Risk of depression in pregnant women with low-normal serum Vitamin B12.

Peppard L, Oh KM, Gallo S, Milligan R.
Res Nurs Health. 2019 May 22. doi: 10.1002/nur.21951.

Vitamin B12 Enhances Nerve Repair and Improves Functional Recovery After Traumatic Brain Injury by Inhibiting ER Stress-Induced Neuron Injury.
Wu F, Xu K, Liu L, Zhang K, Xia L, Zhang M, Teng C, Tong H, He Y, Xue Y, Zhang H, Chen D, Hu A.
Front Pharmacol. 2019 Apr 24;10:406. doi: 10.3389/fphar.2019.00406

Neurological disorders in vitamin B12 deficiency.
Pavlov CS, Damulin IV, Shulpekova YO, Andreev EA.
Ter Arkh. 2019 May 16;91(4):122-129. doi: 10.26442/00403660.2019.04.000116.

Association of High Intakes of Vitamins B6 and B12 From Food and Supplements With Risk of Hip Fracture Among Postmenopausal Women in the Nurses' Health Study.
Meyer HE, Willett WC, Fung TT, Holvik K, Feskanich D.
JAMA Netw Open. 2019 May 3;2(5):e193591. doi: 10.1001/jamanetworkopen.2019.3591.

Low Vitamin B12 and Parkinson Disease: Potential Link to Reduced Cholinergic Transmission and Severity of Disease.
McCarter SJ, Teigen LM, McCarter AR, Benarroch EE, St Louis EK, Savica R.
Mayo Clin Proc. 2019 May;94(5):757-762. doi: 10.1016/j.mayocp.2019.01.039.

Baseline serum folate, vitamin B12 and the risk of prostate and breast cancer using data from the Swedish AMORIS cohort.
Essén A, Santaolalla A, Garmo H, Hammar N, Walldius G, Jungner I, Malmström H, Holmberg L, Van Hemelrijck M.
Cancer Causes Control. 2019 Jun;30(6):603-615. doi: 10.1007/s10552-019-01170-6. Epub 2019 Apr 24

Hyperpigmentation due to Vitamin B12 Deficiency.
Araishi K, Nomura Y, Terasaki Y.
Brain Nerve. 2019 Apr;71(4):364-367. doi: 10.11477/mf.1416201277.

Linking vitamin B12 and a trembling disorder.
Green R, Christine CW.
Cell Res. 2019 May;29(5):343-344. doi: 10.1038/s41422-019-0166-3.

Patterns and utility of vitamin B12 and folate testing in patients with isolated thrombocytopenia.
DeLoughery EP, Ravindran A, Ashrani AA, Begna KH, Hook CC, Marshall AL, Pruthi RK, Wolanskyj-Spinner AP, Go RS.
Ann Hematol. 2019 Mar 15. doi: 10.1007/s00277-019-03666-2.

State of the Art Review: Oral and nasal vitamin B12 therapy in the elderly.
Andrès E, Zulfiqar AA, Vogel T.
QJM. 2019 Feb 22. pii: hcz046. doi: 10.1093/qjmed/hcz046

Vitamin B12 as a Treatment for Pain.
Buesing S, Costa M, Schilling JM, Moeller-Bertram T.
Pain Physician. 2019 Jan;22(1):E45-E52. Review.

Vitamin B12 and its binding proteins in milk from cow and buffalo in relation to bioavailability of B12.
Fedosov SN, Nexo E, Heegaard CW.
J Dairy Sci. 2019 Jun;102(6):4891-4905. doi: 10.3168/jds.2018-15016. Epub 2019 Mar 28.

Impact of diet management and composition on vitamin B12 concentration in milk of Holstein cows.
Duplessis M, Pellerin D, Robichaud R, Fadul-Pacheco L, Girard CL.
Animal. 2019 Feb 18:1-9. doi: 10.1017/S1751731119000211.

Comparative Bioavailability of Synthetic B12 and Dietary Vitamin B12 Present in Cow and Buffalo Milk: A Prospective Study in Lactovegetarian Indians.
Mahalle N, Bhide V, Greibe E, Heegaard CW, Nexo E, Fedosov SN, Naik S.
Nutrients. 2019 Feb 1;11(2). pii: E304. doi: 10.3390/nu11020304.

Loss of abcd4 in zebrafish leads to vitamin B12-deficiency anemia.
Choi YM, Kim YI, Choi JH, Bhandari S, Nam IK, Hong K, Kwak S, So HS, Park DS, Kim CH, Choi TY, Choe SK.
Biochem Biophys Res Commun. 2019 May 18. pii: S0006-291X(19)30979-9. doi: 10.1016/j.bbrc.2019.05.099

Vitamin B₁₂ has, among other functions, that of generating red blood cells. The lack of these globules generates anemia. This vitamin contains cobalt which gives it red color and it is also called "cobalamin".

Industrially it appears in the form of a red powder.

Present in the human body, with advanced age, cobalamin thins out and can leave room for oxidative phenomena due to its lack (1).

This vitamin, soluble in water, has a rather complex relationship with the skin (2).

Other important functions are those concerning the digestive system, in particular, the intestine (3), bone health (4) and the nervous system (5).

For further and more complete information: Cyanocobalamin 

Vitamin B12 studies

• Molecular Formula: C₆₃H₈₈CoN₁₄O₁₄P
• Molecular Weight: 1355.388 g/mol
• CAS: 68-19-9
• EC Number: 200-680-0
• PubChem Substance ID 57654727
• Beilstein Registry Number 4122889
• eCl@ss 34058004

Synonyms:

• cyanocobalamin
• Cobavite
• Depinar
• Vibisone
• Cyomin
• BEROCCA PN
• Rubramin PC
• Vi-Twel
• RUBRATOPE-60 KIT
• Vitamine B12
• Cyanocobalamin;Cyanocob(III)alamin
• Cyanocobalamine
• Crystamine
• Anacobin
• Berubigen
• Prestwick_564
• Vitabee 12
• Crysti-12
• Cyanocob(III)alamin
• RUBIVITE
• RUVITE
• Nascobal
• Redisol
• DSSTox_CID_24346
• DSSTox_RID_80159
• DSSTox_GSID_44346
• Vitamin B12 complex
• cyanoject
• Dicopac
• Bedoz
• Primabalt
• Shovite
• Vibal
• alpha-(5,6-Dimethylbenzimidazolyl)cyanocobamide
• Cobinamide,dihydrogenphosphate(ester),inner salt,3'-ester with(5,6-Dimethyl-1-a-d-ribofuranosyl-1H-benzimidazole-kn3),ion(1+)(9ci)
• Neuroforte-R
• Cobolin-M

References______________________________________________________________________

(1) Functional cobalamin (vitamin B12) deficiency: role of advanced age and disorders associated with increased oxidative stress.
Solomon LR.
Eur J Clin Nutr. 2015 Jan 7. doi: 10.1038/ejcn.2014.272. 

(2) A Review of Vitamin B12 in Dermatology.
Brescoll J, Daveluy S.
Am J Clin Dermatol. 2015 Jan 6. 

(3) Vitamin B12 as a modulator of gut microbial ecology.
Degnan PH, Taga ME, Goodman AL.
Cell Metab. 2014 Nov 4;20(5):769-78. doi: 10.1016/j.cmet.2014.10.002.

(4) Vitamin B12 deficiency and bone health.
Clemens TL.
N Engl J Med. 2014 Sep 4;371(10):963-4. doi: 10.1056/NEJMcibr1407247.

(5) Impaired lysosomal cobalamin transport in Alzheimer's disease.
Zhao H, Li H, Ruberu K, Garner B.
J Alzheimers Dis. 2015;43(3):1017-30. doi: 10.3233/JAD-140681.