Compendium of the most significant studies with reference to properties, intake, effects.

Scarano A, Sbarbati A, Amore R, Iorio EL, Ferraro G, Amuso D. A New Treatment for Local Adiposity with Ascorbic Acid and Ascorbyl-Palmitate Solution: Clinical and Histological Study. Aesthetic Plast Surg. 2020 Oct;44(5):1604-1612. doi: 10.1007/s00266-020-01865-1.

Zhai J, Mantaj J, Vllasaliu D. Ascorbyl Palmitate Hydrogel for Local, Intestinal Delivery of Macromolecules. Pharmaceutics. 2018 Oct 15;10(4):188. doi: 10.3390/pharmaceutics10040188.

Zhou M, Li X, Li Y, Yao Q, Ming Y, Li Z, Lu L, Shi S. Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy. Drug Deliv. 2017 Nov;24(1):1230-1242. doi: 10.1080/10717544.2017.1370619.

Smart RC, Huang MT, Han ZT, Kaplan MC, Focella A, Conney AH. Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of ornithine decarboxylase activity, DNA synthesis, and tumor promotion in mouse skin by ascorbic acid and ascorbyl palmitate. Cancer Res. 1987 Dec 15;47(24 Pt 1):6633-8.

Łupina K, Kowalczyk D, Drozłowska E. Polysaccharide/gelatin blend films as carriers of ascorbyl palmitate - A comparative study. Food Chem. 2020 Dec 15;333:127465. doi: 10.1016/j.foodchem.2020.127465.

Inoue Y, Hibino M, Murata I, Kanamoto I. A Nanocarrier Skin-Targeted Drug Delivery System using an Ascorbic Acid Derivative. Pharm Res. 2017 Dec 28;35(1):1. doi: 10.1007/s11095-017-2311-3.

Bamidele OP, Duodu KG, Emmambux MN. Encapsulation and antioxidant activity of ascorbyl palmitate with maize starch during pasting. Carbohydr Polym. 2017 Jun 15;166:202-208. doi: 10.1016/j.carbpol.2017.02.095.

Wagner KH, Feigl P, Elmadfa I. Ascorbyl palmitate and its synergism to tocopherols. Forum Nutr. 2003;56:347-8

Tufiño C, Bernal C, Ottone C, Romero O, Illanes A, Wilson L. Synthesis with Immobilized Lipases and Downstream Processing of Ascorbyl Palmitate. Molecules. 2019 Sep 5;24(18):3227. doi: 10.3390/molecules24183227.

Zariwala MG, Farnaud S, Merchant Z, Somavarapu S, Renshaw D. Ascorbyl palmitate/DSPE-PEG nanocarriers for oral iron delivery: preparation, characterisation and in vitro evaluation. Colloids Surf B Biointerfaces. 2014 Mar 1;115:86-92. doi: 10.1016/j.colsurfb.2013.11.028.

Fratter A, Biagi D, Cicero AFG. Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data. Mar Drugs. 2019 Aug 29;17(9):508. doi: 10.3390/md17090508.

EFSA Panel on Food Additives and Flavourings (FAF), Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Husøy T, Manco M, Mennes W, Moldeus P, Passamonti S, Shah R, Waalkens-Berendsen I, Wölfle D, Wright M, Dusemund B, Mortensen A, Turck D, Barmaz S, Smeraldi C, Tard A, Vianello G, Rincon AM, Gundert-Remy U. Opinion on the re-evaluation of ascorbyl palmitate (E 304i) as a food additive in foods for infants below 16 weeks of age and the follow-up of its re-evaluation as a food additive for uses in foods for all population groups. EFSA J. 2020 Jun 30;18(6):e06153. doi: 10.2903/j.efsa.2020.6153.

Ascorbyl palmitate is an ester formed by L-ascorbic acid, of which it is a lipophilic derivative, and palmitic acid with relative formation of Vitamin C and is fat-soluble in water. 

It appears in the form of a white powder.

It has emulsifying properties with high hydrophilic-lipophilic balance and performs activities as a coemulsifying and antioxidant agent in drugs, vitamins and cosmetics.

It is labeled with the number E304 in the list of food additives with antioxidant function.

Liposoluble, it has all the characteristics of vitamin C, it is able to be stored in the lipid cell membrane until the body is able to use it.

Antioxidant, improves the activity of the cells of the immune system as it gives oxygen to the radicals produced in the oxidation process by inhibiting their formation.

In a search of scientific studies, I found this one study that finds Ascorbyl palmitate dangerous at high concentrations: synthetic food additives such as Ascorbyl palmitate are commonly used as antioxidants in the food industry. In this study, the cytotoxicity and genotoxicity effect of this chemical compound on human umbilical vein endothelial cells was evaluated. The study concluded that since the results indicated that Ascorbyl palmitate has the ability to induce apoptosis in human umbilical vein endothelial cells it would be better to do a thorough analysis on its wide application in the food industry. At high concentration it can be considered as cytogenotoxic agent. (1).

However, EFSA (European Food Safety Authority) considers the component safe and not subject to maximum daily dose restrictions (2) and confirmed the opinion in 2020 (3).

The scientific literature as a whole considers Ascorbyl palmitate an inhibitor of cell proliferation and DNA synthesis in many types of cancer (4) although, despite having a higher stability, its bioavailability and therapeutic effect are low due to its lipophilicity and low release capacity (5).

It is also able to self-assemble into a hydrogel in vitro (6) therefore useful for the administration of drugs aimed at counteracting inflammation.

Cosmetics

Antioxidant agent. Ingredient that counteracts oxidative stress and prevents cell damage. Free radicals, pathological inflammatory processes, reactive nitrogen species and reactive oxygen species are responsible for the ageing process and many diseases caused by oxidation.

Fragrance. It plays a decisive and important role in the formulation of cosmetic products as it provides the possibility of enhancing, masking or adding fragrance to the final product, increasing its marketability.  The consumer always expects to find a pleasant or distinctive scent in a cosmetic product.

Ascorbyl palmitate studies

Appearance	White powder
Boiling Point	512.7±50.0°C at 760 mmHg
Melting Point	115-118°C(lit.)
Flash Point	164.4±23.6°C
Density	1.2±0.1 g/cm3
PSA	113.29000
LogP	6.07
Refraction Index	1.521
Vapor Pressure	0.0±3.0 mmHg at 25°C
Storage	+15°C to +25°C
Safety

• Molecular Formula  C₂₂H₃₈O₇
• Molecular Weight   414.539 g/mol
• Exact Mass   414.261749
• UNII: QN83US2B0N
• CAS: 137-66-6  120398-58-5  162872-43-7  57233-83-7  924964-24-9  1184913-60-7  2095286-71-6  948551-42-6
• EC Number: 205-305-4
• PubChem Substance ID 329749066
• MDL number MFCD00005377 
• Beilstein Registry Number 96552 
• DSSTox Substance ID  DTXSID3041611
• IUPAC  [(2S)-2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] hexadecanoate
• InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1 
• InChl Key      QAQJMLQRFWZOBN-LAUBAEHRSA-N
• SMILES   CCCCCCCCCCCCCCCC(=O)OCC(C1C(=C(C(=O)O1)O)O)O  
• ChEBI  140768
• RXCUI       1088438
• RTECS   CI7671040

Siynonyms: 

• L-Ascorbyl 6-palmitate
• Ascorbyl monopalmitate
• Ascorbyl palmitate [NF]
• 6-O-Palmitoyl-L-ascorbic acid
• L-Ascorbic acid 6-hexadecanoate
• 6-Palmitoyl-L-ascorbic acid6-O-Palmitoyl ascorbate
• Ascorbyl palmitate (NF)
• Ascorbic acid 6-palmitate
• Ascorbyl palmitate (VAN)
• L(+)-Ascorbyl palmitate, specified according to requirements of USP/Ph.Eur.
• 2-((2R)-3,4-dihydroxy-5-oxo(2-2-hydrofuryl))(2S)-2-hydroxyethyl hexadecanoate
• Ascorbic palmitate
• L-Ascorbyl palmitate
• (S)-2-((R)-3,4-Dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl palmitate 

References___________________________________________________________________

(1) Sohrabi Y, Mohammadzadeh-Aghdash H, Baghbani E, Dehghan P, Ezzati Nazhad Dolatabadi J. Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive. Adv Pharm Bull. 2018 Jun;8(2):341-346. doi: 10.15171/apb.2018.039. 

(2) EFSA Journal 2013;11(2):3104

(3) EFSA Panel on Food Additives and Flavourings (FAF), Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Husøy T, Manco M, Mennes W, Moldeus P, Passamonti S, Shah R, Waalkens-Berendsen I, Wölfle D, Wright M, Dusemund B, Mortensen A, Turck D, Barmaz S, Smeraldi C, Tard A, Vianello G, Rincon AM, Gundert-Remy U. Opinion on the re-evaluation of ascorbyl palmitate (E 304i) as a food additive in foods for infants below 16 weeks of age and the follow-up of its re-evaluation as a food additive for uses in foods for all population groups. EFSA J. 2020 Jun 30;18(6):e06153. doi: 10.2903/j.efsa.2020.6153.

(4) Kalaycioglu GD. Preparation of magnetic nanoparticle integrated nanostructured lipid carriers for controlled delivery of ascorbyl palmitate. MethodsX. 2020 Nov 17;7:101147. doi: 10.1016/j.mex.2020.101147. 

(5) Shi S, Yang L, Yao Q, Li X, Ming Y, Zhao Y. Ascorbic Palmitate as a Bifunctional Drug and Nanocarrier of Paclitaxel for Synergistic Anti-Tumor Therapy. J Biomed Nanotechnol. 2018 Sep 1;14(9):1601-1612. doi: 10.1166/jbn.2018.2615. 

(6) Vemula PK, Boilard E, Syed A, Campbell NR, Muluneh M, Weitz DA, Lee DM, Karp JM. On-demand drug delivery from self-assembled nanofibrous gels: a new approach for treatment of proteolytic disease. J Biomed Mater Res A. 2011 May;97(2):103-10. doi: 10.1002/jbm.a.33020.