Compendium of the most significant studies with reference to properties, intake, effects.

Ramipril and resveratrol co-treatment attenuates RhoA/ROCK pathway-regulated early-stage diabetic nephropathy-associated glomerulosclerosis in streptozotocin-induced diabetic rats.
Peng X, Su H, Liang D, Li J, Ting WJ, Liao SC, Huang CY.
Environ Toxicol. 2019 May 7. doi: 10.1002/tox.22758

Effects of resveratrol on reducing spermatogenic dysfunction caused by high-intensity exercise.
Guo Y, Wang A, Liu X, Li E.
Reprod Biol Endocrinol. 2019 May 6;17(1):42. doi: 10.1186/s12958-019-0486-7.

The Effect of Resveratrol on the Composition and State of Lipids and the Activity of Phospholipase A2 During the Excitation and Regeneration of Somatic Nerves.
Revin VV, Pinyaev SI, Parchaykina MV, Revina ES, Maksimov GV, Kuzmenko TP.
Front Physiol. 2019 Apr 18;10:384. doi: 10.3389/fphys.2019.00384. eCollection 2019.

Resveratrol and Vascular Function.
Li H, Xia N, Hasselwander S, Daiber A.
Int J Mol Sci. 2019 Apr 30;20(9). pii: E2155. doi: 10.3390/ijms20092155. Review.

Resveratrol inhibits apoptosis by increase in the proportion of chondrocytes in the S phase of cell cycle in articular cartilage of ACLT plus Mmx rats.
Wang Y, Bai L.
Saudi J Biol Sci. 2019 May;26(4):839-844. doi: 10.1016/j.sjbs.2017.04.010. Epub 2017 Apr 27.

How efficient is resveratrol as an antioxidant of the Mediterranean Diet, towards alterations during the aging process?
Silva P, Sureda A, Tur JA, Andreoletti P, Cherkaoui-Malki M, Latruffe N.
Free Radic Res. 2019 May 1:1-311. doi: 10.1080/10715762.2019.1614176

Resveratrol increases stem cell function in the treatment of damaged pancreas.
Chen TS, Kuo CH, Day CH, Pan LF, Chen RJ, Chen BC, Padma VV, Lin YM, Huang CY.
J Cell Physiol. 2019 Apr 29. doi: 10.1002/jcp.28646.

Influence of Resveratrol on the Immune Response.
Malaguarnera L.
Nutrients. 2019 Apr 26;11(5). pii: E946. doi: 10.3390/nu11050946. Review.

Effects of Resveratrol on the Mechanisms of Antioxidants and Estrogen in Alzheimer's Disease.
Kong D, Yan Y, He XY, Yang H, Liang B, Wang J, He Y, Ding Y, Yu H.
Biomed Res Int. 2019 Mar 20;2019:8983752. doi: 10.1155/2019/8983752. eCollection 2019

Effects of resveratrol on laminar shear stress-induced mitochondrial biogenesis in human vascular endothelial cells.
Kim JS, Park JY.
J Exerc Nutrition Biochem. 2019 Mar 31;23(1):7-12. doi: 10.20463/jenb.2019.0002.

Antioxidant effect of resveratrol in single red blood cells measured by thermal fluctuation spectroscopy.
Gallardo MJ, Suwalsky M, Ramírez D, Tapia J, Sepulveda B.
Arch Biochem Biophys. 2019 Apr 15;665:30-35. doi: 10.1016/j.abb.2019.02.011. Epub 2019 Feb 20

Resveratrol is a natural component, a polyphenolic compound that occurs naturally mainly in grapes and peanuts. 

What it is used for and where

Some studies of the 1990s had indicated it as a protective agent for coronary diseases (1) and as a potential protective agent in tumors (2) and as a hepatoprotector.

However, while recognizing the role of antioxidant agent, recent studies have questioned all the positive efficacy of this component both in contrasting cardiovascular disorders, and with respect to tumors and longevity (3).

Cosmetics

Human skin is subject to oxidative stress caused by various factors such as a polluted environment, detergents containing harmful chemical compounds, ultraviolet rays, etc. Resveratrol has demonstrated anti-oxidative properties and moderate activity against hyperpigmentation (4). Some cosmetics companies therefore include it in formulas for anti-ageing and skin care products.

"Resveratrol studies"

Molecular Formula: C₁₄H₁₂O₃

Molecular Weight: 228.247 g/mol

CAS: 501-36-0

UNII: Q369O8926Lcas

PubChem Substance ID: 24278055

MDL number: MFCD00133799

• (E)-5-(4-Hydroxystyryl)benzene-1,3-diol
• (E)-resveratrol
• 3,4',5-Stilbenetriol
• Resvida
• 3,4',5-Trihydroxy-trans-stilbene
• trans-resveratrol
• 3,5,4'-Trihydroxy-trans-stilbene
• 5-[(E)-2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol
• 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
• 3,4',5-trihydroxy-stilbene
• trans-3,4',5-trihydroxystilbene
• (E)-5-(p-Hydroxystyryl)resorcinol
• trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene
• 5-[2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol
• 5-((1E)-2-(4-Hydroxyphenyl)ethenyl)-1,3-benzenediol
• trans-3,4′,5-Trihydroxystilbene
• 1,3-Benzenediol, 5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-
• 3,4',5-Trihydroxystilbene
• 3,5,4'-Trihydroxystilbene
• 5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol

References_______________________

(1) Int J Tissue React. 1996;18(2-3):67-71.  Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4',5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats.  Bertelli AA1, Giovannini L, Stradi R, Bertelli A, Tillement JP.

(2) Science. 1997 Jan 10;275(5297):218-20.  Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.  Jang M1, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM.

(3)  Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults FREE
Richard D. Semba, MD, MPH1; Luigi Ferrucci, MD, PhD2; Benedetta Bartali, PhD3; Mireia Urpí-Sarda, PhD4,5; Raul Zamora-Ros, PhD4,5; Kai Sun, MS1; Antonio Cherubini, MD, PhD6; Stefania Bandinelli, MD7; Cristina Andres-Lacueva, PhD4, JAMA Intern Med. 2014;174(7):1077-1084. doi:10.1001/jamainternmed.2014.1582.

(4) Chen J, Liu Y, Zhao Z, Qiu J. Oxidative stress in the skin: Impact and related protection. Int J Cosmet Sci. 2021 Oct;43(5):495-509. doi: 10.1111/ics.12728.