This study analyzed and studied the influence of polysorbate 60 (Tween 60) to improve the oral bioavailability of morina. The results showed that Tween 60 increased the bioavailability of morina (1).

Novel formulation to deliver genetic material into the rat retina with incorporation of the natural lipid lycopene into niosome formulations based on cationic lipid DOTMA and polysorbate 60 (2).

The aim of the study was to examine the effects of polysorbate 60 and 80 on intestinal lymphatic transport of a poorly water-soluble compound, halofantrine, using a chylomicron flow blocking approach in rats (3).

References_____________________________

(1) Influence of Polysorbate 60 on Formulation Properties and Bioavailability of Morin-Loaded Nanoemulsions with and without Low-Saponification-Degree Polyvinyl Alcohol.
Ikeuchi-Takahashi Y, Kobayashi A, Ishihara C, Matsubara T, Matsubara H, Onishi H.
Biol Pharm Bull. 2018;41(5):754-760. doi: 10.1248/bpb.b17-00964

(2) Retinal gene delivery enhancement by lycopene incorporation into cationic niosomes based on DOTMA and polysorbate 60.
Mashal M, Attia N, Puras G, Martínez-Navarrete G, Fernández E, Pedraz JL.
J Control Release. 2017 May 28;254:55-64. doi: 10.1016/j.jconrel.2017.03.386. Epub 2017 Mar 24.

(3) Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
Lind ML, Jacobsen J, Holm R, Müllertz A.
Eur J Pharm Sci. 2008 Oct 2;35(3):211-8. doi: 10.1016/j.ejps.2008.07.003. Epub 2008 Jul 15.

What is Polysorbate 60

It is an ester of polyoxyethylated sorbitol monoanhydride (i.e., sorbitan).

What it is used for and where

It is non-ionic surfactant  with lesser quantities of polyoxyethylated esters of sorbitol, emulsifier.

Polysorbate 60 is known for its excellent ability to stabilize oil-in-water emulsions, enhancing the texture and even distribution of insoluble ingredients. This emulsifier is particularly useful in formulas containing both an oil phase and a water phase, such as moisturizing creams, lotions, and hair care products. It ensures that products remain homogeneous during use, preventing ingredient separation and improving the feel on the skin. Polysorbate 60 is also used in foods as a texturing agent and to increase shelf life.

Cosmetics - INCI Functions

Surfactant - Emulsifying agent. Emulsions are thermodynamically unstable and are used to soothe or soften the skin and emulsify, so they need a specific, stabilising ingredient. This ingredient forms a film, lowers the surface tension and makes two immiscible liquids miscible. A very important factor affecting the stability of the emulsion is the amount of the emulsifying agent. Emulsifiers have the property of reducing the oil/water or water/oil interfacial tension, improving the stability of the emulsion and also directly influencing the stability, sensory properties and surface tension of sunscreens by modulating the filmometric performance.

Surfactant - Cleansing agent. Cosmetic products used to cleanse the skin utilise the surface-active action that produces a lowering of the surface tension of the stratum corneum, facilitating the removal of dirt and impurities

It is used in:

• Food as an additive
• Cosmetic products, creams, toothpastes

In predisposed subjects it could give allergy (1), but it is not considered dangerous.

Polysorbate 60 studies

Molecular Formula : C₆₄H₁₂₆O₂₆

Molecular Weight : 

CAS : 9005-67-8

Synonyms :

• Tween 60
• E435
• FEMA Number : 2916

References______________________________

(1) Contact urticaria to a corticosteroid cream: polysorbate 60.
Maibach H, Conant M.
Contact Dermatitis. 1977 Dec;3(6):350-1.