Take only under medical supervision

Estrone is a steroid hormone that belongs to the group of estrogens. It is one of the primary female sex hormones and plays a crucial role in the development and regulation of the female reproductive system. It is present in small amounts in both men and women and is also used in hormone replacement therapy.

Chemical Composition and Structure

• Chemical Formula: C₁₈H₂₂O₂. Its chemical structure includes a steroid nucleus with a ketone group at carbon 3 and a hydroxyl group at carbon 17.

The chemical structure of estrone features a steroid ring system with various functional groups that contribute to its biological activity.

Physical Properties

• Appearance: Pure estrone appears as a white powder or crystals.
• Odor: Generally neutral.
• Solubility: Soluble in organic solvents such as alcohol and chloroform; limited solubility in water.
• pH: Not applicable for pure powder or crystals, but pH of solutions can vary.
• Stability: Chemically stable under recommended storage conditions; should be protected from excessive light and heat.

Production Process

1. Synthesis: Estrone can be chemically synthesized from steroid precursors or extracted from natural sources, such as the urine of pregnant women.
2. Purification: The synthesized estrone is purified to remove contaminants and by-products.
3. Formulation: It can be formulated into various preparations, such as tablets, creams, or gels for therapeutic use.
4. Quality Control: Quality testing is conducted to ensure the purity and concentration of the final product.

Applications

• Medical: Used in hormone replacement therapy to alleviate menopausal symptoms and treat hormonal disorders. It may also be used in the treatment of certain hormone-dependent cancers.
• Cosmetics: Occasionally used in anti-aging cosmetic formulations to improve skin elasticity and hydration and for the treatment of hair regrowth.(1).

Environmental and Safety Considerations

Estrone is generally considered safe for use when following medical guidelines. However, it can cause side effects such as headaches, nausea, and changes in menstrual cycles. It is important to use estrone under medical supervision to avoid adverse effects. The production process should ensure that the ingredient is free from harmful contaminants and produced sustainably.

Come tutti i farmaci può causare effetti collaterali. Consultare sempre il medico.

Molecular Formula  C₁₈H₂₂O₂

Molecular Weight    270.4 g/mol

CAS     53-16-7

UNII    2DI9HA706A    X9XKA379T9

EC Number  200-164-5

Synonyms:

Oestrone

Theelin

References__________________________________________________________________________

(1) Wehner G, Schweikert HU. Estrone sulfate source of estrone and estradiol formation in isolated human hair roots: identification of a pathway linked to hair growth phase and subject to site-, gender-, and age-related modulations. J Clin Endocrinol Metab. 2014 Apr;99(4):1393-9. doi: 10.1210/jc.2013-2607. Epub 2014 Jan 16. PMID: 24432990.

Abstract. Background: The present study investigated the metabolism of estrone sulfate into bioactive estrogens in the human hair root, including the effects of hair growth phase, anatomical site, gender, and age. Methods: Healthy male (n = 18) and female (n = 20) subjects were investigated. Growing (anagen) and resting (telogen) hair roots were collected from selected scalp and body sites. Results: Estrone sulfate metabolism in the hair root yielded substantial levels of estrone and estradiol. Estrogen synthesis exceeded that associated with aromatization of androgens in a previous study. In subjects <50 years old, estrogen synthesis in scalp hair was lower in men than in women. Comparable levels of estrogen formation were observed in 1) male and female axillary and pubic hair and 2) male beard hair. These levels were higher than the estrogen levels detected in the in scalp hair of men <50 years old. With increasing age, estrogen synthesis increased in men and decreased in women. In telogen hair from all body sites, the capacity to form estrone from estrone sulfate remained unaffected, whereas the ability to form estradiol decreased by 62% and 86% in men and women, respectively. Conclusions: Estrogen formation from estrone sulfate in sexually dimorphic hair is linked to the hair growth phase and is subject to gender- and age-related modulations. The magnitude of the in situ estrogen synthesis from estrone sulfate and the selective arrest of estradiol synthesis at the end of the hair cycle suggest that this pathway plays a crucial role in the regulation of human hair growth.

Lephart ED. Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate-A perplexing perspective. J Cosmet Dermatol. 2019 Dec;18(6):1860-1865. doi: 10.1111/jocd.12888. Epub 2019 Feb 15. PMID: 30770632.