Components that help in anti-arthritic action are substances that can contribute to reducing inflammation and pain associated with arthritis. Here are some examples:

• MSM (Methylsulfonylmethane). Can help reduce pain and inflammation (1).
• Boswellia. An herb that can reduce inflammation and joint pain(2).
• Glucosamine and Chondroitin. Supplements that can help rebuild cartilage and reduce joint pain (3).
• Omega-3 Fatty Acids. Found in fatty fish, flaxseeds, and walnuts, they can reduce inflammation.
• Curcumin. The active ingredient in turmeric, known for its anti-inflammatory properties.
• Vitamin D. Important for bone health and can help reduce pain in people with arthritis.
• Gingerols. Found in ginger, have anti-inflammatory effects.
• Vitamin C. Helps in collagen production and can reduce inflammation.
• Magnesium. Important for bone health and can help relax muscles.
• Regular Physical Exercise. Helps maintain joint flexibility and reduce pain.

Components that can contribute to or exacerbate arthritis include various factors that can increase inflammation and joint pain. Here are some examples:

• High Saturated and Trans Fats Foods. Found in fried foods and packaged snacks, can increase inflammation.
• Refined Sugars. Found in sweets and sugary drinks, can worsen inflammation.

• Alcohol. Excessive consumption can increase inflammation and worsen arthritis symptoms.
• Gluten. For people with gluten sensitivity, it can aggravate inflammation.
• High Glycemic Foods. Like white bread and white rice, can increase inflammation.
• Omega-6 Fatty Acids. Found in many vegetable oils, can promote inflammation if consumed in excess.
• Lack of Physical Exercise. Sedentariness can worsen joint stiffness and pain.
• Cigarette Smoking. Can increase inflammation and worsen arthritis symptoms.
• Stress. Chronic stress can negatively affect inflammation and pain.
• Lack of Sleep. Inadequate sleep can increase inflammation and pain.

The reports  provided on Tiiips website are for informational purposes only and should not replace medical advice. Always consult a healthcare professional before making health-related decisions.

References_____________________________________________________________________

(1) Kim, L. S., Axelrod, L. J., Howard, P., Buratovich, N., & Waters, R. F. (2006). Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage, 14(3), 286-294.

Abstract. Objective. Osteoarthritis (OA) is the most common form of arthritis and the second most common cause of long-term disability among middle-aged and older adults in the United States. Methylsulfonylmethane (MSM) is a popular dietary supplement used as a single agent and in combination with other nutrients, and purported to be beneficial for arthritis. However, there is paucity of evidence to support the use of MSM....Conclusion. MSM (3 g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events. The benefits and safety of MSM in managing OA and long-term use cannot be confirmed from this pilot trial, but its potential clinical application is examined. Underlying mechanisms of action and need for further investigation of MSM are discussed.

(2) Mbiantcha M, Almas J, Atsamo AD, Ateufack G, Shabana SU, Bomba Tatsinkou DF, Yousseu Nana W, Nida D. Anti-inflammatory and anti-arthritic effects of methanol extract of the stem bark of Boswellia dalzielii Hutch (Burseraceae) in rats. Inflammopharmacology. 2018 Dec;26(6):1383-1398. doi: 10.1007/s10787-018-0505-x. 

Abstract. Boswellia dalzielii is a tall tree (more than 13 m high) that produces aromatic white flowers. This plant is commonly used in indigenous medicine across Africa against diarrhea, malaria, vomiting, inflammation and arthritis. The present study focuses on the anti-inflammatory and anti-arthritis potential of methanol extract of Boswellia dalzielii (BDME). Anti-inflammatory activity was evaluated in inflammatory models induced by carrageenan, arachidonic acid, histamine, serotonin, prostaglandin and bradykinin. Anti-arthritis activity was measured using complete Freund's adjuvant model. Intracellular and extracellular ROS production and proliferation of T-cells were evaluated using chemiluminescence and liquid scintillation counter techniques, respectively. TNF-α and IL-1β production were assessed using ELISA and MTT assay performed for cytotoxicity. BDME revealed a significant anti-inflammatory effect by preventing the development of edema caused by carrageenan, arachidonic acid, histamine, serotonin, prostaglandin and bradykinin. For anti-arthritic properties of BDME, the results showed a significant reduction of the joint diameter and a decrease in pain in the treated animals. The extract also showed a noticeable systemic effect, maintaining the values of the evaluated parameters close to normal in treated rats with an inhibition of joint destruction as shown in histopathological analysis. Furthermore, BDME exhibited significant inhibition of extracellular and intracellular ROS production. Still, the extract displayed significant inhibitory activity on T-cell proliferation as well as a reduced production of TNF-α and IL-1β. Boswellia dalzielii could be considered as a promising tract in the prevention and/or management of inflammatory diseases.

(3) Simental-Mendía M, Sánchez-García A, Vilchez-Cavazos F, Acosta-Olivo CA, Peña-Martínez VM, Simental-Mendía LE. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. Rheumatol Int. 2018 Aug;38(8):1413-1428. doi: 10.1007/s00296-018-4077-2. 

Abstract. Although glucosamine and chondroitin sulfate have showed beneficial effects on joint tissues in osteoarthritis (OA), their therapeutic use in the clinical setting is still debatable. Hence, a systematic review and meta-analysis of randomized placebo-controlled trials was conducted to investigate the efficacy of glucosamine and chondroitin sulfate on knee OA symptoms. Medline, SCOPUS, Web of Science, and Google Scholar databases were searched for randomized placebo-controlled trials evaluating the effect of orally administered glucosamine and/or chondroitin sulfate on OA symptoms using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and/or the Visual Analog Scale (VAS). Meta-analysis was conducted using a random-effects model and generic inverse-variance method. Heterogeneity was tested using the I2 statistic index. Treatments with glucosamine and chondroitin were found to significantly reduce pain in VAS [weighted mean difference (WMD) - 7.41 mm, 95% CI - 14.31, - 0.51, p = 0.04 and WMD - 8.35 mm, 95% CI - 11.84, - 4.85, p < 0.00001, respectively]. Their combination did not show this behavior (WMD - 0.28 mm, 95% CI - 8.87, 8.32, p = 0.95). None of the glucosamine, chondroitin or their combination had a significant positive effect on the total WOMAC index and its subscores. Oral supplementation with glucosamine or chondroitin sulfate reduces pain in knee OA. However, there is no additional effect using both therapeutic agents in combination for the management of symptomatic knee OA.