0 ppm |
| Hg | ≤0.5 ppm |
| Total Plate | ≤1.000 cfu/g |
| Yeast & Mold | ≤100 cfu/g |
| Shelf Time | 2 years |
References_____________________________________________________________________
(1) Schramm, G. (1955). Pharmacopeia of the People's Republic of China. Pharmazeutische Zentralhalle fur Deutschland, 94(5), 173-175.
(2) Zhang, L. L., Wei, W., Wang, N. P., Wang, Q. T., Chen, J. Y., Chen, Y., ... & Hu, X. Y. (2008). Paeoniflorin suppresses inflammatory mediator production and regulates G protein-coupled signaling in fibroblast–like synoviocytes of collagen induced arthritic rats. Inflammation Research, 57(8), 388-395.
(3) Li Q, Hu S, Huang L, Zhang J, Cao G. Evaluating the Therapeutic Mechanisms of Selected Active Compounds in Cornus Officinalis and Paeonia Lactiflora in Rheumatoid Arthritis via Network Pharmacology Analysis. Front Pharmacol. 2021 Apr 21;12:648037. doi: 10.3389/fphar.2021.648037.
(4) Kim MJ, Kang HH, Seo YJ, Kim KM, Kim YJ, Jung SK. Paeonia lactiflora Root Extract and Its Components Reduce Biomarkers of Early Atherosclerosis via Anti-Inflammatory and Antioxidant Effects In Vitro and In Vivo. Antioxidants (Basel). 2021 Sep 23;10(10):1507. doi: 10.3390/antiox10101507.
(5) Liu X, Chen Y, Zhang J, He Y, Ya H, Gao K, Yang H, Xie W, Li L. Widely targeted metabolomics reveals stamen petaloid tissue of Paeonia lactiflora Pall. being a potential pharmacological resource. PLoS One. 2022 Sep 2;17(9):e0274013. doi: 10.1371/journal.pone.0274013.
(6) Kim KH, Shim JS, Kim HJ, Son ED. Penta-O-galloyl-β-D-glucose from Paeonia lactiflora Pall. root extract enhances the expression of skin barrier genes via EGR3. J Ethnopharmacol. 2020 Feb 10;248:112337. doi: 10.1016/j.jep.2019.112337.
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