Take only under medical supervision

Sodium fusidate is a chemical compound, salt of fusidic acid.

The name describes the structure of the molecule:

• Sodium refers to the sodium ion, which is an alkali metal found in nature. It is often used in medicine and cosmetics to form salts with other compounds.
• Fusidate is derived from "Fusidium", the genus of fungi from which fusidic acid, the main component of sodium fusidate, was originally isolated.

Function. Sodium fusidate is a steroidal antibiotic (1) used to treat bacterial skin infections (2). It has specific action against the bacterium Staphylococcus aureus, including MRSA (Methicillin-resistant Staphylococcus aureus).

Raw Materials Used in Production:

• Sodium fusidate is derived from the fermentation of the fungus Fusidium coccineum.

Step-by-step Summary of Industrial Production Process.

• Fermentation. Fusidium coccineum is cultivated under controlled conditions to produce fusidic acid.
• Extraction. The fusidic acid is extracted from the fermentation through various methods, including the use of organic solvents.
• Conversion. The fusidic acid is then converted to sodium fusidate by adding a sodium hydroxide solution.
• Purification. Sodium fusidate is purified from impurities through processes such as crystallization.

Form and Color.

Sodium fusidate appears as a white or almost white crystalline powder.

Like all drugs it can cause side effects. Always ask the physician.

• Molecular Formula    C₃₁H₄₇NaO₆
• Molecular Weight  538.7 g/mol
• CAS  751-94-0
• UNII    J7P3696BCQ
• EC Number   212-030-3
• DTXSID9045552

References_____________________________________________________________________

(1) Holmbäck J, Rinwa V, Johansson J, Håkansson J, Rinwa P, Carlsson A, Herslöf B. Preclinical development of sodium fusidate antibiotic cutaneous spray based on water-free lipid formulation system. Eur J Pharm Sci. 2022 Sep 1;176:106250. doi: 10.1016/j.ejps.2022.106250. 

(2) Rajapakse RDN, Weerasekara TA, Wijayaratne WGB, Nandasiri GK. Microencapsulated sodium fusidate to impart antibacterial properties into cotton dressings for traumatic wounds. J Wound Care. 2022 Jan 2;31(1):99-109. doi: 10.12968/jowc.2022.31.1.99. PMID: 35077219.

Abstract. This research aimed to investigate the use of microencapsulated sodium fusidate to impart antibacterial properties into conventional cotton gauze used to treat traumatic wounds. The microcapsules were prepared with sodium fusidate dissolved in ethanol as the active substance (core) and calcium alginate as the wall material (shell) using an electrospraying method. The microcapsules were then loaded into a 1% solution of chitosan, and conventional sterile cotton gauze fabric was impregnated in this suspension and dried at room temperature. The microcapsules obtained were examined with Fourier transform infrared spectroscopy to confirm the constituents, and by scanning electron microscopy to examine the size and distribution of the microcapsules. The results showed that microcapsules with sodium fusidate as the core material were produced in a size range of 50-200µm. The antibacterial properties of these gauze samples were tested for resistance to both Gram-positive and Gram-negative bacteria. The samples showed antibacterial properties against Gram-positive bacteria (Staphylococcus aureus) only, with an average inhibition zone of 31.67±2.89mm in diameter. The antibacterial effect of the treated gauze samples was tested after washing to investigate the strength of the binding agent, to find out whether the samples maintained antibacterial properties after two hand-rubbed washes. Its absorption capacity, rate of absorbency and air permeability values were 555±4.51%, 1.25±0.04 seconds and 408±2.65cm3/cm2/seconds, respectively. The research findings have established the possibility of imparting antibacterial properties into sterile cotton gauze using microencapsulation of sodium fusidate.