Lactobacillus Ferment Lysate is a product derived from the bacterium Lactobacillus fermentation, a diversified group comprising many species used in food, cosmetics and medicine.

The name describes the structure of the molecule

• "Lactobacillus" refers to a genus of beneficial bacteria, often used in the fermentation of dairy products like yogurt.
• "Ferment" indicates that the product is derived from a fermentation process using the Lactobacillus bacterium.

Description of raw materials used in production

• Lactobacillus Strain - A specific species or subspecies of Lactobacillus bacteria.
• Culture Medium - Nutrients required for the growth and proliferation of the bacterium.

Step-by-step summary of industrial chemical synthesis process

• Medium Preparation - The culture medium is prepared with all the necessary nutrients for Lactobacillus growth.
• Inoculation - The Lactobacillus strain is introduced into the prepared medium.
• Fermentation - The inoculated medium is incubated under controlled conditions to allow for bacterial growth and fermentation.
• Harvest - After a certain period, the fermentation product containing metabolites and cellular components of Lactobacillus is harvested.
• Purification - Any impurities or undesired components are removed through various purification processes.

Form and Color

What it is for and where

Medical

The genus lactobacillus is an important defense factor of the human gastrointestinal, oral and vaginal microbiota by preventing the growth of pathogens (1).

Cosmetics

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

Commercial applications

Cosmetics. Used in skincare products for its skin conditioning and antimicrobial properties.

Probiotic Beauty Products. Lactobacillus Ferment is often incorporated into probiotic cosmetics aiming to balance the skin's microflora.

Natural Preservatives. Utilized as an alternative to synthetic preservatives in personal care products.

Medical Applications

Skincare Products. Incorporated into formulations to soothe irritated skin and reduce inflammation (2).

Research. Explored for its potential benefits in treating skin conditions and balancing the skin's microflora.

Probiotics. Employed in supplements to support gut microbiome health.

References_____________________________________________________________________

(1) Bautista CT, Wurapa E, Sateren WB, Morris S, Hollingsworth B, Sanchez JL. Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections. Mil Med Res. 2016 Feb 13;3:4. doi: 10.1186/s40779-016-0074-5. 

Abstract. Bacterial vaginosis (BV) is a common vaginal disorder in women of reproductive age. Since the initial work of Leopoldo in 1953 and Gardner and Dukes in 1955, researchers have not been able to identify the causative etiologic agent of BV. There is increasing evidence, however, that BV occurs when Lactobacillus spp., the predominant species in healthy vaginal flora, are replaced by anaerobic bacteria, such as Gardenella vaginalis, Mobiluncus curtisii, M. mulieris, other anaerobic bacteria and/or Mycoplasma hominis. Worldwide, it estimated that 20–30 % of women of reproductive age attending sexually transmitted infection (STI) clinics suffer from BV, and that its prevalence can be as high as 50–60 % in high-risk populations (e.g., those who practice commercial sex work (CSW). Epidemiological data show that women are more likely to report BV if they: 1) have had a higher number of lifetime sexual partners; 2) are unmarried; 3) have engaged in their first intercourse at a younger age; 4) have engaged in CSW, and 5) practice regular douching. In the past decade, several studies have provided evidence on the contribution of sexual activity to BV. However, it is difficult to state that BV is a STI without being able to identify the etiologic agent. BV has also emerged as a public health problem due to its association with other STIs, including: human immunodeficiency virus (HIV), herpes simplex virus type 2 (HSV-2), Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). The most recent evidence on the association between BV and CT/NG infection comes from two secondary analyses of cohort data conducted among women attending STI clinics. Based on these studies, women with BV had a 1.8 and 1.9-fold increased risk for NG and CT infection, respectively. Taken together, BV is likely a risk factor or at least an important contributor to subsequent NG or CT infection in high-risk women. Additional research is required to determine whether this association is also present in other low-risk sexually active populations, such as among women in the US military. It is essential to conduct large scale cross-sectional or population-based case-control studies to investigate the role of BV as a risk factor for CT/NG infections. These studies could lead to the development of interventions aimed at reducing the burden associated with bacterial STIs worldwide.

(2) Tsai WH, Chou CH, Chiang YJ, Lin CG, Lee CH. Regulatory effects of Lactobacillus plantarum-GMNL6 on human skin health by improving skin microbiome. Int J Med Sci. 2021 Jan 1;18(5):1114-1120. doi: 10.7150/ijms.51545.

Abstract. Bacteria response to their environment by producing some compounds which are used in cosmetic and pharmaceutical applications. Some probiotics can regulate immune response and modulate the symptoms of several diseases. Bacteria affect skin response to skin care products. Bacteria are thought to play an important role in acne incidence, skin moisture, and nutrient metabolism, but only a few studies have focused on the extracts of Lactobacillus plantarum in skin care. In this study, we identified that L. plantarum-GMNL6 enhanced collagen synthesis and the gene expression of serine palmitoyltransferase small subunit A. Meanwhile, L. plantarum-GMNL6 reduced the melanin synthesis, the biofilm of Staphylococcus aureus, and the proliferation of Cutibacterium acnes. Information from clinical observation during the ointment for external face use in people displayed that the syndromes of skin moisture, skin color, spots, wrinkles, UV spots, and porphyrins were improved. The diversification of human skin microbiomes was affected by smearing the face of volunteers with L. plantarum-GMNL6. Understanding the potential mechanisms of the action of L. plantarum-GMNL6 in dermatologic conditions promotes the development of care products.