Therapeutic Potential of a Combination of Magnesium Hydroxide Nanoparticles and Sericin for Epithelial Corneal Wound Healing.
Nagai N, Iwai Y, Deguchi S, Otake H, Kanai K, Okamoto N, Shimomura Y.
Nanomaterials (Basel). 2019 May 19;9(5). pii: E768. doi: 10.3390/nano9050768.

Preparation and characterization of novel albumin-sericin nanoparticles as siRNA delivery vehicle for laryngeal cancer treatment.
Yalcin E, Kara G, Celik E, Pinarli FA, Saylam G, Sucularli C, Ozturk S, Yilmaz E, Bayir O, Korkmaz MH, Denkbas EB.
Prep Biochem Biotechnol. 2019 May 8:1-12. doi: 10.1080/10826068.2019.1599395

Design and performance of sericin/poly(vinyl alcohol) hydrogel as a drug delivery carrier for potential wound dressing application.
Tao G, Wang Y, Cai R, Chang H, Song K, Zuo H, Zhao P, Xia Q, He H.
Mater Sci Eng C Mater Biol Appl. 2019 Aug;101:341-351. doi: 10.1016/j.msec.2019.03.111

4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways.
Jo YY, Kim DW, Choi JY, Kim SG.
Sci Rep. 2019 Mar 5;9(1):3448. doi: 10.1038/s41598-019-40027-5.

A Novel Approach for Sericin-Conjugated Silver Nanoparticle Synthesis and Their Potential as Microbicide Candidates.
Lv X, Wang H, Su A, Chu Y.
J Microbiol Biotechnol. 2018 Aug 28;28(8):1367-1375. doi: 10.4014/jmb.1802.02054.

Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis.
Qi C, Xu L, Deng Y, Wang G, Wang Z, Wang L.
Biomater Sci. 2018 Nov 1;6(11):2859-2870. doi: 10.1039/c8bm00934a.

A combined approach for the development of novel sutures with antibacterial and regenerative properties: the role of silver and silk sericin functionalization.
Gallo AL, Pollini M, Paladini F.
J Mater Sci Mater Med. 2018 Aug 9;29(8):133. doi: 10.1007/s10856-018-6142-5.

A Novel AgNPs/Sericin/Agar Film with Enhanced Mechanical Property and Antibacterial Capability.
Wang Y, Cai R, Tao G, Wang P, Zuo H, Zhao P, Umar A, He H.
Molecules. 2018 Jul 23;23(7). pii: E1821. doi: 10.3390/molecules23071821

In vitro efficacy of silk sericin microparticles and platelet lysate for intervertebral disk regeneration.
Bari E, Perteghella S, Marrubini G, Sorrenti M, Catenacci L, Tripodo G, Mastrogiacomo M, Mandracchia D, Trapani A, Faragò S, Gaetani P, Torre ML.
Int J Biol Macromol. 2018 Oct 15;118(Pt A):792-799. doi: 10.1016/j.ijbiomac.2018.06.135. Epub 2018 Jun 27.

Sericin nanomicelles with enhanced cellular uptake and pH-triggered release of doxorubicin reverse cancer drug resistance.
Guo W, Deng L, Yu J, Chen Z, Woo Y, Liu H, Li T, Lin T, Chen H, Zhao M, Zhang L, Li G, Hu Y.
Drug Deliv. 2018 Nov;25(1):1103-1116. doi: 10.1080/10717544.2018.1469686.

Sericin is a natural polymer, a silk-derived protein isolated from the cocoons of the silkworm Bombyx mori.

It appears in the form of a white powder.

What it is used for and where

Cosmetics

It is a protein that regulates the hydration and protection of the skin and hair.

Hair conditioning agent. A large number of ingredients with specific purposes can co-exist in a hair shampoo: cleansers, conditioners, thickeners, mattifying agents, sequestering agents, fragrances, preservatives, special additives. However, the indispensable ingredients are the cleansers and conditioners as they are necessary and sufficient for hair cleansing and manageability. The others act as commercial and non-essential auxiliaries such as: appearance, fragrance, colouring, etc. Hair conditioning agents have the task of increasing shine, manageability and volume, and reducing static electricity, especially after treatments such as colouring, ironing, waving, drying and brushing. They are, in practice, dispersing agents that may contain cationic surfactants, thickeners, emollients, polymers. The typology of hair conditioners includes: intensive conditioners, instant conditioners, thickening conditioners, drying conditioners.

Skin conditioning agent - Miscellaneous.  This ingredient has the task of modifying the condition of the skin when it is damaged or dry by reducing its flakiness and restoring its elasticity.

Used in cosmetics and in products for the care and cleaning of the body such as liquid, gel and other soaps.

Medical

It has many applications in medicine.

It helps cell proliferation (1), promotes better cellular attachment (2).

Experimentally, it is used in the cultivation of hybridomas, T lymphocytes, endothelial cells, stromal cells of the human marrow (3).

Sericin studies

CAS    60650-88-6    60650-89-7

References________________________________________________________________________

(1) Martínez-Mora, C.; Mrowiec, A.; García-Vizcaíno, E.M.; Alcaraz, A.; Cenis, J.L.; Nicolás, F.J. Fibroin and sericin from Bombyx mori silk stimulate cell migration through upregulation and phosphorylation of c-Jun. PLoS ONE 2012, 7, e42271

(2) Terada, S.; Nishimura, T.; Sasaki, M.; Yamada, H.; Miki, M. Sericin, a protein derived from silkworms, accelerates the proliferation of several mammalian cell lines including a hybridoma. Cytotechnology 2002, 40, 3–12.

(3) Verdanova, M.; Pytlik, R.; Kalbacova, M.H. Evaluation of Sericin as a Fetal Bovine Serum-Replacing Cryoprotectant during Freezing of Human Mesenchymal Stromal Cells and Human Osteoblast-Like Cells. Biopreserv. Biobank. 2014, 12, 99–105.