Compendium of the most significant studies on properties, intake, and effects.

An insight into toxicity and human-health-related adverse consequences of cosmeceuticals - A review.
Bilal M, Iqbal HMN.
Sci Total Environ. 2019 Jun 20;670:555-568. doi: 10.1016/j.scitotenv.2019.03.261. Epub 2019 Mar 20. Review.

Contact Dermatitis to Medications and Skin Products.
Nguyen HL, Yiannias JA.
Clin Rev Allergy Immunol. 2019 Feb;56(1):41-59. doi: 10.1007/s12016-018-8705-0. Review

Effects of Several Cosmetic Preservatives on ROS-Dependent Apoptosis of Rat Neural Progenitor Cells.
Ryu O, Park BK, Bang M, Cho KS, Lee SH, Gonzales ELT, Yang SM, Kim S, Eun PH, Lee JY, Kim KB, Shin CY, Kwon KJ.
Biomol Ther (Seoul). 2018 Nov 1;26(6):608-615. doi: 10.4062/biomolther.2017.221.

Phototoxic assessment of a sunscreen formulation and its excipients: An in vivo and in vitro study.
Hossy BH, da Costa Leitão AA, Dos Santos EP, Matsuda M, Rezende LB, Rurr JSC, Pinto AV, Ramos-E-Silva M, de Pádula M, de Oliveira Miguel NC.
J Photochem Photobiol B. 2017 Aug;173:545-550. doi: 10.1016/j.jphotobiol.2017.06.043.

Preservatives as important etiologic factors of allergic contact dermatitis.
Kręcisz B, Chomiczewska-Skóra D, Kieć-Świerczyńska M.
Med Pr. 2015;66(3):327-32. doi: 10.13075/mp.5893.00176.

Investigation on formaldehyde release from preservatives in cosmetics.
Lv C, Hou J, Xie W, Cheng H.
Int J Cosmet Sci. 2015 Oct;37(5):474-8. doi: 10.1111/ics.12212. Epub 2015 Mar 9

Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials.
Doi T, Takeda A, Asada A, Kajimura K.
Contact Dermatitis. 2012 Nov;67(5):284-92. doi: 10.1111/j.1600-0536.2012.02073.x. Epub 2012 May 7.

Hydrogel allergic contact dermatitis and imidazolidinyl urea/diazolidinyl urea.
Carvalho R, Maio P, Amaro C, Santos R, Cardoso J.
Cutan Ocul Toxicol. 2011 Dec;30(4):331-2. doi: 10.3109/15569527.2011.562270

Imidazolidinyl Urea is a chemical compound.

It is used in:

• cosmetics
• personal care products

Its function in shampoos and liquid soaps is preservative.

It is a widely discussed component as it can produce formaldehyde  and induce contact dermatitis

Imidazolidinyl Urea studies

Molecular Formula: C₁₁H₁₆N₈O₈

Molecular Weight: 388.297 g/mol

UNII: M629807ATL

CAS: 39236-46-9    82852-50-4  1698942-49-2

EC Number: 254-372-6

MDL number MFCD00221482

PubChem Substance ID 329750152

Synonyms:

• N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]
• 1,1'-Methylenebis(3-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea)
• Methanebis(N,N'-(5-ureido-2,4-diketotetrahydroimidazole)-N,N-dimethylol)
• Germall 115
• N,N''-Methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
• Imidazolinidyl urea
• 1,1'-Methylenebis(3-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
• N',N'''-methanediylbis{1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea}
• Urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-
• 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamino]methyl]urea
• Methanebis(N,N'-(5-Ureido-2,4-Diketotetrahydroimidazole)-N,N-Dimethylol
• N,N''-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidin- yl)urea
• N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
• N,N''-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea)
• N,N'-Methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)
• Urea, N,N''-methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-
• Urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidin- yl)-
• 1,1'-methylenebis{3-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea}
• N,N"-Methylenebis[N"-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea]
• N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
• 1-(2,5-diketo-3-methylol-imidazolidin-4-yl)-3-[[(2,5-diketo-3-methylol-imidazolidin-4-yl)carbamoylamino]methyl]urea
• 1-[1-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]- 3-[[[1-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl] carbamoylamino]methyl]urea
• 1-[3-(hydroxymethyl)-2,5-bis(oxidanylidene)imidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-bis(oxidanylidene)imidazolidin-4-yl]carbamoylamino]methyl]urea
• 1-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-3-[[[[[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]amino]-oxomethyl]amino]methyl]urea
• 1-[3-(hydroxymethyl)-2,5-dioxo-imidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxo-imidazolidin-4-yl]carbamoylamino]methyl]urea
• 1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]c
• 3-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1-[({[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoyl}amino)methyl]urea
• Imidurea, Germall 115;''N',N-methylenebis[3-[1-(hydroxymethyl)- 2,5-dioxoimidazolidin-4-yl]urea]
• N-[3-(hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]{[({[3-(hydroxymethyl)-2,5 -dioxo(1,3-diazolidin-4-yl)]amino}carbonylamino)methyl]amino}carboxamide
• N-[3-(hydroxymethyl)-2,5-dioxo(1,3-diazolidin-4-yl)]{[({N-[3-(hydroxymethyl)-2 ,5-dioxo(1,3-diazolidin-4-yl)]carbamoyl}amino)methyl]amino}carboxamide
• Imidurea [NF]