Spinosad is a substance of natural origin that is obtained from the fermentation of the bacterium Saccharopolyspora spinosa, naturally present in certain soils.

It is used against insect pests in agriculture, greenhouses, gardens.

It is produced by Dow AgroSciences in Michiga, in Harbor Beach, using soy and cotton seeds.

In 1999 Spinosad was awarded the Presidential Green Chemistry Challenge Award which is the White House award given to products that combine chemistry and sustainable production.

In 2001 Spinosad entered the lists of products authorized by Swiss agriculture by the FIBL organization.

In 2002 it was approved by the American USDA as an active ingredient that can be used in organic farming.

In May 2008 the European Commission admitted the use of Spinosad in organic farming.

Spinosad studies

Molecular Formula: C₄₁H₆₅NO₁₀

Molecular Weight: 731.968 g/mol

UNII: OY0L59V61N

CAS: 131929-60-7  168316-95-8

EC Number:

FEMA Number:

Synonyms:

• Spinosyn A
• Spinosyn-A
• Lepicidin A
• (-)-Spinosyn A
• Spinosad factor A
• SCHEMBL465876
• C11054
• CHEMBL501411
• 2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-2-(6-deoxy-2,3,4-tri-O-methyl-?-L-mannopyranosyloxy)-13-(4-dimethylamino-2,3,4,6-tetradeoxy-?-D-erythropyranosyloxy)-9-ethyl-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione
• (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-13-{[(2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1H-as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranoside
• 1H-as-Indaceno(3,2-d)oxacyclododecin-7,15-dione, 2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-2-((6-deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy)- 13-((5-dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-9-ethyl-14-methyl-, (2R-(2R*,3aS*,5aR*,5bS*,9S*,13S*(2R*,5S*,6R*),14R*,16aS*,16bR*))-

Cytotoxic effects of bio-pesticide spinosad on human lung A549 cells.
Zhang Y, Chen H, Fan Y, Yang Y, Gao J, Xu W, Xu Z, Li Z, Tao L.
Chemosphere. 2019 May 6;230:182-189. doi: 10.1016/j.chemosphere.2019.05.042.

Larvicidal activity of spinosad and its impact on oviposition preferences of the West Nile vector Culex pipiens biotype molestus - A comparison with a chitin synthesis inhibitor.
Antonios M, Dimitrios PP, Christos RI, Giovanni B, Christos AG.
Parasitol Int. 2019 Apr 18:101917. doi: 10.1016/j.parint.2019.04.014

Toxicity of the insecticides spinosad and indoxacarb to the non-target aquatic midge Chironomus riparius.
Monteiro HR, Pestana JLT, Novais SC, Soares AMVM, Lemos MFL.
Sci Total Environ. 2019 May 20;666:1283-1291. doi: 10.1016/j.scitotenv.2019.02.303. Epub 2019 Feb 20.

Exposure to spinosad induces histopathological and cytotoxic effects on the salivary complex of the non-target predator Podisus nigrispinus.
Santos-Junior VCD, Martínez LC, Plata-Rueda A, Bozdoğan H, Zanuncio JC, Serrão JE.
Chemosphere. 2019 Jun;225:688-695. doi: 10.1016/j.chemosphere.2019.03.105. Epub 2019 Mar 15.

Genotoxic and mutagenic assessment of spinosad using bioassays with Tradescantia pallida and Drosophila melanogaster.
Mendonça TP, Davi de Aquino J, Junio da Silva W, Mendes DR, Campos CF, Vieira JS, Barbosa NP, Carvalho Naves MP, Olegário de Campos Júnior E, Alves de Rezende AA, Spanó MA, Bonetti AM, Vieira Santos VS, Pereira BB, Resende de Morais C.
Chemosphere. 2019 May;222:503-510. doi: 10.1016/j.chemosphere.2019.01.182. Epub 2019 Jan 31.

Aedes aegypti larvae treated with spinosad produce adults with damaged midgut and reduced fecundity.
Fernandes KM, Tomé HVV, Miranda FR, Gonçalves WG, Pascini TV, Serrão JE, Martins GF.
Chemosphere. 2019 Apr;221:464-470. doi: 10.1016/j.chemosphere.2019.01.068. Epub 2019 Jan 11.

Efficacy of spinosad on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs.
Oliveira PC, Moraes PA, Scott FB, Verocai GG, Correia TR, Fernandes JI.
Vet Parasitol. 2018 Jul 15;258:53-56. doi: 10.1016/j.vetpar.2018.06.006. Epub 2018 Jun 6.

Spinosad.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.

Effect of GF-120 (Spinosad) Aerial Sprays on Colonies of the Stingless Bee Scaptotrigona mexicana (Hymenoptera: Apidae) and the Honey Bee (Hymenoptera: Apidae).
Gómez-Escobar E, Liedo P, Montoya P, Méndez-Villarreal A, Guzmán M, Vandame R, Sánchez D.
J Econ Entomol. 2018 Jun 2. doi: 10.1093/jee/toy152.