Improvement of Lipids and Reduction of Oxidative Stress With Octacosanol After Taekwondo Training.
Lee SH, Scott SD, Pekas EJ, Lee JG, Park SY.
Int J Sports Physiol Perform. 2019 May 6:1-7. doi: 10.1123/ijspp.2018-0704

Octacosanol and policosanol prevent high-fat diet-induced obesity and metabolic disorders by activating brown adipose tissue and improving liver metabolism.
Sharma R, Matsuzaka T, Kaushik MK, Sugasawa T, Ohno H, Wang Y, Motomura K, Shimura T, Okajima Y, Mizunoe Y, Ma Y, Saber ZM, Iwasaki H, Yatoh S, Suzuki H, Aita Y, Han SI, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Shimano H.
Sci Rep. 2019 Mar 26;9(1):5169. doi: 10.1038/s41598-019-41631-1.

Octacosanol enhances the proliferation and migration of human umbilical vein endothelial cells via activation of the PI3K/Akt and MAPK/Erk pathways.
Liu YW, Zuo PY, Zha XN, Chen XL, Zhang R, He XX, Liu CY.
Lipids. 2015 Mar;50(3):241-51. doi: 10.1007/s11745-015-3991-2. Epub 2015 Feb 1

High-performance thin-layer chromatography for quantification of 1-octacosanol in Antarctic krill (Euphausia superba Dana).
Gao W, Liu D, Su S.
J Chromatogr Sci. 2015 May-Jun;53(5):811-5. doi: 10.1093/chromsci/bmu098. Epub 2014 Aug 21

Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice.
Wang T, Liu Y, Yang N, Ji C, Chan P, Zuo P.
Neural Regen Res. 2012 May 15;7(14):1080-7. doi: 10.3969/j.issn.1673-5374.2012.14.006.

Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice.
de Oliveira AM, Conserva LM, de Souza Ferro JN, de Almeida Brito F, Lyra Lemos RP, Barreto E.
Int J Mol Sci. 2012;13(2):1598-611. doi: 10.3390/ijms13021598. Epub 2012 Feb 2.

Octacosanol or 1-Octacosanol is extracted from the wheat seed and has antioxidant and anti-inflammatory properties (1).

It also has the action of contrasting fatigue (2) and in this study the advantages of the component on human health (3) and the relationship with degenerative diseases such as Parkinson's disease are discussed.

Octacosanol studies

Molecular Formula: C₂₈H₅₈O

Molecular Weight: 410.771 g/mol

UNII: 81I2215OVK

CAS: 557-61-9

EC Number: 209-181-2

PubChem Substance ID 24897978

MDL number MFCD00044770

Synonyms:

• 1-Octacosanol
• Montanyl alcohol
• Octacosyl alcohol
• Cluytyl alcohol
• n-Octacosanol
• Octacosan-1-ol
• 1-Octacosanol, 90+%
• Q-100644
• Octanosol
• Octacosanol,(S)

References____________________________________________

(1) Antinociceptive and Anti-Inflammatory Effects of Octacosanol from the Leaves of Sabicea grisea var. grisea in Mice.
de Oliveira AM, Conserva LM, de Souza Ferro JN, de Almeida Brito F, Lyra Lemos RP, Barreto E.
Int J Mol Sci. 2012;13(2):1598-611. doi: 10.3390/ijms13021598.

(2) Octacosanol supplementation increases running endurance time and improves biochemical parameters after exhaustion in trained rats.
Kim H, Park S, Han DS, Park T.
J Med Food. 2003 Winter;6(4):345-51.

(3) Octacosanol in human health.
Taylor JC, Rapport L, Lockwood GB.
Nutrition. 2003 Feb;19(2):192-5.