Camellia Japonica Callus Extracellular Vesicles is an extract containing extracellular vesicles derived from the callus of Camellia japonica, obtained through cell culture. These extracellular vesicles are natural microstructures rich in proteins, lipids, and other bioactive compounds that support skin regeneration and protection. They are particularly valued for their regenerative and antioxidant properties, making them ideal for advanced skincare formulations.

Chemical Composition and Structure

The vesicles consist of a variety of proteins, lipids, amino acids, and micro-RNA, which support cellular communication and promote skin regeneration. Their unique lipid structure allows for easy penetration, facilitating the delivery of active ingredients and promoting skin vitality.

Physical Properties

Camellia Japonica Callus Extracellular Vesicles appear as a clear or slightly opaque liquid, water-soluble, and easily incorporated into serums, creams, and lotions. Their cellular-level penetration makes them ideal for regenerative and anti-aging products, offering a deep and lasting effect.

Production Process

The extract is obtained by culturing Camellia japonica callus under controlled laboratory conditions. The extracellular vesicles are isolated through centrifugation and purification processes that preserve their integrity and bioactivity, making them effective for cosmetic use.

Applications

• Medical: Known for its regenerative and antioxidant properties, with potential applications in treatments for cellular repair and skin protection.

• Cosmetics: Camellia Japonica Callus Extracellular Vesicles are used in anti-aging and regenerative products for their ability to improve skin structure and stimulate cellular renewal. They are ideal for serums, creams, and treatments aimed at enhancing skin elasticity and firmness.

INCI Functions:

Skin conditioning agent -  Humectant. Humectants are hygroscopic substances used to minimise water loss in the skin and to prevent it from drying out by facilitating faster and greater absorption of water into the stratum corneum of the epidermis. The epidermis is the most superficial of the three layers that make up the human skin (epidermis, dermis and hypodermis) and is the layer that maintains hydration in all three layers. In turn, the epidermis is composed of five layers: corneum, the most superficial, lucidum, granulosum, spinosum and basale. Humectants have the ability to retain in the stratum corneum the water they attract from the air and have the function of moisturising the skin. It is better to use them before emollients that are oil-based.

Skin conditioning agent - Emollient. Emollients have the characteristic of enhancing the skin barrier through a source of exogenous lipids that adhere to the skin, improving barrier properties by filling gaps in intercorneocyte clusters to improve hydration while protecting against inflammation. In practice, they have the ability to create a barrier that prevents transepidermal water loss.  Emollients are described as degreasing or refreshing additives that improve the lipid content of the upper layers of the skin by preventing degreasing and drying of the skin. The problem with emollients is that many have a strong lipophilic character and are identified as occlusive ingredients; they are oily and fatty materials that remain on the skin surface and reduce transepidermal water loss. In cosmetics, emollients and moisturisers are often considered synonymous with humectants and occlusives.

Skin protectant. It creates a protective barrier on the skin to defend it from harmful substances, irritants, allergens, pathogens that can cause various inflammatory conditions. These products can also improve the natural skin barrier and in most cases more than one is needed to achieve an effective result.

CAS     223748-13-8

• Industry: In the cosmetic industry, they are valued for their ability to promote cellular regeneration and protection, finding applications in advanced skincare formulations.

Environmental and Safety Considerations
Camellia Japonica Callus Extracellular Vesicles are considered safe for cosmetic use and are biodegradable. Since they are derived from cell cultures, they have a minimal environmental impact and do not require harvesting mature plants, supporting sustainable production.

For further information and studies:

Camellia japonica