Hydrolyzed Garcinia Mangostana Fruit Extract is derived from the mangosteen fruit (Garcinia mangostana) through a hydrolysis process that breaks down complex compounds into simpler, more easily absorbable forms. This extract is rich in antioxidants, including xanthones, polyphenols, and flavonoids, making it a valuable ingredient for cosmetic products, particularly in skincare. Hydrolysis enhances the bioavailability of the compounds, improving their efficacy in moisturizing, regenerating, and protecting the skin from oxidative damage.

Chemical Composition and Structure

The hydrolyzed extract contains a combination of xanthones (such as alpha-mangostin), polyphenols, vitamin C, and other bioactive compounds. The hydrolysis process breaks down molecules into shorter chains, increasing their ability to penetrate the skin and provide antioxidant and regenerative benefits. This enhanced bioavailability allows for more effective protection against free radicals and better support for collagen production.

Physical Properties

Hydrolyzed Garcinia Mangostana Fruit Extract appears as a light liquid or fine powder, soluble in water. It has a brown color and a texture that allows for easy incorporation into creams, serums, and lotions. The hydrolysis process ensures rapid absorption into the skin, providing enhanced moisturizing and antioxidant effects.

Production Process

The hydrolyzed extract is produced through an enzymatic or chemical process that breaks down the components of the fruit into smaller particles. This hydrolysis process optimizes the bioavailability of active compounds like xanthones and polyphenols, improving their efficacy in cosmetic formulations. The extract is then stabilized for use in a wide range of skincare products.

• Harvesting the Fruit: Garcinia mangostana fruits are harvested when ripe. It is essential to collect the fruits sustainably to ensure the quality of the plant material.

• Cleaning and Preparation: After harvesting, the fruits are cleaned to remove dirt, residues, and impurities. The pulp is then separated from the rind and seeds.

• Hydrolysis: The fruit pulp undergoes a hydrolysis process. This can occur using specific enzymes or acids that break down complex molecules into simpler components, such as amino acids and peptides. Hydrolysis enhances the bioavailability of the bioactive compounds present in the extract.

• Filtration: After hydrolysis, the obtained solution is filtered to remove undissolved solids, resulting in a clear liquid extract containing the hydrolyzed active principles.

• Concentration: The hydrolyzed extract may be further concentrated through evaporation or other methods to obtain a product richer in nutrients and with greater stability.

• Quality Control and Packaging: Finally, hydrolyzed Garcinia mangostana fruit extract undergoes quality control checks to verify its purity, efficacy, and compliance with standards. After analysis, it is packaged for distribution and use in cosmetic products and dietary supplements.

Applications

• Skincare: The hydrolyzed extract is used in creams, lotions, and serums for its moisturizing and antioxidant properties. It is particularly suited for enhancing skin radiance and combating the signs of aging.

• Anti-aging Products: With its ability to stimulate collagen production and reduce damage from free radicals, the hydrolyzed extract is ideal for reducing wrinkles and fine lines.

• Regenerative Products: The extract promotes cell renewal and tissue repair, contributing to more elastic and youthful-looking skin.

INCI Functions:

Skin conditioning agent. It is the mainstay of topical skin treatment as it has the function of restoring, increasing or improving skin tolerance to external factors, including melanocyte tolerance. The most important function of the conditioning agent is to prevent skin dehydration, but the subject is rather complex and involves emollients and humectants that can be added in the formulation.

CAS: 90045-25-3     289-884-9

Health and Safety Considerations

Safety in Use
Hydrolyzed Garcinia Mangostana Fruit Extract is considered safe for use in cosmetics. It is well tolerated by the skin and does not cause significant irritation. Major regulatory authorities, such as the European Union and the FDA, approve the use of this ingredient in cosmetic products.

Allergic Reactions
Allergic reactions to Hydrolyzed Garcinia Mangostana Fruit Extract are rare, but as with any natural ingredient, a patch test is recommended before use, especially on sensitive skin.

Toxicity and Carcinogenicity
Its antioxidant compounds are considered safe and beneficial for skin health.

Environmental Considerations
Hydrolyzed Garcinia Mangostana Fruit Extract is obtained from a renewable resource, the mangosteen fruit. The production process is environmentally friendly and sustainable, and the product is biodegradable.

Regulatory Status
Hydrolyzed Garcinia Mangostana Fruit Extract is approved for use in cosmetic products by major regulatory authorities, including the European Union and the FDA in the United States. It is widely used in anti-aging and regenerative formulations.

References__________________________________________________________________________

Shan T, Ma Q, Guo K, Liu J, Li W, Wang F, Wu E. Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med. 2011 Nov;11(8):666-77. doi: 10.2174/156652411797536679. 

Abstract. Despite decades of research, the treatment and management of malignant tumors still remain a formidable challenge for public health. New strategies for cancer treatment are being developed, and one of the most promising treatment strategies involves the application of chemopreventive agents. The search for novel and effective cancer chemopreventive agents has led to the identification of various naturally occurring compounds. Xanthones, from the pericarp, whole fruit, heartwood, and leaf of mangosteen (Garcinia mangostana Linn., GML), are known to possess a wide spectrum of pharmacologic properties, including antioxidant, anti- tumor, anti-allergic, anti-inflammatory, anti-bacterial, anti-fungal, and anti-viral activities. The potential chemopreventive and chemotherapeutic activities of xanthones have been demonstrated in different stages of carcinogenesis (initiation, promotion, and progression) and are known to control cell division and growth, apoptosis, inflammation, and metastasis. Multiple lines of evidence from numerous in vitro and in vivo studies have confirmed that xanthones inhibit proliferation of a wide range of human tumor cell types by modulating various targets and signaling transduction pathways. Here we provide a concise and comprehensive review of preclinical data and assess the observed anticancer effects of xanthones, supporting its remarkable potential as an anticancer agent.

Barua A, Choudhury P, Mandal S, Panda CK, Saha P. Therapeutic potential of xanthones from Swertia chirata in breast cancer cells. Indian J Med Res. 2020 Sep;152(3):285-295. doi: 10.4103/ijmr.IJMR_1153_18.

Abstract. Background & objectives: Medicinal plants like Swertia chirata are rich sources of different xanthones. This study was aimed to assess the cytotoxic potential of four most abundant xanthones present in S. chirata both in vivo and in vitro in Ehrlich ascites carcinoma (EAC), a mouse transplantable breast carcinoma cell line and two human breast carcinoma cell lines (MCF-7 and MDA-MB-231).....Results: Among all the xanthones tested XD showed IC50at the lowest dose, and normal cells were unaffected at this dose. Survivability of mice increased significantly when treated with XD compared to other xanthones and cisplatin. Significantly increased ROS and LPO were found in cancer cells as a result of XD treatment which was unaltered in normal cell line. XD induced DNA damage and apoptosis in cancer cell lines. Interpretation & conclusions: Our experimental data indicate that XD may potentially act as a chemotherapeutic agent by enhancing ROS in breast cancer cells thereby leading to apoptosis.

Feng Z, Lu X, Gan L, Zhang Q, Lin L. Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis. Molecules. 2020 Jan 30;25(3):598. doi: 10.3390/molecules25030598.

Abstract. Inflammation is the body's self-protective response to multiple stimulus, from external harmful substances to internal danger signals released after trauma or cell dysfunction. Many diseases are considered to be related to inflammation, such as cancer, metabolic disorders, aging, and neurodegenerative diseases. Current therapeutic approaches include mainly non-steroidal anti-inflammatory drugs and glucocorticoids, which are generally of limited effectiveness and severe side-effects. Thus, it is urgent to develop novel effective anti-inflammatory therapeutic agents. Xanthones, a unique scaffold with a 9H-Xanthen-9-one core structure, widely exist in natural sources. Till now, over 250 xanthones were isolated and identified in plants from the families Gentianaceae and Hypericaceae. Many xanthones have been disclosed with anti-inflammatory properties on different models, either in vitro or in vivo. Herein, we provide a comprehensive and up-to-date review of xanthones with anti-inflammatory properties, and analyzed their drug likeness, which might be potential therapeutic agents to fight against inflammation-related diseases.

Nauman MC, Johnson JJ. The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones. Pharmacol Res. 2022 Jan;175:106032. doi: 10.1016/j.phrs.2021.106032. 

Panda SS, Chand M, Sakhuja R, Jain SC. Xanthones as potential antioxidants. Curr Med Chem. 2013;20(36):4481-507. doi: 10.2174/09298673113209990144. 

Klein-Júnior LC, Campos A, Niero R, Corrêa R, Vander Heyden Y, Filho VC. Xanthones and Cancer: from Natural Sources to Mechanisms of Action. Chem Biodivers. 2020 Feb;17(2):e1900499. doi: 10.1002/cbdv.201900499.