Compendio degli studi più significativi con riferimento a proprietà, assunzione, effetti.

Ferro AC, de Souza Paglarini C, Rodrigues Pollonio MA, Lopes Cunha R. Glyceryl monostearate-based oleogels as a new fat substitute in meat emulsion. Meat Sci. 2021 Apr;174:108424. doi: 10.1016/j.meatsci.2020.108424.

Abstract. The results showed that monostearate-based oleogel can be a potential fat replacer with higher amount of unsaturated fatty acids to be used in meat products, but retaining the desired characteristics of the traditional products.

Chatchawalsaisin J, Podczeck F, Newton JM. The preparation by extrusion/spheronization and the properties of pellets containing drugs, microcrystalline cellulose and glyceryl monostearate. Eur J Pharm Sci. 2005 Jan;24(1):35-48. doi: 10.1016/j.ejps.2004.09.008

Abstract. The in vitro drug release from the pellets was controlled by the solubility of the drug, the lower the value of the solubility, the longer the mean dissolution time. This was not influenced by the presence of glyceryl monostearate or the method of incorporation of the drug into the formulation.

Cheng J, Dudu OE, Wang D, Li X, Yan T. Influence of interfacial adsorption of glyceryl monostearate and proteins on fat crystallization behavior and stability of whipped-frozen emulsions. Food Chem. 2020 Apr 25;310:125949. doi: 10.1016/j.foodchem.2019.125949.

Abstract. Confocal laser scanning micrographs revealed that big clumps of fat globules were present at air bubble surfaces in anhydrous milk fat whipped-frozen emulsions, while only some individual fat globules were observed in coconut oil systems.

Mengesha AE, Wydra RJ, Hilt JZ, Bummer PM. Binary blend of glyceryl monooleate and glyceryl monostearate for magnetically induced thermo-responsive local drug delivery system. Pharm Res. 2013 Dec;30(12):3214-24. doi: 10.1007/s11095-013-1230-1.

 Abstract. To develop a novel monoglycerides-based thermal-sensitive drug delivery system, specifically for local intracavitary chemotherapy.

Shenoy VS, Rajyaguru TH, Gude RP, Murthy RS. Studies on paclitaxel-loaded glyceryl monostearate nanoparticles. J Microencapsul. 2009 Sep;26(6):471-8. doi: 10.1080/02652040802379902.

Abstract.  Chemosensitivity assay carried out using B16F10 cell lines showed that anti-proliferative activity of Paclitaxel was not hindered due to encapsulation.

Baby AR, Santoro DM, Velasco MV, Dos Reis Serra CH. Emulsified systems based on glyceryl monostearate and potassium cetyl phosphate: scale-up and characterization of physical properties. Int J Pharm. 2008 Sep 1;361(1-2):99-103. doi: 10.1016/j.ijpharm.2008.05.029.

 Abstract. For systems with potassium cetyl phosphate, droplet size increased with the elevation of the emulsifier concentration, suggesting inadequate stability. The scale-up provoked more significant alterations on the rheological profile and droplet size on the anionic systems than the non-ionic.

Yajima T, Itai S, Takeuchi H, Kawashima Y. Determination of optimum processing temperature for transformation of glyceryl monostearate. Chem Pharm Bull (Tokyo). 2002 Nov;50(11):1430-3. doi: 10.1248/cpb.50.1430.

Abstract. Glyceryl monostearate was transformed in the consecutive reaction, and 50 degrees C was the optimum heat-treatment temperature for transforming glyceryl monostearate from the alpha-form to the stable beta-form.