Microcrystalline cellulose
Rating : 7
Evaluation | N. Experts | Evaluation | N. Experts |
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1 | 6 | ||
2 | 7 | ||
3 | 8 | ||
4 | 9 | ||
5 | 10 |
Cons:
Avoid excessive amounts (1)9 pts from lu22
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"Microcrystalline Cellulose studies" about Microcrystalline cellulose Review Consensus 10 by A_Partyns (12876 pt) | 2021-Dec-07 19:10 |
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Compendium of the most significant studies with reference to properties, intake, effects.
Thoorens G, Krier F, Leclercq B, Carlin B, Evrard B. Microcrystalline cellulose, a direct compression binder in a quality by design environment--a review. Int J Pharm. 2014 Oct 1;473(1-2):64-72. doi: 10.1016/j.ijpharm.2014.06.055.
Abstract. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes.
Santos JMD, Ignácio EO, Bis-Souza CV, Silva-Barretto ACD. Performance of reduced fat-reduced salt fermented sausage with added microcrystalline cellulose, resistant starch and oat fiber using the simplex design. Meat Sci. 2021 May;175:108433. doi: 10.1016/j.meatsci.2021.108433.
Abstract. The aim of this study was to evaluate fermented sausages with simultaneous reduction of fat (25%) and salt (25% KCl; 75% NaCl) using up to 2% of three different dietary fiber: microcrystalline cellulose (MCC), resistant starch (RS) and oat fiber (OF). Technological and sensory evaluations used the simplex-centroid mixture design.
Butler DC, Presnell SE, Bruner E, Page T, Cuff R, Phillips A. Microcrystalline Cellulose and Crospovidone Identified in Placentas With Vaginal Misoprostol Use. Am J Forensic Med Pathol. 2020 Sep;41(3):176-181. doi: 10.1097/PAF.0000000000000557.
Abstract. Microcrystalline cellulose and/or crospovidone was identified in 0 (0%) of 88 cases with no vaginal administration or low-dose vaginal administration and 29 (66%) of 44 placentas with high-dose vaginal administration. When identified, microcrystalline cellulose and/or crospovidone is most commonly present on the maternal surfaces of the extraplacental membranes.
Żelaziński T. Properties of Biocomposites from Rapeseed Meal, Fruit Pomace and Microcrystalline Cellulose Made by Press Pressing: Mechanical and Physicochemical Characteristics. Materials (Basel). 2021 Feb 13;14(4):890. doi: 10.3390/ma14040890.
Abstract. This paper presents the results of research on biocomposites made of the mixture of post-extraction rapeseed meal, microcrystalline cellulose and various fruit pomace (chokeberry, blackcurrant, apple and raspberry pomace). The biocomposites were made in the process of mechanical thickening by means of a heated mould (die and stamp) which is located between two heating elements installed on a hydraulic press.
Casanova F, Pereira CF, Ribeiro AB, Freixo R, Costa E, E Pintado M, Fernandes JC, Ramos ÓL. Novel Micro- and Nanocellulose-Based Delivery Systems for Liposoluble Compounds. Nanomaterials (Basel). 2021 Oct 1;11(10):2593. doi: 10.3390/nano11102593.
Abstract. In this context, this review describes the fast-growing field of micro- and nanocellulose based delivery systems with a focus on the release of liposoluble bioactive compounds. The state of research on this field is reviewed in this article, which also covers the chemistry, preparation, properties, and applications of micro- and nanocellulose based delivery systems.
Alekseeva OV, Shibaeva VD, Noskov AV, Ivanov VK, Agafonov AV. Enhancing the Thermal Stability of Ionogels: Synthesis and Properties of Triple Ionic Liquid/Halloysite/MCC Ionogels. Molecules. 2021 Oct 14;26(20):6198. doi: 10.3390/molecules26206198.
Abstract. In this study, an ionic liquid (IL), 1-butyl-3-methylimidazolium acetate, was used to prepare ionogels with microcrystalline cellulose (MCC) and halloysite (Hal). SEM, XRD, TG, DSC, FTIR spectroscopy, conductometry and mechanical tests were used to study the morphology, structure, thermal behaviour and electrophysical and mechanical characteristics of synthesised ionogels.
Portier C, Vigh T, Di Pretoro G, Leys J, Klingeleers D, De Beer T, Vervaet C, Vanhoorne V. Continuous twin screw granulation: Impact of microcrystalline cellulose batch-to-batch variability during granulation and drying - A QbD approach. Int J Pharm X. 2021 Mar 19;3:100077. doi: 10.1016/j.ijpx.2021.100077.
Abstract. This study assessed the impact of microcrystalline cellulose (MCC) batch-to-batch variability and process settings in a continuous twin screw wet granulation and semi-continuous drying line.
Klinger J, Daniels R. Assessing a Mass-Based Method for the Preparation of Low-Dosed Paediatric Capsules with Baclofen and Spironolactone. Pharmacy (Basel). 2021 Mar 8;9(1):56. doi: 10.3390/pharmacy9010056.
Abstract. The hard capsules were prepared using three different bulking agents consisting of either mannitol, lactose-monohydrate and microcrystalline cellulose mixed with 0.5% colloidal silica.
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"Descrizione" about Microcrystalline cellulose Review Consensus 9 by lu22 (2319 pt) | 2023-Jun-26 11:43 |
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Microcrystalline Cellulose (MCC) is an important linear carbohydrate polymer that is biodegradable, biocompatible, renewable, and a low-density compound.
The name describes the structure of the molecule:
The synthesis process takes place in different steps:
It commonly occurs as white crystal powder.
What it is used for and where
Microcrystalline cellulose is a term used to designate refined wood pulp and is used as a texturizer, anti-caking agent, fat substitute, emulsifier, extender, and bulking agent in food production. The most common form is used in vitamin supplements or tablets. It’s used in plaque analysis for virus count as an alternative to carboxymethylcellulose.
Food
Ingredient included in the list of European food additives as E460(i), stabiliser, thickener
Cosmetics
Abrasive agent. It contains abrasive particles to remove stains or biofilm that accumulate on the stratum corneum or teeth. Baking soda, kieselguhr, silica and many others have abrasive properties. Peeling or exfoliating products used in dermatology or cosmetic applications contain abrasive agents in the form of synthetic microspheres, however these microspheres or abrasive particles are not biodegradable and create pollution in aquatic ecosystems.
Absorbent. Absorbs substances dispersed or dissolved in aqueous solutions, water/oil, oil/water.
Anticaking agent. This compound facilitates free flow and prevents aggregation or clumping of substances in a formulation by reducing the tendency of certain particles to stick together.
Bulking agent. It regulates the water content, dilutes other solids, can increase the volume of a product for better flow, acts as a buffer against organic acids, helps to keep the pH of the mixture within a certain level.
Emulsion stabilizer. Emulsions are thermodynamically unstable. Emulsion stabilisers improve the formation and stability of single and double emulsions. It should be noted that in the structure-function relationship, molar mass plays an important role.
Light stabilizer. It prevents light from degrading light-sensitive components and slows down degradation reactions that have already begun. The mechanism is, in a way, similar to antioxidants and the effectiveness depends on the.complexity of the formulation and the density of the product.
Opacifying agent. It is useful into formulations that may be translucent or transparent to make them opaque and less permeable to light.
Viscosity control agent. It controls and adapts viscosity to the required level for optimal chemical and physical stability of the product and dosage in gels, suspensions, emulsions, solutions.
Medical
In the pharmaceutical industry, t is inserted into the coating of medicinal tablets with a thickening and stabilizing function.
Studies
Microcrystalline Cellulose studies
Typical optimal characteristics of Microcrystalline Cellulose as a commercial product
Appearance | White crystalline powder |
Odor | Inodor |
Assay | 97.0-102.0% |
Arsenic | 3mg/kg |
pH | 5 - 7.5 (100 g/l, H₂O, 20 °C) |
Solute in water | 0.24% max |
Loss on drying | 7.0% max |
Residue on ignition | 0.2% max |
Heavy metals | 0.0015% max |
Density | 1.5 g/cm3 (20 °C) |
Ignition temperature | 232 °C |
Bulk density | 70 - 400 kg/m3 |
Storage | +2°C to +30°C. |
Safety |
Synonyms:
References________________________________________________________________
(1) Abdi MM, Md Tahir P, Liyana R, Javahershenas R. A Surfactant Directed Microcrystalline Cellulose/Polyaniline Composite with Enhanced Electrochemical Properties. Molecules. 2018 Sep 26;23(10). pii: E2470. doi: 10.3390/molecules23102470.
(2) Trache D, Hussin MH, Hui Chuin CT, Sabar S, Fazita MR, Taiwo OF, Hassan TM, Haafiz MK Microcrystalline cellulose: Isolation, characterization and bio-composites application-A review. Int J Biol Macromol. 2016 Sep
(3) Hussin MH, Pohan NA, Garba ZN, Kassim MJ, Rahim AA, Brosse N, Yemloul M, Fazita MR, Haafiz MK. Physicochemical of microcrystalline cellulose from oil palm fronds as potential methylene blue adsorbents. Int J Biol Macromol. 2016 Jun
(4) Hou W, Ling C, Shi S, Yan Z. Preparation and characterization of microcrystalline cellulose from waste cotton fabrics by using phosphotungstic acid. Int J Biol Macromol. 2018 Nov 13;123:363-368. doi: 10.1016/j.ijbiomac.2018.11.112
(5) Huang X, Xie F, Xiong X. Surface-modified microcrystalline cellulose for reinforcement of chitosan film. Carbohydr Polym. 2018 Dec 1;201:367-373. doi: 10.1016/j.carbpol.2018.08.085.
(6) Wei X, Huang T, Nie J, Yang JH, Qi XD, Zhou ZW, Wang Y. Bio-inspired functionalization of microcrystalline cellulose aerogel with high adsorption performance toward dyes. Carbohydr Polym. 2018 Oct 15;198:546-555. doi: 10.1016/j.carbpol.2018.06.112.
(7) Pichandi S, Rana S, Parveen S, Fangueiro R. A green approach of improving interface and performance of plant fibre composites using microcrystalline cellulose. Carbohydr Polym. 2018 Oct 1;197:137-146. doi: 10.1016/j.carbpol.2018.05.074. Epub 2018 May 26.
(8) Jeon W, Kim YC, Hong M, Rejinold S, Park K, Yoon I, Yoo S, Lee H, Ahn J. Microcrystalline Cellulose for Delivery of Recombinant Protein-Based Antigen against Erysipelas in Mice. Biomed Res Int. 2018 Jun 11;2018:7670505. doi: 10.1155/2018/7670505. eCollection 2018.
(8) Jeon W, Kim YC, Hong M, Rejinold S, Park K, Yoon I, Yoo S, Lee H, Ahn J. Microcrystalline Cellulose for Delivery of Recombinant Protein-Based Antigen against Erysipelas in Mice. Biomed Res Int. 2018 Jun 11;2018:7670505. doi: 10.1155/2018/7670505. eCollection 2018
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Last update:   2022-07-31 11:21:17 | Chemical Risk:   No chemical risk |