Sodium acid carbonate is commonly used as a leavening agent in baked products, but it has some very specific applications including the cases of glutathione synthetase deficiency, a rare congenital de ...

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Sodium acid carbonate is commonly used as a leavening agent in baked products, but it has some very specific applications including the cases of glutathione synthetase deficiency, a rare congenital defect of glutathione metabolism. He demonstrated with effective results (1).

Also used as a bleach in various formulas, including those used in toothpaste (2).

Sodium carbonate and chitosan (3).

This randomized, examiner-blind, crossover clinical study compared the plaque removal efficacy of three experimental toothpastes containing 20%, 35%, and 50% w/w sodium bicarbonate (NaHCO3) with commercial toothpastes containing 67% and 0% w/w NaHCO3 (positive and negative controls, respectively). There was no statistically significant difference in change in mean Quigley-Hein Plaque Index score between toothpastes containing 67% w/w NaHCO3 and 0% w/w NaHCO3 following a single timed brushing. This unexpected observation may be attributed to lower than expected reduction in overall plaque and a possible Hawthorne effect. As study validation was not met, no further conclusions can be made. The study products were generally well tolerated (4).

References_____________________________

(1) Clinical findings and effect of sodium hydrogen carbonate in patients with glutathione synthetase deficiency.
Gündüz M, Ünal Ö, Kavurt S, Türk E, Mungan NÖ.
J Pediatr Endocrinol Metab. 2016 Apr
(2) Bleaching using 30% hydrogen peroxide and sodium hydrogen carbonate.
Ito Y, Momoi Y.
Dent Mater J. 2011;30(2):193-8.
(3) N-Alkylations of chitosan promoted with sodium hydrogen carbonate under aqueous conditions.
Kurita Y, Isogai A.
Int J Biol Macromol. 2012 Apr
(4) Randomized Clinical Dose-Response Study to Evaluate Plaque Removal by Three Experimental Sodium Bicarbonate Toothpastes Using a Single Brushing Model.
Jose A, Parkinson CR, Manger C, Bielfeldt S, Krause C
J Clin Dent. 2018 Dec;29(4):75-80.

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