Temporal-spatial distribution of synthetic pyrethroids in overlying water and surface sediments in Guangzhou waterways: potential input mechanisms and ecological risk to aquatic systems.
Li WG, Huang DY, Chen D, Wang C, Wei GL.
Environ Sci Pollut Res Int. 2019 Jun;26(17):17261-17276. doi: 10.1007/s11356-019-05013-4.

Fate and transport of furrow-applied granular tefluthrin and seed-coated clothianidin insecticides: Comparison of field-scale observations and model estimates.
Huff Hartz KE, Edwards TM, Lydy MJ.
Ecotoxicology. 2017 Sep;26(7):876-888. doi: 10.1007/s10646-017-1818-z. Epub 2017 May 30.

Effects of the β1 auxiliary subunit on modification of Rat Na(v)1.6 sodium channels expressed in HEK293 cells by the pyrethroid insecticides tefluthrin and deltamethrin.
He B, Soderlund DM.
Toxicol Appl Pharmacol. 2016 Jan 15;291:58-69. doi: 10.1016/j.taap.2015.12.007.

Mg-Prompted Polyfluoroarene C-H Functionalization: Formal Synthesis of Transfluthrin, Fenfluthrin, and Tefluthrin.
Jia X, Wang J, Ding X, Yang J, Li N, Zhao N, Huang Z.
J Org Chem. 2015 Nov 6;80(21):10874-82. doi: 10.1021/acs.joc.5b02022. Epub 2015 Oct 21.

Coexpression with Auxiliary β Subunits Modulates the Action of Tefluthrin on Rat Na(v)1.6 and Na(v)1.3 Sodium Channels.
Tan J, Choi JS, Soderlund DM.
Pestic Biochem Physiol. 2011 Nov 1;101(3):256-264. Epub 2011 Oct 17.

Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin.
McCavera SJ, Soderlund DM.
Neurotoxicology. 2012 Jun;33(3):384-90. doi: 10.1016/j.neuro.2012.03.007.

Differential state-dependent modification of rat Na(v)1.6 sodium channels expressed in human embryonic kidney (HEK293) cells by the pyrethroid insecticides tefluthrin and deltamethrin.
He B, Soderlund DM.
Toxicol Appl Pharmacol. 2011 Dec 15;257(3):377-87. doi: 10.1016/j.taap.2011.09.021

Actions of Tefluthrin on Rat Na(v)1.7 Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes.
Tan J, Soderlund DM.
Pestic Biochem Physiol. 2011 Sep 1;101(1):21-26.

Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin, and deltamethrin on rat Na(v)1.6 sodium channels.
Tan J, Soderlund DM.
Toxicol Appl Pharmacol. 2010 Sep 15;247(3):229-37. doi: 10.1016/j.taap.2010.07.001.

Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons.
Wu SN, Wu YH, Chen BS, Lo YC, Liu YC.
Toxicology. 2009 Apr 5;258(1):70-7.

Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin.
Tan J, Soderlund DM.
Neurotoxicology. 2009 Jan;30(1):81-9. doi: 10.1016/j.neuro.2008.10.008

Tefluthrin is a chemical component, it belongs to the family of pyrethroids, a broad spectrum insecticide.

Pyrethroids alter the properties of the insect sodium channel by interrupting signaling of the nervous system and causing intoxication.

It can also be used against rodents.

Tefluthrin studies

Molecular Formula: C₁₇H₁₄ClF₇O₂

Molecular Weight: 418.736 g/mol

UNII: 2HE8P42H2J 

CAS: 79538-32-2    76437-51-9  93907-48-3

EC Number: 616-699-6

PubChem Substance ID 329755182

MDL number MFCD00274607

Beilstein Registry Number 8398039

Synonyms:

• Force
• Demand
• 2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate
• (2,3,5,6-Tetrafluoro-4-methylphenyl)methyl ester (1-alpha,3-alpha(z))-(+-)-
• (+/-)-cis-4-Methyltetrafluorobenzyl 3-(2-chloro-3,3,3-trifluoro-prop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylate
• Cyclopropanecarboxylic acid, 3-((1Z)-2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluoro-4-methylphenyl)methyl ester, (1R,3R)-rel-
• Cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluoro-4-methylphenyl)methyl ester, (1-alpha,3-alpha(Z))-(+-)-
• (2,3,5,6-tetrafluoro-4-methylphenyl)methyl (1S,3S)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate
• (1r,3r)-rel-3-((1z)-2-Chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid (2,3,5,6-tetrafluoro-4-methylphenyl)methyl ester
• (1S,3S)-2,3,5,6-tetrafluoro-4-methylbenzyl 3-((Z)-2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate
• 2,3,5,6-tetrafluoro-4-methylbenzyl (1S,3S)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylate
• 2,3,5,6-tetrafluoro-4-methylbenzyl cis-3-((Z)-2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropane carboxylate
• 2,3,5,6-Tetrafluoro-4-methylbenzyl-(z)-(1rs,3rs)-3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropanecarboxylate
• 3alpha-[(Z)-2-Chloro-3,3,3-trifluoro-1-propenyl]-2,2-dimethyl-1alpha-cyclopropanecarboxylic acid 2,3,5,6-tetrafluoro-4-methylbenzyl ester
• 4-methyl-2,3,5,6-tetrafluorobenzyl cis-3-((Z)-2-chloro-3,3.3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropane carboxylate
• Cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluoro-4-methylphenyl)methyl ester, (1-alpha-3-alpha(z)-(+-)-
• SCHEMBL2740810
• SCHEMBL4622567
• CHEBI:78106