High-intensity sweeteners have been suggested as potential organic contaminants due to their widespread use in food, drugs and sanitary products. As a consequence, they are introduced into the environ ...

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High-intensity sweeteners have been suggested as potential organic contaminants due to their widespread use in food, drugs and sanitary products. As a consequence, they are introduced into the environment by different pathways, affecting aquatic life. In this study, a method based on solid-phase extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS-MS) has been developed and validated for the determination of eight sweeteners (saccharin, cyclamate, aspartame, acesulfame, neohesperidin dihydrochalcone, sucralose, stevioside and glycyrrhizic acid) in river water and wastewater. To get the maximum recoveries in SPE, several commercial sorbents were tested and Oasis HLB gave the best results, with recoveries higher than 41% for all of the compounds in the different matrices. Method limits of detection were in the range of 0.001-0.04μg/L in river water and 0.01-0.5μg/L in influent and effluent wastewater. Method reproducibility between days (n=5) was below 15% for all compounds. The method was applied to the determination of sweeteners in various river waters and wastewaters in Catalonia. Cyclamate, aspartame, neohesperidin dihydrochalcone, acesulfame and sucralose were found in river water, with the two last compounds being present at the highest values (1.62μg/L for acesulfame and 3.57μg/L for sucralose). In influent and effluent wastewater, all of the compounds were found at concentration levels ranging from 0.05 to 155μg/L except for stevioside and neohesperidin dihydrochalcone, which were not detected (1).

Evaluating the environmental impact of artificial sweeteners: a study of their distributions, photodegradation and toxicities (2).

As for human health, Saccharin was (2014) tested in concentrations equal to those found in soft drinks, but, at least in this study, no interference was found on the aryl receptor and on the glucocorticoid receptor (3 ).

References_______________________________________________

(1) Determination of high-intensity sweeteners in river water and wastewater by solid-phase extraction and liquid chromatography-tandem mass spectrometry.

Arbeláez P, Borrull F, Pocurull E, Marcé RM.
J Chromatogr A. 2015 May

(2) Evaluating the environmental impact of artificial sweeteners: a study of their distributions, photodegradation and toxicities.
Sang Z, Jiang Y, Tsoi YK, Leung KS.
Water Res. 2014 Apr

(3) Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells.
Kamenickova A, Pecova M, Bachleda P, Dvorak Z.
Toxicol In Vitro. 2013 Dec.

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