Mimosa Tenuiflora Bark Extract is a naturally occurring compound derived from the bark of the Mimosa Tenuiflora (Wild) tree also known as Tepezcohuite, belonging to the Fabaceae family, prized for its healing and regenerative properties.

Industrial Production Process

• Preparation of reagents. The main raw material includes Mimosa tenuiflora (also known as Mimosa hostilis) bark and water. Additional solvents may be prepared according to the extraction technique used.
• Harvesting and preparation. Mimosa tenuiflora bark is preferably harvested from mature trees to ensure the maximum concentration of bioactive compounds. The harvested bark is then washed to remove dirt and impurities.
• Drying and grinding. The washed bark is dried at a controlled temperature to preserve nutrients and bioactive compounds. Once dried, the bark is ground into a fine powder.
• Extraction. The Mimosa tenuiflora bark powder is soaked in a suitable solvent, such as water, ethanol, or a mixture of both. The mixture is heated and agitated to enhance the extraction of bioactive compounds.
• Filtration and removal of impurities. The extracted mixture is filtered to remove solid residues and impurities, resulting in a solution rich in bioactive compounds.
• Concentration. The filtered solution is concentrated through vacuum evaporation to remove excess water and increase the concentration of the extract.
• Stabilization. The concentrated extract is stabilized to ensure its stability during transportation and storage, preventing degradation.
• Quality control. The Mimosa tenuiflora bark extract undergoes rigorous quality testing to ensure it meets standards for purity, efficacy, and safety. These tests include chemical analysis, spectroscopy, and microbiological testing.

What it is used for and where

Mimosa Tenuiflora Bark Extract is rich in bioflavonoids, tannins, and essential nutrients that contribute to its effectiveness in promoting skin regeneration and improving its resilience. It is traditionally used to treat burns, wounds, and other skin injuries due to its ability to stimulate the production of new skin cells. This extract is highly valued in cosmetic skin care formulations, such as creams, serums, and balms, where it helps to reduce scarring, increase skin elasticity, 

Medical

Wound Care Products. Used in formulations to treat burns, ulcers, and other skin injuries, due to its effectiveness in promoting skin regeneration.

Cosmetics - INCI Functions

• Skin protectant. It creates a protective barrier on the skin to defend it from harmful substances, irritants, allergens, pathogens that can cause various inflammatory conditions. These products can also improve the natural skin barrier and in most cases more than one is needed to achieve an effective result.
• Soothing. Ingredient with the task of restoring moisture to the skin, helping in the healing process of irritation, inflammation and skin disorders.

CAS   93685-96-2

EC number    297-646-0

Cosmetic Applications

Regenerative Properties. Stimulates skin regeneration, promoting wound healing and cell renewal, useful for reducing scars and skin marks (2).

Anti-inflammatory Effects. Reduces skin inflammation (3) and redness, ideal for treatments of skin conditions such as acne, psoriasis, and eczema.

Antioxidant Protection. Rich in flavonoids and tannins, it provides antioxidant protection that helps fight damage caused by free radicals and prevents premature aging of the skin.

Purifying Effect. Its antimicrobial properties help cleanse and purify the skin, keeping it healthy and free from impurities (4).

Versatile Applications. Used in a variety of skincare products, including creams, lotions, masks, and regenerative balms.

Other Applications

Dietary Supplements. Sometimes included in supplements to leverage its anti-inflammatory and antioxidant benefits.

Hair Care Products. Applied in scalp treatments to help treat seborrheic dermatitis and promote scalp health.

References_____________________________________________________________________

(1) Martínez-Higuera A, Rodríguez-Beas C, Villalobos-Noriega JMA, Arizmendi-Grijalva A, Ochoa-Sánchez C, Larios-Rodríguez E, Martínez-Soto JM, Rodríguez-León E, Ibarra-Zazueta C, Mora-Monroy R, Borbón-Nuñez HA, García-Galaz A, Candia-Plata MDC, López-Soto LF, Iñiguez-Palomares R. Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment. Sci Rep. 2021 May 28;11(1):11312. doi: 10.1038/s41598-021-90763-w. 

Abstract. In this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV-visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. The gels were characterized by UV-Vis, IR, and rheology. Antimicrobial tests were performed using Staphylococcus aureus and Escherichia coli. Burn wound healing was evaluated in a second-degree burn injury on a Wistar rats model for 14 days and additional skin biopsies were examined with histopathological analysis. Gel with commercial silver nanoparticles (Ag NPs) was prepared and employed as a control on the biological assays. Hydrogel system containing silver nanoparticles synthesized with Mimosa tenuiflora (AgMt NPs-G) is a promising therapeutic strategy for burn wound healing, this due to bactericidal and anti-inflammatory effects, which promotes a more effective recovery (in percentage terms) by damaged area.

(2) Zippel J, Deters A, Hensel A. Arabinogalactans from Mimosa tenuiflora (Willd.) Poiret bark as active principles for wound-healing properties: specific enhancement of dermal fibroblast activity and minor influence on HaCaT keratinocytes. J Ethnopharmacol. 2009 Jul 30;124(3):391-6. doi: 10.1016/j.jep.2009.05.034. 

Abstract. Ethnopharmacological relevance: Aqueous extracts from the bark of Mimosa tenuiflora (Willd.) Poirett (Mimosaceae), tradionally known as "tepescohuite", are widely used for wound-healing and burns in middle and South America. No pharmacological data are available on the influence of aqueous extracts and high molecular constituents on human skin cells....Conclusions: A significant in vitro stimulation of dermal fibroblast activity and proliferation by arabinogalactans from Mimosa tenuiflora provides a rational for the traditional use of the bark material for wound healing.

(3) López Villarreal SM, Elizondo Luévano JH, Pérez Hernández RA, Sánchez García E, Verde Star MJ, Castro Ríos R, Garza Tapia M, Rodríguez Luis OE, Chávez Montes A. Preliminary Study of the Antimicrobial, Anticoagulant, Antioxidant, Cytotoxic, and Anti-Inflammatory Activity of Five Selected Plants with Therapeutic Application in Dentistry. Int J Environ Res Public Health. 2022 Jun 28;19(13):7927. doi: 10.3390/ijerph19137927. 

Abstract. The usefulness of traditional plants in Mexico to treat human ailments has been known since ancient times. This work evaluated the antimicrobial, anticoagulant, antioxidant, cytotoxic, and anti-inflammatory potential of ethanolic extracts of Aloe vera, Equisetum arvense, Mimosa tenuiflora, Lippia graveolens, and Syzygium aromaticum. The antimicrobial activity of the extracts was evaluated against Streptococcus mutans and Streptococcus sorbinus; a significant inhibitory effect of the L. graveolens extract on both bacteria was observed at concentration levels of 250 µg/mL and greater. The anticoagulant activity was evaluated in terms of prothrombin time (PT) and activated partial thromboplastin time (APTT), A. vera and M. tenuiflora extracts showed no significant difference (p ˂ 0.05) in PT compared with the control, and for APTT the extracts of A. vera, L. graveolens, and S. aromaticum decreased the APTT significantly (p ˂ 0.05) compared with the control. The antioxidant potential by DPPH assay indicated that the E. arvense extract behaved statistically the same as the control. The cytotoxic activity was evaluated in HGF-1 cells using the fluorometric microculture cytotoxicity assay technique, and none of the extracts was toxic at 125 and 250 µg/mL concentrations. Finally, the anti-inflammatory activity was evaluated using ELISA, where the A. vera extract showed the best anti-inflammatory capacity. Further research on the search for bioactive metabolites and elucidation of action mechanisms of the most promising extracts will be carried out.

(4) Lozoya, X., Navarro, V., Arnason, J. T., & Kourany, E. (1989). Experimental evaluation of mimosa tenuiflora (willd.) poir.(Tepescohuite) I. Screening of the antimicrobial properties of bark extracts. Archivos de investigacion medica, 20(1), 87-93.

Abstract. Mimosa tenuiflora (Willd.) Poir, is a tree from the south areas of Mexico. This bark is popularly used as remedy to treat different skin lesions. The present study demonstrates the in vitro antimicrobial properties of the water and ethanolic extracts prepared with the dried and powdered bark of this plant. A clear inhibition growth effect was observed in all the gram positive and gram negative organisms, yeasts and dermatophytes used.