Garcinia Mangostana Fruit Juice is an extract of natural origin derived from the mangosteen fruit (Garcinia mangostana), a tropical plant known for its powerful antioxidant properties. Rich in nutrients, vitamins, and bioactive compounds like xanthones, the juice is used in both cosmetic products and supplements to promote skin health and provide protection against oxidative stress. It is particularly valued for its ability to hydrate, regenerate, and protect the skin.

Chemical Composition and Structure

Itis a rich source of xanthones, polyphenols, flavonoids, and vitamin C. Xanthones, such as alpha-mangostin, are among the primary antioxidant compounds present in the juice, which neutralize free radicals and help protect the skin against environmental damage. The combination of these bioactive compounds helps combat oxidative stress while enhancing the skin’s radiance and elasticity.

Physical Properties

The juice has a liquid consistency, ranging from light yellow to brown, with a slightly sweet and tangy flavor. It is water-soluble and easily incorporated into various cosmetic and skincare formulations. With its high nutrient content, the juice acts as a natural moisturizer, improving skin softness and elasticity.

Production Process

The juice is obtained through direct pressing or maceration of the whole Garcinia Mangostana fruit. The extraction process is designed to preserve the nutrient and antioxidant content, ensuring the juice retains its effectiveness in cosmetic and nutritional applications. The juice is then filtered and concentrated for use in products.

• Harvesting the Fruit: Garcinia mangostana fruits are harvested when ripe. It is important to collect the fruits sustainably to ensure the quality of the plant material.

• Cleaning and Preparation: After harvesting, the fruits are cleaned to remove dirt, residues, and impurities. The rind is usually removed to maximize juice extraction from the inner pulp.

• Juice Extraction: The fruit pulp is then subjected to a pressing process to extract the juice. This can be done using mechanical presses or other extraction devices. The extracted juice is collected in containers.

• Filtration: Once obtained, the juice may be filtered to remove any undissolved solids or fibers, resulting in a clearer and more uniform juice.

• Pasteurization: The fruit juice may be pasteurized to eliminate any microorganisms and extend the product's shelf life. This step is important to ensure food safety.

• Quality Control and Packaging: Finally, Garcinia mangostana fruit juice undergoes quality control checks to verify its purity, flavor, and nutritional properties. After analysis, it is packaged in appropriate bottles or containers for distribution and use.

Applications

• Skincare: Used in creams, lotions, and serums for its hydrating and antioxidant properties. The juice helps protect the skin from oxidative stress and enhances the skin’s appearance, making it more radiant and toned.

• Anti-aging Products: Due to its high antioxidant content, Garcinia Mangostana Fruit Juice is ideal for reducing signs of aging such as wrinkles and fine lines while improving skin elasticity.

• Regenerative Products: The juice is often used in regenerative formulations to promote cell renewal and help the skin regain vitality and softness.

INCI Functions:

Antioxidant agent. Ingredient that counteracts oxidative stress and prevents cell damage. Free radicals, pathological inflammatory processes, reactive nitrogen species and reactive oxygen species are responsible for the ageing process and many diseases caused by oxidation.

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

CAS: 90045-25-3     289-884-9

Health and Safety Considerations

Safety in Use
Garcinia Mangostana Fruit Juice is generally considered safe for use in cosmetics and dietary supplements. No significant side effects have been reported when used in appropriate concentrations. Major regulatory authorities, such as the European Union and the FDA, allow its use in skincare products.

Allergic Reactions
Allergic reactions to Garcinia Mangostana Fruit Juice are rare. However, as with any natural ingredient, it is recommended to perform a patch test to check for skin tolerance, especially for sensitive skin.

Toxicity and Carcinogenicity
Its antioxidant compounds are considered beneficial for skin health and protection against environmental damage.

Environmental Considerations
Garcinia Mangostana Fruit Juice is a natural and biodegradable product, sourced from a renewable resource. It is important to ensure that the fruit is harvested sustainably to avoid overexploitation of natural resources.

Regulatory Status
Garcinia Mangostana Fruit Juice is approved for use in cosmetic and food products by major regulatory authorities, including the European Union and the FDA in the United States. It is used in a wide range of skincare products and nutritional supplements.

References__________________________________________________________________________

Shan T, Ma Q, Guo K, Liu J, Li W, Wang F, Wu E. Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med. 2011 Nov;11(8):666-77. doi: 10.2174/156652411797536679. 

Abstract. Despite decades of research, the treatment and management of malignant tumors still remain a formidable challenge for public health. New strategies for cancer treatment are being developed, and one of the most promising treatment strategies involves the application of chemopreventive agents. The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds. Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn., GML), are known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti- tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities. The potential chemopreventive and chemotherapeutic activities of xanthones have been demonstrated in different stages of carcinogenesis (initiation, promotion, and progression) and are known to control cell division and growth, apoptosis, inflammation, and metastasis. Multiple lines of evidence from numerous in vitro and in vivo studies have confirmed that xanthones inhibit proliferation of a wide range of human tumor cell types by modulating various targets and signaling transduction pathways. Here we provide a concise and comprehensive review of preclinical data and assess the observed anticancer effects of xanthones, supporting its remarkable potential as an anticancer agent.

Barua A, Choudhury P, Mandal S, Panda CK, Saha P. Therapeutic potential of xanthones from Swertia chirata in breast cancer cells. Indian J Med Res. 2020 Sep;152(3):285-295. doi: 10.4103/ijmr.IJMR_1153_18.

Abstract. Background & objectives: Medicinal plants like Swertia chirata are rich sources of different xanthones. This study was aimed to assess the cytotoxic potential of four most abundant xanthones present in S. chirata both in vivo and in vitro in Ehrlich ascites carcinoma (EAC), a mouse transplantable breast carcinoma cell line and two human breast carcinoma cell lines (MCF-7 and MDA-MB-231).....Results: Among all the xanthones tested XD showed IC50at the lowest dose, and normal cells were unaffected at this dose. Survivability of mice increased significantly when treated with XD compared to other xanthones and cisplatin. Significantly increased ROS and LPO were found in cancer cells as a result of XD treatment which was unaltered in normal cell line. XD induced DNA damage and apoptosis in cancer cell lines. Interpretation & conclusions: Our experimental data indicate that XD may potentially act as a chemotherapeutic agent by enhancing ROS in breast cancer cells thereby leading to apoptosis.

Feng Z, Lu X, Gan L, Zhang Q, Lin L. Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis. Molecules. 2020 Jan 30;25(3):598. doi: 10.3390/molecules25030598.

Abstract. Inflammation is the body's self-protective response to multiple stimulus, from external harmful substances to internal danger signals released after trauma or cell dysfunction. Many diseases are considered to be related to inflammation, such as cancer, metabolic disorders, aging, and neurodegenerative diseases. Current therapeutic approaches include mainly non-steroidal anti-inflammatory drugs and glucocorticoids, which are generally of limited effectiveness and severe side-effects. Thus, it is urgent to develop novel effective anti-inflammatory therapeutic agents. Xanthones, a unique scaffold with a 9H-Xanthen-9-one core structure, widely exist in natural sources. Till now, over 250 xanthones were isolated and identified in plants from the families Gentianaceae and Hypericaceae. Many xanthones have been disclosed with anti-inflammatory properties on different models, either in vitro or in vivo. Herein, we provide a comprehensive and up-to-date review of xanthones with anti-inflammatory properties, and analyzed their drug likeness, which might be potential therapeutic agents to fight against inflammation-related diseases.

Nauman MC, Johnson JJ. The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones. Pharmacol Res. 2022 Jan;175:106032. doi: 10.1016/j.phrs.2021.106032. 

Panda SS, Chand M, Sakhuja R, Jain SC. Xanthones as potential antioxidants. Curr Med Chem. 2013;20(36):4481-507. doi: 10.2174/09298673113209990144. 

Klein-Júnior LC, Campos A, Niero R, Corrêa R, Vander Heyden Y, Filho VC. Xanthones and Cancer: from Natural Sources to Mechanisms of Action. Chem Biodivers. 2020 Feb;17(2):e1900499. doi: 10.1002/cbdv.201900499.