Ellagic Acid

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Ellagic Acid

Rating : 9.7

Evaluation	Evaluation	N. Experts
1	6
2	7
3	8
4	9	3
5	10	7

Pros:

Possible anti-cancer (1) Colon protective (1) Anti-inflammatory (1) Prostate protective (1) Possible anti-cancer - Breast (1)



<1 / 1>from Al222

What is Ellagic acid A natural component, a polyphenol. Where is it? In some plants of the Myrtaceae family, in particular from Eucalyptus Hemifolia, Eucalyptus maculata.It has also been isolated from: Avicennia schaueriana Stapf, a Brazilian endemic mangrove, Avicenniaceae family (1) Tilia Tormentosa, Tiliaceae family (2) Theobroma cacao L.,... (Read the full Tiiip)

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"Description" about Ellagic Acid Review Consensus 8
by FRanier (9976 pt)

2019-Mar-05 16:06

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What is Ellagic acid

A natural component, a polyphenol.

Where is it?

In some plants of the Myrtaceae family, in particular from Eucalyptus Hemifolia, Eucalyptus maculata.It has also been isolated from:

Avicennia schaueriana Stapf, a Brazilian endemic mangrove, Avicenniaceae family (1)

Tilia Tormentosa, Tiliaceae family (2)

Theobroma cacao L., family Sterculiaceae (3)

Terminalia bentzoë (L.), Combretaceae family (4)

Clerodendrum viscosum, Lamiaceae family (5)

Pimenta racemosa, Myrtaceae family (6)

Spondias mombin L., family Anacardiaceae (7),

pomegranate, cranberries, nuts, raspberries and also in the propolis of Brazilian bees Melipona subnitida Ducke (jandaíra) (8)

What is it for?

The very recent studies on its properties are numerous and supported by laboratory tests on animals and people.

The general anti-inflammatory properties (9) and details (10) of this acid have been ascertained.

Moreover :

Hepatoprotective activity (11)
Protection of bowel (12) and colon (13)
Protection of the brain and sciatic nerve (14)
Reduction of tumor cell proliferation in breast cancer (15)
Protection for gastritis and ulcer (16)
Protection for prostate cancer (17)
Skin protection against ultraviolet rays (18)

used as a dye

See also : Ellagic Acid, studies

Molecular Formula : C14H6O8

Molecular Weight : 302.194 g/mol

CAS : 476-66-4

Synonyms :

Benzoaric acid
Eleagic acid
2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione
(1)Benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione, 2,3,7,8-tetrahydroxy-
4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone
4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone hydrate
EINECS 207-508-3
PubChem Substance ID: 24894460
Beilstein Registry Number: 47549
MDL number: MFCD00006914

References______________________________

(1) Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf & Leechman and underlying mechanisms.

Pereira Barbosa JA, Nascimento Santana MA, Campos Leite TC, de Oliveira TB, Barreto Mota FV, Gomes Alves Bastos IV, Corrêa AJC, de Amorim ELC, Cardoso Vieira JR, Sarmento Silva TM, Bandeira Delmiro Santana AL, do Nascimento MS, da Silva TG.

Biomed Pharmacother. 2019 Feb 16;112:108582. doi: 10.1016/j.biopha.2019.01.043.

(2) Secondary metabolites of Tilia tomentosa Moench inflorescences collected in Central Italy: chemotaxonomy relevance and phytochemical rationale of traditional use.

Frezza C, De Vita D, Spinaci G, Sarandrea M, Venditti A, Bianco A.

Nat Prod Res. 2019 Jan 12:1-8. doi: 10.1080/14786419.2018.1550487.

(3) Identification and quantification of free and bound phenolic compounds contained in the high-molecular weight melanoidin fractions derived from two different types of cocoa beans by UHPLC-DAD-ESI-HR-MSn.

Oracz J, Nebesny E, Żyżelewicz D.

Food Res Int. 2019 Jan;115:135-149. doi: 10.1016/j.foodres.2018.08.028. Epub 2018 Aug 12.

(4) N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë.

Apel C, Bignon J, Garcia-Alvarez MC, Ciccone S, Clerc P, Grondin I, Girard-Valenciennes E, Smadja J, Lopes P, Frédérich M, Roussi F, Meinnel T, Giglione C, Litaudon M.

Fitoterapia. 2018 Nov;131:91-95. doi: 10.1016/j.fitote.2018.10.014. Epub 2018 Oct 17.

(5) An ellagic acid isolated from Clerodendrum viscosum leaves ameliorates iron-overload induced hepatotoxicity in Swiss albino mice through inhibition of oxidative stress and the apoptotic pathway.

Shendge AK, Basu T, Panja S, Chaudhuri D, Mandal N.

Biomed Pharmacother. 2018 Oct;106:454-465. doi: 10.1016/j.biopha.2018.06.133. Epub 2018 Jul 11.

(6) Phenolic profile, anti-inflammatory, antinociceptive, anti-ulcerogenic and hepatoprotective activities of Pimenta racemosa leaves.

Moharram FA, Al-Gendy AA, El-Shenawy SM, Ibrahim BM, Zarka MA.

BMC Complement Altern Med. 2018 Jul 5;18(1):208. doi: 10.1186/s12906-018-2260-3

(7) Antiulcer Activity and Potential Mechanism of Action of the Leaves of Spondias mombin L.

Brito SA, de Almeida CLF, de Santana TI, da Silva Oliveira AR, do Nascimento Figueiredo JCB, Souza IT, de Almeida LL, da Silva MV, Borges AS, de Medeiros JW, da Costa Silva Neto J, de Cássia Ribeiro Gonçalves R, Kitagawa RR, Sant'Ana AEG, Rolim LA, de Menezes IRA, da Silva TG, Caldas GFR, Wanderley AG.

Oxid Med Cell Longev. 2018 Apr 26;2018:1731459. doi: 10.1155/2018/1731459. eCollection 2018.

(8) Characterisation of phenolic compounds by UPLC-QTOF-MS/MS of geopropolis from the stingless bee Melipona subnitida (jandaíra).

de Souza SA, da Silva TMG, da Silva EMS, Camara CA, Silva TMS.

Phytochem Anal. 2018 Nov;29(6):549-558. doi: 10.1002/pca.2766. Epub 2018 May 17

(9) Protective efficacy of ellagic acid on glycoproteins, hematological parameters, biochemical changes, and electrolytes in myocardial infarcted rats.

Kannan MM, Quine SD, Sangeetha T.
J Biochem Mol Toxicol. 2012 Jul;26(7):270-5. doi: 10.1002/jbt.21418. Epub 2012 Jun 21.

(10) Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats.
Rosillo MA, Sánchez-Hidalgo M, Cárdeno A, Aparicio-Soto M, Sánchez-Fidalgo S, Villegas I, de la Lastra CA.
Pharmacol Res. 2012 Sep;66(3):235-42. doi: 10.1016/j.phrs.2012.05.006. Epub 2012 Jun 4.

(11) Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice.
Girish C, Pradhan SC.
J Pharmacol Pharmacother. 2012 Apr;3(2):149-55. doi: 10.4103/0976-500X.95515.

(12) Protective effect of ellagic acid and pumpkin seed oil against methotrexate-induced small intestine damage in rats.
El-Boghdady NA.
Indian J Biochem Biophys. 2011 Dec;48(6):380-7.

(13) Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats.
Rosillo MA, Sánchez-Hidalgo M, Cárdeno A, Aparicio-Soto M, Sánchez-Fidalgo S, Villegas I, de la Lastra CA.
Pharmacol Res. 2012 Sep;66(3):235-42. doi: 10.1016/j.phrs.2012.05.006. Epub 2012 Jun 4.

(14) Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats.
Uzar E, Alp H, Cevik MU, Fırat U, Evliyaoglu O, Tufek A, Altun Y.
Neurol Sci. 2012 Jun; Epub 2011 Sep 16.

(15) The antioxidant potency of Punica granatum L. Fruit peel reduces cell proliferation and induces apoptosis on breast cancer.
Dikmen M, Ozturk N, Ozturk Y.
J Med Food. 2011 Dec;14(12):1638-46. doi: 10.1089/jmf.2011.0062. Epub 2011 Aug 23.

Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer.
Rocha A, Wang L, Penichet M, Martins-Green M.
Breast Cancer Res Treat. 2012 Dec;136(3):647-58. doi: 10.1007/s10549-012-2264-5. Epub 2012 Oct 12.

(16) Gastroprotective and ulcer-healing mechanisms of ellagic acid in experimental rats.
Beserra AM, Calegari PI, Souza Mdo C, Dos Santos RA, Lima JC, Silva RM, Balogun SO, Martins DT.
J Agric Food Chem. 2011 Jul 13;59(13):6957-65. doi: 10.1021/jf2003267. Epub 2011 Jun 16.

(17) Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis.
Wang L, Ho J, Glackin C, Martins-Green M.
Transl Oncol. 2012 Oct;5(5):344-55. Epub 2012 Oct 1.

Influence of ellagic acid on prostate cancer cell proliferation: a caspase-dependent pathway.
Malik A, Afaq S, Shahid M, Akhtar K, Assiri A.
Asian Pac J Trop Med. 2011 Jul;4(7):550-5. doi: 10.1016/S1995-7645(11)60144-2.

Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis.
Naiki-Ito A, Chewonarin T, Tang M, Pitchakarn P, Kuno T, Ogawa K, Asamoto M, Shirai T, Takahashi S.
Prostate. 2014 Oct 4. doi: 10.1002/pros.22900.

(18) Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes.
Hseu YC, Chou CW, Senthil Kumar KJ, Fu KT, Wang HM, Hsu LS, Kuo YH, Wu CR, Chen SC, Yang HL.
Food Chem Toxicol. 2012 May;50(5):1245-55. doi: 10.1016/j.fct.2012.02.020. Epub 2012 Feb 22.

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"Ellagic Acid, studies" about Ellagic Acid Review Consensus 9
by Kevin-Wooderly (155 pt)

2019-Mar-05 16:05

(Abstracts) Ellagic acid (EA) was inhibiting lung tumorigenesis induced by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice. In the present s ...

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(Abstracts)

Ellagic acid (EA) was inhibiting lung tumorigenesis induced by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice. In the present study, we observed that the inhibition of lung tumorigenesis was independent of the solvent used to purified EA. Pomegranate peels extract containing punicalagin (alpha and beta anomers) (10 g/kg diet) and oligomeric anthocyanins (6 g/kg diet) did not inhibit lung tumorigenesis. Raspberry extract (2x15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2x15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%. The same treatments inhibit TPA-stimulated hydroperoxide (HPx) production by about 30 and 70%. Raspberry ellagitannins and oligomeric procyanidins respectively inhibit TPA stimulated DNA synthesis by 42 and 26%.Our results suggest that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent. The results of this study show that EA and ellagitannins have different antitumorigenic and antipromoting activities (1).

Punica granatum (pomegranate), an edible fruit originating in the Middle East, has been used as a traditional medicine for treatment of pain and inflammatory conditions such as peptic ulcer. The numerous risks associated with nonsteroidal anti-inflammatory drugs (NSAIDs) for treatment of pain and inflammation give rise to using medicinal herbs as alternative therapies. This study aimed to evaluate the anti-inflammatory effect of isolated compounds from the ethyl acetate (EtOAc) fraction of P. granatum by determination of their inhibitory effects on lipopolysaccharide (LPS), stimulated nitric oxide (NO), prostaglandin E2 (PGE-2), interleukin-6 (IL-6) and cyclooxxgenase-2 (COX-2) release from RAW264.7 cells. The results indicate that ellagic acid, gallic acid and punicalagin may be the compounds responsible for the anti-inflammatory potential of P. granatum (2).

References________________________

(1) Antitumorigenic and antipromoting activities of ellagic acid, ellagitannins and oligomeric anthocyanin and procyanidin.
Castonguay A1, Gali H, Perchellet E, Gao X, Boukharta M, Jalbert G, Okuda T, Yoshida T, Hatano T, Perchellet J.

(2) Anti-inflammatory potential of ellagic acid, gallic acid and punicalagin A&B isolated from Punica granatum.

BenSaad LA, Kim KH, Quah CC, Kim WR, Shahimi M.

BMC Complement Altern Med. 2017 Jan 14;17(1):47. doi: 10.1186/s12906-017-1555-0.

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Component type: Natural

Main substances:

Last update: 2019-03-05 15:43:02

Chemical Risk: No chemical risk

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