Caffeine is a natural alkaloid that acts as a stimulant of the central nervous system. In particular it is absorbed by the stomach and in about half an hour enters the cardiovascular system. It is me ...

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Caffeine is a natural alkaloid that acts as a stimulant of the central nervous system.

In particular it is absorbed by the stomach and in about half an hour enters the cardiovascular system. It is metabolized by the liver and expelled through the kidneys.

In the meantime it installs itself in the cerebral cortex and in the brain stem where it creates a state of attention and / or restlessness.

High doses of caffeine, product intolerance or drug use can have serious consequences on the body (1).

It can be addictive.

The high and increasing consumption of so-called energy drinks over the last few years is taken into consideration by this in-depth study on 2097 publications and the relationship between caffeine (present in such beverages) and adverse events in the cardiovascular and neurological system is discussed (2 ) and here the negative effects of these drinks are analyzed (3).

Caffeine is used in the following products:

• cosmetics
• personal care products
• perfumes and fragrances

It is likely that there will be emissions of this substance into the environment from:

• washing liquids
• machine detergents
• car care products
• paints
• coatings or adhesives
• fragrances and deodorants

Caffeine studies

Molecular Formula: C₈H₁₀N₄O₂

Molecular Weight: 194.194 g/mol

UNII: 3G6A5W338E

CAS: 58-08-2  71701-02-5  95789-13-2

EC Number: 200-362-1

FEMA Number: 2224

PubChem Substance ID 24277682

MDL number MFCD00005758

Beilstein Registry Number 17705

Synonyms:

• 1,3,7-Trimethylpurine-2,6-dione
• Theobromine, 1-methyl-
• Propoxyphene Compound 65
• SK-65 Compound
• teina
• Ercatab
• Lanorinal
• 1,3,7-trimethyl-1,3,7-trihydropurine-2,6-dione
• 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
• 1,3,7-trimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine
• 1-methyltheobromine
• 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
• 1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
• 1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione
• 1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• Theophylline Me
• Xanthine, 1,3,7-trimethyl
• Methylxanthine theophylline
• Theobromine Me
• Phensal
• 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
• Caffeine, synthetic
• Quick-Pep
• Durvitan
• Wigraine
• 1,3,7-Trimethyl-2,6-dioxopurine
• Theophylline, 7-methyl
• DHCplus
• Tri-Aqua
• Kofein
• Miudol
• Caffeine, anhydrous
• Tirend
• Cafecon
• Caffine
• Dexitac
• Nodaca
• Caffedrine
• Stim
• Methyltheobromine
• Koffein
• Mateina
• Theine
• Alert-pep

 

References________________________________________

(1) Survival of a highly toxic dose of caffeine.
Bioh G, Gallagher MM, Prasad U.
BMJ Case Rep. 2013 Feb 8;2013. pii: bcr2012007454. doi: 10.1136/bcr-2012-007454.

A case of caffeine-induced coronary artery vasospasm of a 17-year-old male.
Wilson RE, Kado HS, Samson R, Miller AB.
Cardiovasc Toxicol. 2012 Jun;12(2):175-9. doi: 10.1007/s12012-011-9152-9.

A case of atrial tachycardia sensitive to increased caffeine intake.
Kinugawa T, Kurita T, Nohara R, Smith ML.
Int Heart J. 2011;52(6):398-400.

(2) Energy drinks and their adverse health effects: a systematic review of the current evidence.
Ali F, Rehman H, Babayan Z, Stapleton D, Joshi DD.
Postgrad Med. 2015 Jan 6:1-15.

Consumption of energy drinks with alcohol, hazardous mixture.
Iglesias-Lepine ML, Epelde F, Espinosa J, Mariñosa M.
Med Clin (Barc). 2013 Aug 4;141(3):135-6. doi: 10.1016/j.medcli.2012.11.009. 

(3) Risks of energy drinks in youths.  Bigard AX
Arch Pediatr. 2010 Nov;17(11):1625-31. doi: 10.1016/j.arcped.2010.08.001.

 

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