What is Sinaptic acid

(3,5-dimethoxy-4-hydroxycinnamic acid) is a natural component of fruit and plants.

It is commonly found in spices, berries, fruits, vegetables, cereals and oil seeds

What is it for?

It is known in the medical field as an antioxidant, anti-inflammatory, anti-tumor, neuroprotective and antibacterial.

Studies

The literature reveals that sinapic acid is a bioactive phenolic acid and has the potential to attenuate various chemically-induced toxicities (1).

High-fat diet (HFD) induces oxidative stress and microbial dysbiosis, the latter of which plays a role in the development of metabolic syndrome. This study hypothesized that synaptic acid and resveratrol treatment might be a potential strategy to ameliorate the redox state and gut microbiota composition imbalance (2).

In vivo, sinapic acid could delay the progress of mice osteoarthritis models. This study propose that sinapic acid may be applied as a potential therapeutic drug in osteoarthritis treatment (3).

It is thought that Sinapic acid has anticancer effect on prostate cancer cells. However, more detailed studies should be conduct to illuminate molecular mechanism of apoptotic and antimetastatic activity of Sinapic acid (4).

Molecular Formula : C₁₁H₁₂O₅

Molecular Weight : 224.212 g/mol

CAS : 530-59-6  7362-37-0

Synonyms :

• Synapoic acid
• trans-sinapic acid
• Sinapinic acid
• 2-Propenoic acid, 3-(4-hydroxy-3,5-dimethoxyphenyl)-
• 3,5-dimethoxy-4-hydroxycinnamicacid(sinapinicacid)
• 3,5-dimethoxy-4-hydroxycinnamicacid,predominantlytransisomer
• trans-3,5-Dimethoxy-4-hydroxycinnamic acid
• 4-Hydroxy-3,5-dimethoxy-cinnamic acid
• PubChem Substance ID 329757465
• EC Number: 208-487-3
• MDL number: MFCD00004401
• Beilstein Registry Number: 2699118 

References________________________

(1) Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging - Chunye Chen  Oxid Med Cell Longev. 2016

(2) Sinapic acid and resveratrol alleviate oxidative stress with modulation of gut microbiota in high-fat diet-fed rats.  Yang C, Deng Q, Xu J, Wang X, Hu C, Tang H, Huang F.  Food Res Int. 2019 Feb;116:1202-1211. doi: 10.1016/j.foodres.2018.10.003. Epub 2018 Oct 4.

(3) The protective effect of sinapic acid in osteoarthritis: In vitro and in vivo studies.  Li X, Lin J, Ding X, Xuan J, Hu Z, Wu D, Zhu X, Feng Z, Ni W, Wu A.  J Cell Mol Med. 2019 Mar;23(3):1940-1950. doi: 10.1111/jcmm.14096. Epub 2019 Jan 3.

(4) Anticancer mechanism of Sinapic acid in PC-3 and LNCaP human prostate cancer cell lines.  Eroğlu C, Avcı E, Vural H, Kurar E.  Gene. 2018 May 21. pii: S0378-1119(18)30539-0. doi: 10.1016/j.gene.2018.05.049.