Garcinia Mangostana Peel Powder is a natural ingredient obtained from the peel of the mangosteen fruit (Garcinia mangostana), renowned for its antioxidant, anti-inflammatory, and antimicrobial properties. Rich in xanthones and other bioactive compounds, the mangosteen peel is used in cosmetic products for its ability to protect the skin from environmental damage, promote cell regeneration, and provide anti-aging benefits. The powder is especially valued for its ability to improve skin appearance and strengthen its natural defenses.

Chemical Composition and Structure

This powder is rich in xanthones such as alpha-mangostin and gamma-mangostin, which are powerful antioxidants with proven anti-inflammatory properties. It also contains polyphenols, flavonoids, and tannins, which contribute to its protective and regenerative properties. These bioactive compounds have a polyphenolic chemical structure that makes them effective in neutralizing free radicals, preventing cellular damage, and promoting younger, more radiant skin.

Physical Properties

It has brown color and a fine, light texture. It is soluble in water and easily incorporated into cosmetic formulations such as creams, lotions, and facial masks. Thanks to its high antioxidant content, the powder offers natural protection against premature aging and oxidative stress, while improving the brightness and elasticity of the skin.

Production Process

The peel of the Garcinia Mangostana fruit is dried and then finely ground into powder. The drying and grinding process preserves bioactive compounds such as xanthones and polyphenols, ensuring that the powder retains its beneficial properties for use in cosmetic products.

1. Harvesting the Peel: The peel of Garcinia mangostana is harvested from ripe fruits. It is important to follow sustainable harvesting practices to ensure the quality and biodiversity of the plant.

2. Drying: After harvesting, the peel is cleaned and subjected to a drying process to remove moisture. This step is crucial for preserving the active properties and facilitating subsequent grinding.

3. Milling: The dried peel is then ground into a fine powder using mills or grinders. This process allows for a uniform consistency and enhances the bioavailability of the active compounds present in the peel.

4. Filtration: The resulting powder may be sifted to remove larger particles and achieve a finer powder, if necessary.

5. Quality Control and Packaging: Finally, Garcinia mangostana peel powder undergoes quality control checks to verify its purity, composition, and compliance with standards. After analysis, it is packaged for distribution and use in dietary supplements and cosmetic products.

Garcinia mangostana peel powder is valued for its antioxidant and nutritional properties, contributing to improved overall health and well-being.

Applications

• Skincare: Garcinia Mangostana Peel Powder is used in skincare products such as masks, creams, and lotions for its antioxidant properties, which protect the skin from oxidative stress and promote cell renewal.

• Anti-aging Products: Due to its ability to fight free radicals, the powder is ideal for anti-aging products, reducing the appearance of wrinkles and fine lines and improving skin texture.

INCI Functions:

Abrasive agent. It contains abrasive particles to remove stains or biofilm that accumulate on the stratum corneum or teeth. Baking soda, kieselguhr, silica and many others have abrasive properties. Peeling or exfoliating products used in dermatology or cosmetic applications contain abrasive agents in the form of synthetic microspheres, however, these microspheres, or abrasive particles may not be biodegradable and create pollution in aquatic ecosystems.

CAS: 90045-25-3     289-884-9

• Soothing Products: The powder is also used in products designed to soothe irritated or inflamed skin, thanks to its anti-inflammatory and regenerative properties.

Health and Safety Considerations

Safety in Use
Garcinia Mangostana Peel Powder is considered safe for use in cosmetic products. It is well tolerated by the skin and poses no significant risks of irritation or sensitization. Major regulatory authorities, such as the European Union and the FDA, approve its use in skincare products.

Allergic Reactions
Allergic reactions to Garcinia Mangostana Peel Powder are rare. However, as with any natural ingredient, it is recommended to perform a patch test before use, especially in individuals with sensitive skin.

Toxicity and Carcinogenicity
Its antioxidant compounds provide protection against oxidative stress, improving overall skin health.

Environmental Considerations
Garcinia Mangostana Peel Powder is a natural, biodegradable product obtained from a renewable resource. The sustainable harvesting of the fruit peel ensures that the extraction process is environmentally friendly and that natural resources are not overexploited.

Regulatory Status
Garcinia Mangostana Peel Powder is approved for use in cosmetic products by major regulatory authorities, including the European Union and the FDA in the United States. It is widely used in skincare formulations, particularly in anti-aging and regenerative products.

References__________________________________________________________________________

Shan T, Ma Q, Guo K, Liu J, Li W, Wang F, Wu E. Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med. 2011 Nov;11(8):666-77. doi: 10.2174/156652411797536679. 

Abstract. Despite decades of research, the treatment and management of malignant tumors still remain a formidable challenge for public health. New strategies for cancer treatment are being developed, and one of the most promising treatment strategies involves the application of chemopreventive agents. The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds. Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn., GML), are known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti- tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities. The potential chemopreventive and chemotherapeutic activities of xanthones have been demonstrated in different stages of carcinogenesis (initiation, promotion, and progression) and are known to control cell division and growth, apoptosis, inflammation, and metastasis. Multiple lines of evidence from numerous in vitro and in vivo studies have confirmed that xanthones inhibit proliferation of a wide range of human tumor cell types by modulating various targets and signaling transduction pathways. Here we provide a concise and comprehensive review of preclinical data and assess the observed anticancer effects of xanthones, supporting its remarkable potential as an anticancer agent.

Barua A, Choudhury P, Mandal S, Panda CK, Saha P. Therapeutic potential of xanthones from Swertia chirata in breast cancer cells. Indian J Med Res. 2020 Sep;152(3):285-295. doi: 10.4103/ijmr.IJMR_1153_18.

Abstract. Background & objectives: Medicinal plants like Swertia chirata are rich sources of different xanthones. This study was aimed to assess the cytotoxic potential of four most abundant xanthones present in S. chirata both in vivo and in vitro in Ehrlich ascites carcinoma (EAC), a mouse transplantable breast carcinoma cell line and two human breast carcinoma cell lines (MCF-7 and MDA-MB-231).....Results: Among all the xanthones tested XD showed IC50at the lowest dose, and normal cells were unaffected at this dose. Survivability of mice increased significantly when treated with XD compared to other xanthones and cisplatin. Significantly increased ROS and LPO were found in cancer cells as a result of XD treatment which was unaltered in normal cell line. XD induced DNA damage and apoptosis in cancer cell lines. Interpretation & conclusions: Our experimental data indicate that XD may potentially act as a chemotherapeutic agent by enhancing ROS in breast cancer cells thereby leading to apoptosis.

Feng Z, Lu X, Gan L, Zhang Q, Lin L. Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis. Molecules. 2020 Jan 30;25(3):598. doi: 10.3390/molecules25030598.

Abstract. Inflammation is the body's self-protective response to multiple stimulus, from external harmful substances to internal danger signals released after trauma or cell dysfunction. Many diseases are considered to be related to inflammation, such as cancer, metabolic disorders, aging, and neurodegenerative diseases. Current therapeutic approaches include mainly non-steroidal anti-inflammatory drugs and glucocorticoids, which are generally of limited effectiveness and severe side-effects. Thus, it is urgent to develop novel effective anti-inflammatory therapeutic agents. Xanthones, a unique scaffold with a 9H-Xanthen-9-one core structure, widely exist in natural sources. Till now, over 250 xanthones were isolated and identified in plants from the families Gentianaceae and Hypericaceae. Many xanthones have been disclosed with anti-inflammatory properties on different models, either in vitro or in vivo. Herein, we provide a comprehensive and up-to-date review of xanthones with anti-inflammatory properties, and analyzed their drug likeness, which might be potential therapeutic agents to fight against inflammation-related diseases.

Nauman MC, Johnson JJ. The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones. Pharmacol Res. 2022 Jan;175:106032. doi: 10.1016/j.phrs.2021.106032. 

Panda SS, Chand M, Sakhuja R, Jain SC. Xanthones as potential antioxidants. Curr Med Chem. 2013;20(36):4481-507. doi: 10.2174/09298673113209990144. 

Klein-Júnior LC, Campos A, Niero R, Corrêa R, Vander Heyden Y, Filho VC. Xanthones and Cancer: from Natural Sources to Mechanisms of Action. Chem Biodivers. 2020 Feb;17(2):e1900499. doi: 10.1002/cbdv.201900499.