Triazolam is a chemical compound, a benzodiazepine, a sedative-hypnotic drug generally prescribed for the treatment of insomnia that came onto the market in 1983 in the USA and has since been authorised in 90 countries.

What it is for and where

Medical

Take only under medical supervision

The mechanism of this drug acts on the receptor that mediates sleep (BNZ1) and on another receptor that controls different important physiological functions such as memory, muscle relaxation, and motor coordination (BNZ2).  Its half-life, i.e. the time it takes for 50% of the substance to decay, is rather short, 2 to 3 hours in healthy adults. This means that the sedative-hypnotic effect loses its effectiveness 24 hours after intake.

In England it was withdrawn from the market because of the risk of psychiatric adverse drug reactions, particularly amnesia, while it continues to be available in the United States (1). France and Italy banned 0.5mg packs in 1987, as did Germany in 1988. In 1988 the US Food and Drug Administration (FDA) approved the 0.25 packet for healthy adults and the 0.125 mg packet (for the elderly or debilitated).

Like all drugs it can cause side effects. Always ask the physician.

Triazolam  studies

Melting Point	209-212°C
Flash Point	11°C
PSA	43.07000
LogP	3.66910
Storage	2-8°C
Chemical Safety

Molecular Formula      C₁₇H₁₂Cl₂N₄

Molecular Weight      343.2

Exact Mass   342.04400

CAS  28911-01-5

UNII    1HM943223R

EC Number   249-307-3

DSSTox ID  DTXSID6046763

IUPAC  8-cloro-6-(2-clorofenil)-1-metil-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepina

InChl=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3

InChl Key      JOFWLTCLBGQGBO-UHFFFAOYSA-N

SMILES  CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4Cl

NACRES  NA.24

PubChem Substance ID    

ChEBI  9674

RTECS  XZ5472500

NCI    C29520

Synonyms:

• Songar
• Halcion
• Clorazolam
• Novidorm

References_____________________________________________________________________

(1) http://www.t3db.ca/toxins/T3D2564

https://www.latimes.com/archives/la-xpm-1991-10-03-mn-4409-story.html#:~:text=The%20British%20government%20on%20Wednesday,the%20Department%20of%20Health%20said.